A comparative research on social styles and social contact and interaction behaviors in Celebes crested macaques (Macaca nigra) and Lion tailed macaques (Macaca silenus). by Muhammad Ashraf Mohd Salleh.

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Trajectories of interferon-gamma release assay results over two years in independent cohorts from China, South Africa, Tanzania, and the United States by Chen, C, Xue, H, Horsburgh, CR, Amour, M, Hatherill, M, Tameris, M, von Reyn, CF, Rees, C, Shen, Y, McShane, H, García-Basteiro, AL, Liu, D, Wang, Y, Nathavitharana, RR, Graviss, EA, Shao, Y, Liu, Q, Lu, W, Zhu, L, Martinez, L

“…The annual risk of IGRA reversion was assessed after an IGRA conversion and among those with baseline positivity.…”

Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia by Setiabudiawan, TP, Apriani, L, Verrall, AJ, Utami, F, Schneider, M, Indrati, AR, Halim, PP, Kaplonek, P, Malca, H, Lee, JS, Moorlag, SJCFM, de Bree, LCJ, Mourits, VP, Joosten, LAB, Netea, MG, Alisjahbana, B, McNamara, RP, Alter, G, van Laarhoven, A, Ussher, JE, Sharples, K, Koeken, VACM, Hill, PC, van Crevel, R

“…In heavily exposed Indonesian tuberculosis household contacts (n = 1347), a persistently IGRA negative status was associated with presence of a BCG scar, and - especially among those with a BCG scar - with altered innate immune cells dynamics, higher heterologous (Escherichia coli-induced) proinflammatory cytokine production, and higher inflammatory proteins in the IGRA mitogen tube. …”

Structural and molecular characterization of ligands activating the orphan nuclear receptor Nurr1 (NR4A2) by Ng, Xin Yi

“…This study focuses on Nurr1, an orphan nuclear receptor, due to its essential role in the survival and maintenance of dopaminergic neurons in the substantia nigra of the brain. These dopaminergic neurons are usually lost in PD patients, leading to impaired motor functions. …”
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Friend request accepted: fundamental features of social environments determine social affiliation decisions by Garud, S

“…Next, in a 7T fMRI study (n=24), I found that the subcortical dorsal raphe nucleus represented density-related effects and the substantia nigra (SN) represented friendliness-related effects. …”

From mechanisms to future therapy: a synopsis of isolated REM sleep behavior disorder as early synuclein-related disease by Stefani, A, Antelmi, E, Arnaldi, D, Arnulf, I, During, E, Högl, B, Hu, MMT, Iranzo, A, Luke, R, Peever, J, Postuma, RB, Videnovic, A, Gan-Or, Z

“…RBD pathophysiology is not fully clarified yet, but clinical and basic science suggest that ɑ-syn pathology begins in the lower brainstem where REM atonia circuits are located, including the sublaterodorsal tegmental/subcoeruleus nucleus and the ventral medulla, then propagates rostrally to brain regions such as the substantia nigra, limbic system, cortex. Genetically, there is only a partial overlap between RBD, PD and DLB, and individuals with iRBD may represent a specific subpopulation. …”

Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease by Dehestani, Mohammad, Kozareva, Velina, Blauwendraat, Cornelis, Fraenkel, Ernest, Gasser, Thomas, Bansal, Vikas

“…In the second dataset obtained from the substantia nigra (SN), OPCs displayed an association with UPDRS-III. …”
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An implantable piezoelectric ultrasound stimulator (ImPULS) for deep brain activation by Hou, Jason F, Nayeem, Md Osman Goni, Caplan, Kian A, Ruesch, Evan A, Caban-Murillo, Albit, Criado-Hidalgo, Ernesto, Ornellas, Sarah B, Williams, Brandon, Pearce, Ayeilla A, Dagdeviren, Huseyin E, Surets, Michelle, White, John A, Shapiro, Mikhail G, Wang, Fan, Ramirez, Steve, Dagdeviren, Canan

“…We demonstrated that ImPULS can i) excite neurons in a mouse hippocampal slice ex vivo, ii) activate cells in the hippocampus of an anesthetized mouse to induce expression of activity-dependent gene c-Fos, and iii) stimulate dopaminergic neurons in the substantia nigra pars compacta to elicit time-locked modulation of nigrostriatal dopamine release. …”
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Clinical and neuroimaging markers of prodromal neurodegeneration in rapid eye movement sleep behaviour disorder by Barber, TR

“…Neuromelaninsensitive and susceptibility weighted MRI of the substantia nigra revealed signal changes in RBD patients consistent with early neurodegeneration. …”

Vitamin B12 ameliorates the pathological phenotypes of multiple Parkinson’s disease models by alleviating oxidative stress by Wu, Yue, Zhao, Zhongting, Yang, Naidi, Xin, Chenqi, Li, Zheng, Xu, Jiajia, Ma, Bo, Lim, Kah-Leong, Li, Lin, Wu, Qiong, Yu, Changmin, Zhang, Chengwu

“…Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by progressive loss of dopaminergic neurons in the substantia nigra of the midbrain. The etiology of PD has yet to be elucidated, and the disease remains incurable. …”
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From 2D to 3D: development of monolayer dopaminergic neuronal and midbrain organoid cultures for Parkinson's disease modeling and regenerative therapy by Yeap, Yee Jie, Tng, Teddy J. W., Lee, Mok Jung, Goh, Micaela, Lim, Kah-Leong

“…Parkinson's Disease (PD) is a prevalent neurodegenerative disorder that is characterized pathologically by the loss of A9-specific dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. Despite intensive research, the etiology of PD is currently unresolved, and the disease remains incurable. …”
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Investigating the role of astrocytes in Parkinson's disease pathogenesis in GBA- N370S iPSC-derived neural cultures by Ibarra Aizpurua, N

“…<p>Parkinson’s disease (PD), the second most common neurodegenerative disease, is characterized by the loss of dopaminergic neurons (DAn) in the substantia nigra. However, the research available indicates that other cells found in the midbrain, such as astrocytes, are also involved in the disease pathogenesis, although their role has not been fully elucidated yet. …”