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A facile alternative strategy of upcycling mixed plastic waste into vitrimers
Published 2023“…In this work, we have demonstrated upcycling of mixed plastic waste comprising a mixture of polyester, polyamide, and polyurethane through a reprocessable vitrimer of the depolymerized oligomers. Using poly(ethylene terephthalate) (PET) as a model polymer, we first demonstrated partial controlled depolymerization, using glycerol as a cleaving agent, to obtain branched PET oligomers. …”
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Journal Article -
22
Synthesis and characterization of a novel biodegradable polylactide.
Published 2009“…Three-arm and four-arm star-shaped poly(DL-Lactide) (PLA) oligomers were successfully synthesized using glycerol and pentaerythritol initiator with 4-dimethylaminopyridine (DMAP) organocatalysts by ring-opening polymerization (ROP) in bulk. …”
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Final Year Project (FYP) -
23
Structural study of plant cellulose synthase and atypical profilin3
Published 2020“…A low-resolution model of oligomeric full-length cellulose synthase was also obtained by Cryo-EM. …”
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Thesis-Doctor of Philosophy -
24
Modelling cerebrovascular pathology and the spread of amyloid beta in Alzheimer’s disease
Published 2025“…Experiments have revealed that amyloid beta oligomers induce microvascular mural cells to contract, thereby constricting capillaries and increasing resistance to blood flow. …”
Journal article -
25
The mammalian EMC in membrane protein biogenesis
Published 2016“…<p>The mammalian Endoplasmic Reticulum Membrane protein Complex (mEMC) has previously been implicated in a range of cellular activities, including the biogenesis of oligomeric plasma membrane receptors, endoplasmic reticulum (ER)-mitochondrial phospholipid transfer, and as a host factor modulating viral pathogenicity. …”
Thesis -
26
Unravelling 2-oxoglutarate turnover and substrate oxidation dynamics in 5-methylcytosine-oxidising TET enzymes
Published 2024“…Here, we profile 5-methylcytosine (5mC)-oxidising Ten-Eleven Translocation (TET) enzymes using MS and 1H NMR spectroscopy methods and reveal a high degree of substrate oxidation-independent 2OG turnover under a range of conditions. 2OG decarboxylase activity is substantial (>20% 2OG turned over after 1 h) in the absence of substrate, while, under substrate-saturating conditions, half of total 2OG consumption is uncoupled from substrate oxidation. 2OG kinetics are affected by substrate and non-substrate DNA oligomers, and the sequence-agnostic effects are observed in amoeboflagellate Naegleria gruberi NgTet1 and human TET2. …”
Journal article -
27
Characterization of mechanical properties of polyurea
Published 2023“…The polyurea was successfully synthesized with Isonate-143LP Modified MDI and oligomeric diamine (VERSALINK P1000). The polyureas were allowed to cure until different factors and conditions for up to 5 days. …”
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Final Year Project (FYP) -
28
Recognition of A-U and U-A base pairs in RNA duplexes by modified peptide nucleic acids
Published 2017“…RNA triplex structures play vital roles in regulating various biological processes, and have attracted a Jot of interest in designing TFOs (triplex-fonning oligomers) that could selectively and specifically bind to the nuclei acid duplex. …”
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Thesis -
29
Viroporin activity of the foot-and-mouth disease virus non-structural 2B protein
Published 2015“…Viroporins form transmembrane pores in host cells via oligomerization, thereby destroying cellular homeostasis and inducing cytopathy for virus replication and virion release. …”
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Journal Article -
30
Combatting pathogenic bacteria with synthetic immunotherapeutics from chitosan: antibody recruiting at engineered bacterial surface with peptidoglycan analogs
Published 2024“…In this work, we drew inspiration from synthetic peptidoglycan oligomers and successfully constructed antibody-recruiting peptidoglycan analogs, 2a-d, with excellent safety profiles and high efficiencies in recruiting antibodies across different conditions. …”
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Journal Article -
31
Electronic structure and optical properties of conjugated molecules : SAC-CI study
Published 2013“…Electronic structure and optical properties of some organic conjugated molecules, that is the oligomers for organic-light emitting diodes (OLED), chelating hetero-atomic conjugated ligands, and UVB blocking molecules, have been investigated by the SAC-CI method. …”
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Conference Paper -
32
Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes
Published 2013“…Collectively, the results highlight the promiscuity of our soluble TCR, which could be an advantageous feature when targeting cells infected with a mutation-prone virus, but that binding of the soluble oligomeric TCR relies considerably on the surface density of the presented antigen.…”
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Journal Article -
33
Mechanics and manufacturing of crosslinked cellulose nanocomposites
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Thesis -
34
Evaluating the effect of rapamycin treatment in Alzheimer’s disease and aging using in vivo imaging: the ERAP phase IIa clinical study protocol
Published 2024“…Results from mouse models of Alzheimer’s disease have shown beneficial effects of rapamycin, including preventing or reversing cognitive deficits, reducing amyloid oligomers and tauopathies and normalizing synaptic plasticity and cerebral glucose uptake. …”
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Article -
35
Development of interpenetrating network (IPN) hybrid composite for thin film protection
Published 2013“…In this study, TMPTA, TMPT(EO)A, PEGDA, TPGDA, CN8003, CN104 and Epolam® 5015 were used in the investigation of the formation of simultaneous IPNs with TMPT(EO)A, PEGDA and TPGDA as the most reactive monomers among the seven monomers and oligomers. The effects of composition of individual monomers and temperature were investigated under optimum photoinitiator concentration. …”
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Thesis -
36
Studies on the Chitin Binding Property of Novel Cysteine-Rich Peptides from Alternanthera sessilis
Published 2016“…This indicates that the biosynthesis of altides is through the secretory pathway. (1)H NMR titration experiments showed that the 29-30-amino acid altides bind to chitin oligomers with dissociation constants in the micromolar range. …”
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Journal Article -
37
Synthesis and characterization UV-curable waterborne polyurethane acrylate/Al2O3 nanocomposite coatings derived from Jatropha oil polyol
Published 2022“…The UV-WPUA/Al2O3 coatings were obtained with 75 wt% oligomers, 25 wt% monomer trimethylolpropane triacrylate (TMPTA), and 3 wt% of a commercial photoinitiator (benzhophenol) for UV-curing were used. …”
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Article -
38
Synthesis of heavy cyanide analogs for the design of novel Prussian blue analogs
Published 2023“…The synthesis, characterization, and bonding of the oligomers and their monomer precursors are discussed herein. …”
Thesis -
39
Integrative and comparative analysis of coiled-coil based marine snail egg cases : a model for biomimetic elastomers
Published 2014“…Despite these differences, mixtures of denatured native egg case proteins readily re-folded in citrate–phosphate assembly buffer into α-helix rich, coiled-coil based oligomers, as determined by attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism and MALDI-TOF. …”
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Journal Article -
40
Structural and mechanistic insights into the Rel protein of Mycobacterium tuberculosis
Published 2020“…The MtRel ACT structure was determined as a dimer and the oligomeric state was further confirmed using SAXS. The crucial dimeric interface residues were identified, and the mutants were studied to understand the role of these residues in dimerization. …”
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Thesis-Doctor of Philosophy