Structural analysis and insights into the glycon specificity of the rice GH1 Os7BGlu26 β-D-mannosidase by Robinson, Robert Charles, Tankrathok, Anupong, Iglesias-Fernández, Javier, Luang, Sukanya, Kimura, Atsuo, Rovira, Carme, Hrmova, Maria, Ketudat Cairns, James R.

Get full text
Get full text

Binding of TCR multimers and a TCR-like antibody with distinct fine-specificities is dependent on the surface density of HLA complexes by Low, Jianrong L., Gehring, Adam J., Kranz, David M., Grotenbreg, Gijsbert M., Yau, Yin Hoe, Shochat, Susana Geifman, Bertoletti, Antonio, Naidoo, Anneta, Yeo, Gladys, Ho, Zi Zong

“…In line with this, we report the construction of a soluble tetrameric form of an αβ T cell receptor (TCR) specific for the HBV epitope Env183–191 restricted by HLA-A*02:01, and compare its avidity and fine-specificity with a TCR-like monoclonal antibody generated against the same HLA target. …”
Get full text
Get full text

Development, validation and the effects of culturally specific guided imagery and progressive muscle relaxation audio for patients with functional abdominal bloating by Shen, Vincent Tee Wei

“…Phase 1 involves the development and validation of culturally specific GI and PMR audios. Initially, the audio scripts were drafted according to literature reviews and findings from in-depth interviews with participants diagnosed with bloating based on the Rome IV criteria. …”
Get full text

Investigation of gamma index parameters in patient specific quality assurance (PSQA) for radiotherapy treatment planning technique: retrosective study by Mukhtar, Siti Yuni Sara

“…The patient specific quality assurance (PSQA) is a pre-treatment procedure performed to evaluate the validity of the inversed treatment plans, before the actual radiotherapy (RT) treatment delivery, to ensure the patient’s safety. …”
Get full text

Left Atrial Appendage Occlusion: Current Stroke Prevention Strategies and a Shift Toward Data-Driven, Patient-Specific Approaches by Mendez, Keegan, Kennedy, Darragh G., Wang, Dee Dee, O’Neill, Brian, Roche, Ellen T.

“…Together, we envisage that these techniques will facilitate a pipeline from the imaging of patient anatomy to patient-specific computational and bench-top models that enable customized, data-driven approaches for LAA occlusion that are engineered specifically to meet each patient’s unique needs.…”
Get full text

The rickettsial effector Sca4 has a conserved interaction with host clathrin and a tick cell specific role in infection by Vondrak, Cassandra Joan

“…While many effectors interact with specific host machinery to perform a single distinct function, some effectors are capable of interaction with multiple host proteins to carry out multiple functions. …”
Get full text
Get full text

Homologous Lympho-epithelial Kazal-type inhibitor domains delay blood coagulation by inhibiting factor X and XI with differential specificity by Ramesh, Karthik, Lama, Dilraj, Tan, Kang Wei, Nguyen, Van Sang, Chew, Fook Tim, Verma, Chandra Shekhar, Mok, Yu Keung

Get full text

Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore by Ivan, Fransiskus Xaverius, Zhou, Xinrui, Lau, Suk Hiang, Rashid, Shamima, Teo, Jasmine S. M., Lee, Hong Kai, Koay, Evelyn S., Chan, Kwai Peng, Leo, Yee Sin, Chen, Mark I. Cheng, Kwoh, Chee Keong, Chow, Vincent T.

“…Background: This study compared the genomes of influenza viruses that caused mild infections among outpatients and severe infections among hospitalized patients in Singapore, and characterized their molecular evolution and receptor-binding specificity. Methods: The complete genomes of influenza A/H1N1, A/H3N2 and B viruses that caused mild infections among outpatients and severe infections among inpatients in Singapore during 2012–2015 were sequenced and characterized. …”
Get full text

Quantitative single-molecule study reveals site-specific photo-oxidation activities and kinetics on 2D g-C₃N₄ by Wu, Shuyang, Madridejos, Jenica Marie L., Lee, Jinn-Kye, Xu, Rong, Lu, Yunpeng, Zhang, Zhengyang

Get full text

Dengue Serotype Cross-Reactive, Anti-E Protein Antibodies Confound Specific Immune Memory for 1 Year after Infection by Toh, Ying Xiu, Gan, Victor, Balakrishnan, Thavamalar, Zuest, Roland, Poidinger, Michael, Wilson, Solomonraj, Appanna, Ramapraba, Thein, Tun Linn, Ong, Adrian Kheng-Yeow, Ng, Lee Ching, Leo, Yee Sin, Fink, Katja

“…Since secondary patients rapidly produced antibodies specific for the virus envelope (E) protein, an E-specific ELISA was superior compared to a virus particle-specific ELISA to identify patients with secondary infections. …”
Get full text
Get full text

Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity by Mouchemore, KA, Sampaio, N, Murrey, MW, Stanley, ER, Lannutti, BJ, Pixley, FJ

“…Treatment with p110δ‐specific inhibitors demonstrates that the hematopoietically enriched isoform, p110δ, mediates CSF‐1‐regulated spreading and invasion in macrophages. …”

Development of a Highly Specific RecombinantToxocara canis Second-Stage Larva Excretory-Secretory Antigen for Immunodiagnosis of Human Toxocariasis by Yamasaki, Hiroshi, Araki, Kunioki, Lim, Patricia Kim Chooi, Zasmy, Ngah

“…The specificity of the recombinant Toxocara canis antigen developed for the immunodiagnosis of human toxocariasis was compared with that of the excretory-secretory antigen from T. canis second-stage larvae (TES) by enzyme-linked immunosorbent assay. …”
Get full text

Translation of culture-specific items in foreign publicity texts : a case study of a bite of China II episode 1 & 2 by Huang, Jingjing

“…The most obvious differences in cultures exist in the culture specific items (CSIs), which leads to complexities in transferring the semantic meanings and cultural concepts from one culture to another. …”
Get full text

The role of dendritic cells in determining the breadth and epitope specificity of the initial CD8+ T cell response during acute HIV-1 infection by Partridge, T

“…The earliest CD8⁺ T cell responses decrease in magnitude as viraemia begins to decline, and are followed by delayed expansion of subsequent waves of responses of broader epitope-specificity. In this thesis, the hypotheses that prevalent presentation of Nef-derived epitopes by dendritic cells (DCs) favours priming of Nef-biased CD8⁺ T cell responses in AHI, and that impairments in DC function after the first responses are primed delay expansion of responses of additional specificities, were explored. …”

Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records by Cardwell, CR, Ranger, TA, Labeit, AM, Coupland, CAC, Hicks, B, Hughes, C, McMenamin, Ú, Mei, XW, Murchie, P, Hippisley-Cox, J

“…Therefore, we systematically examined HRT use and cancer-specific mortality in women with 17 site-specific cancers.…”

Whole-cell phenotypic screening of Medicines for Malaria Venture Pathogen Box identifies specific inhibitors of Plasmodium falciparum late-stage development and egress by Patra, Alok Tanala, Hingamire, Tejashri, Belekar, Meenakshi A., Xiong, Aoli, Subramanian, Gowtham, Bozdech, Zbynek, Preiser, Peter, Shanmugam, Dhanasekaran, Chandramohanadas, Rajesh

“…We report a systematic, cellular phenotype-based antimalarial screening of the Medicines for Malaria Venture Pathogen Box collection, which facilitated the identification of specific blockers of late-stage intraerythrocytic development of Plasmodium falciparum First, from standard growth inhibition assays, we identified 173 molecules with antimalarial activity (50% effective concentration [EC50] ≤ 10 μM), which included 62 additional molecules over previously known antimalarial candidates from the Pathogen Box. …”
Get full text

Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell-specific β-arrestin 2 knockout mice by Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra

“…Here, we have assessed in vivo glycemic responses to the pharmacological GLP-1R agonist exendin-4 in adult β cell-specific β-arrestin 2 knockout (KO) mice. KOs displayed a sex-dimorphic phenotype consisting of weaker acute responses that improved 6 hours after agonist injection. …”
Get full text

The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore by Padmapriya, Natarajan, Bernard, Jonathan Y., Tan, Sarah Yi Xuan, Chu, Anne H. Y., Goh, Claire Marie Jie Lin, Tan, Shuen Lin, Shek, Lynette P., Chong, Yap Seng, Tan, Kok Hian, Chan, Shiao-Yng, Yap, Fabian, Godfrey, Keith M., Lee, Yung Seng, Meaney, Michael J., Eriksson, Johan G., Tan, Chuen Seng, Law, Evelyn C., Müller-Riemenschneider, Falk

“…Objective: We investigated the prospective associations of accelerometer-measured 24 h-movement behaviors and domain-specific PA and SB with executive function and academic achievement among school-aged children in Singapore. …”
Get full text

Adenovirus-associated health risks for recreational activities in a multi-use coastal watershed based on site-specific quantitative microbial risk assessment by Kundu, Arti., McBride, Graham., Wuertz, Stefan.

“…We used site-specific quantitative microbial risk assessment (QMRA) to assess the probability of adenovirus illness for three groups of swimmers: adults with primary contact, children with primary contact, and secondary contact regardless of age. …”
Get full text
Get full text

Immuno-protective effect of commercial IBD vaccines against emerging novel variant infectious bursal disease virus in specific-pathogen-free chickens by Aliyu, Hayatuddeen Bako, Hamisu, Tasiu Mallam, Hair-Bejo, Mohd, Omar, Abdul Rahman, Ideris, Aini

“…Objective: This study examined the immune protection of immune-complex (Vaccine A) and attenuated live (Vaccine B) IBD vaccines in specific-pathogen-free (SPF) chickens against a novel Malaysian variant IBD virus (vaIBDV) challenge. …”
Get full text