Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…LRR- and EPTP-specific effects were evaluated by patch-clamp recordings in cultured hippocampal neurons and compared with biophysical neuron modeling. …”

Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals by Vavoulis, DV, Cutts, A, Thota, N, Brown, J, Sugar, R, Rueda, A, Ardalan, A, Howard, K, Matos Santo, F, Sannasiddappa, T, Miller, B, Ash, S, Liu, Y, Song, C, Nicholson, BD, Dreau, H, Tregidgo, C, Schuh, A

“…We conduct a diagnostic accuracy study across multiple cancer types in symptomatic patients, achieving 94.9% sensitivity and 88.8% specificity. Matched tumour biopsies are used for validation, not for guiding the analysis, imitating an early detection scenario. …”

In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery by Kwong, H, Borrow, P

Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation by McElroy, Kerensa E., Hui, Janice G. K., Woo, Jerry K. K., Luk, Alison W. S., Webb, Jeremy S., Kjelleberg, Staffan, Rice, Scott A., Thomas, Torsten

“…Mutations were found to be strain specific: the mucoid strain 18A experienced mutations in alginate production genes and a c-di-GMP regulator gene; while PA01 acquired mutations in PilT and PilY1, possibly in response to a rapid expansion of a lytic Pf4 bacteriophage, which may use type IV pili for infection. …”
Get full text
Get full text

Improving social sustainability through context-specific mixed-use high-rise apartments in tiong nam / by Elaine, Lee Mei Lian, 1989-, author 610717, Tareef Hayat Khan, supervisor 604967, Syed Ahmad Iskandar Syed Ariffin, supervisor 643448, Fakulti Alam Bina 8041

Improving social sustainability through context-specific mixed-use high-rise apartments in tiong nam / by Elaine, Lee Mei Lian, 1989-, author 610717

Discovery of glucose-specific, peptide-based carbohydrate mimics using phage displayed random peptide libraries. by Yu, Limin.

“…Phage displayed random peptide libraries were used to discover peptides which functionally mimic the monosaccharide glucose by screening these libraries against glucose-specific lectins. Although the screening of phage display libraries against single lectins has been previously reported, debate exists whether the resulting peptides are indeed true sugar mimics or merely act as ligands for the targeted lectin. …”
Get full text

Distilling crowd knowledge from software-specific Q&A discussions for assisting developers’ knowledge search by Chen, Chunyang

“…In addition, the decay of information quality such as misspelling, inconsistency, and abuse of domain-specific abbreviations aggravates the search performance. …”
Get full text

Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket by Kannan, Srinivasaraghavan, Venkatachalam, Gireedhar, Lim, Hong Hwa, Surana, Uttam, Verma, Chandra

“…Our study characterizes a druggable allosteric pocket which appears to be specific to certain oncogenic mutants of the EGFR and holds therapeutic potential.…”
Get full text
Get full text

DNA extraction methodologies for ultra long nanopore sequencing to determine chromosome specific rodent telomere lengths by Kidd, Elliot, Mooruth, Ravi, Meimaridou, Eirini, Walley, Andrew, Fairbrother, Una

“…Direct sequencing of highly repetitive stretches of DNA is difficult, using specific DNA extraction techniques and adaptive sampling and tagging approaches for targeted enrichment has generated chromosome specific ultralong reads in rodents.…”
Get full text

An epitope-specific LGI1-autoantibody enhances neuronal excitability by modulating Kv1.1 channel by Extrémet, J, El Far, O, Ankri, N, Irani, SR, Debanne, D, Russier, M

“…Patient-derived recombinant monoclonal antibodies (mAbs) are ideal reagents to study whether domain-specific LGI1-autoantibodies induce epileptiform activities in neurons and their downstream mechanisms. …”

Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies by Hunter, B, Li, M, Parker, BL, Koay, YC, Harney, DJ, Pearson, E, Cao, J, Chen, GT, Guneratne, O, Smyth, GK, Larance, M, O’Sullivan, JF, Lal, S

“…To better understand ventricle-specific molecular changes influencing heart failure development, we first performed unbiased quantitative mass spectrometry on pre-mortem non-diseased human myocardium to compare the metabolome and proteome between the normal left and right ventricles. …”

Maternal Death Surveillance and Response in Sudan: an evidence-based, context-specific optimisation to improve maternal care by Altijani Osman Abbakar, N

Structural dynamics of the ubiquitin specific protease UPS30 in complex with a cyanopyrrolidine-containing covalent inhibitor by O’Brien, DP, Jones, HBL, Shi, Y, Guenther, F, Vendrell, I, Viner, R, Brennan, PE, Mead, E, Zarganes-Tzitzikas, T, Davis, JB, Pinto-Fernández, A, England, KS, Murphy, EJ, Turnbull, AP, Kessler, BM

A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment by Viz-Lasheras, S, Gómez-Carballa, A, Bello, X, Rivero-Calle, I, Dacosta, AI, Kaforou, M, Habgood-Coote, D, Cunnington, AJ, Emonts, M, Herberg, JA, Wright, VJ, Carrol, ED, Paulus, SC, Zenz, W, Kohlfürst, DS, Schweintzger, N, Van der Flier, M, de Groot, R, Schlapbach, LJ, Agyeman, P, Pollard, AJ, Fink, C, Kuijpers, TT, Anderson, S

“…Current diagnostic tests are time-consuming and have low specificity, leading clinicians to administer empirical antibiotics. …”

Identification and validation of novel breed-specific biomarker for the purpose of village chicken authentication using genomics approaches by Nematbakhsh, Sara, Pei, Chong Pei, Nordin, Noordiana, Selamat, Jinap, Idris, Lokman Hakim, Abdull Razis, Ahmad Faizal

“…Therefore, developing a breed-specific authentication method is crucial for preventing food fraud in the poultry industry. …”
Get full text

Constructing quantum angular momentum l̂3 in a specific direction by using the U(1) group by Rosli, Ahmad Aqwa, Mohd Shah, Nurisya

“…The purpose of this work is to investigate the mathematical structure of finite quantum angular momentum in a specific direction L3 which can be constructed from the representation of the U(1) group. …”
Get full text

Analyzing the challenges of developing English for Specific Purpose (ESP) courses for Sino-Foreign Cooperative Educational Programs by Huang, Zizhe, Mustakim, Siti Salina, Ghazali, Norliza

“…The development of English for Specific Purposes (ESP) courses is directly related to the quality of talent cultivation in Sino-foreign cooperative educational programs. …”
Get full text

Effects of functional training on tennis-specific physical fitness and functional movement screen in junior tennis players by Xiao, Wensheng, Bai, Xiaorong, Soh, Kim Geok, Zhang, Yang

“…At baseline, after six weeks, and after 12 weeks (T12), the participants' tennis-specific physical fitness and functional movement screen (FMS) were evaluated. …”
Get full text

Bioinformatics tools assist in the screening of potential porcine-specific peptide biomarkers of gelatin and collagen for halal authentication by Abdul Shukor, Muhd Syarafuddin, Abdullah, Mohd Faiz Foong, Zainal Abidin, Siti Aimi Sarah, Yuswan, Mohd Hafis, Mohd Ismail, Azilawati

“…This study aims to identify the specific peptide biomarkers by employing bioinformatics technique which can be applied to identify gelatin and collagen sources with the aid of mass spectrometry. …”
Get full text