Surface plasmon resonance (SPR) enhanced biosensors by Zhang, Jinling

“…The sensitivity and specificity are mainly related to the sensing mechanism and binding characteristics. The sensing principle in most of my works are SPR and SPR enhanced fluorescence. …”
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Biomolecular hydration in protein-protein interaction, protein stability and aggregation and lead optimization : computational studies by Mohan Rajan Pradhan

“…During the process of drug discovery, the question of which waters that exist in a binding site need to be displaced by the designed ligand is of critical importance and as yet has no universal solution. …”
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Development of high-affinity peptide-drug conjugates for investigating the TRIM24 PHD and bromodomain by Platt, MA

“…</p> <br> <p>The PDCs showed low nanomolar^® IC₅₀ values for displacement of a TRIM24 PHD- and BRD-binding peptide (H3K9Me₃K18Ac), and exhibited avidity for TRIM24, which arises from simultaneous in <em>cis</em> binding to the PHD and BRD. …”

Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site by Banach, Bailey B, Pletnev, Sergei, Olia, Adam S, Xu, Kai, Zhang, Baoshan, Rawi, Reda, Bylund, Tatsiana, Doria-Rose, Nicole A, Nguyen, Thuy Duong, Fahad, Ahmed S, Lee, Myungjin, Lin, Bob C, Liu, Tracy, Louder, Mark K, Madan, Bharat, McKee, Krisha, O’Dell, Sijy, Sastry, Mallika, Schön, Arne, Bui, Natalie, Shen, Chen-Hsiang, Wolfe, Jacy R, Chuang, Gwo-Yu, Mascola, John R, Kwong, Peter D, DeKosky, Brandon J

“…Structural analyses demonstrate that the improved paratope expands the FP binding groove to accommodate diverse FP sequences of different lengths while also recognizing the HIV-1 Env backbone. …”
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Glycosylated copper sulfide nanocrystals for targeted photokilling of bacteria in the near‐infrared II window by Hou, Shuai, Mahadevegowda, Surendra Hittanahalli, Mai, Van Cuong, Chan‐Park, Mary Bee Eng, Duan, Hongwei

“…This approach can be readily generalized to the targeting of other pathogens which have highly specific carbohydrate‐binding lectins.…”
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Structural insights into polyamine spermidine uptake by the ABC transporter PotD-PotABC by Qiao, Zhu, Do, Phong Hoa, Yeo, Joshua Yi, Ero, Rya, Li, Zhuowen, Zhan, Liying, Basak, Sandip, Gao, Yong-Gui

“…The PotD-PotABC protein complex in Escherichia coli, belonging to the adenosine triphosphate-binding cassette transporter family, is a spermidine-preferential uptake system. …”
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An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion by Collins, Katherine M., Kainov, Yaroslav A., Christodolou, Evangelos, Ray, Debashish, Morris, Quaid, Hughes, Timothy, Taylor, Ian A., Makeyev, Eugene V., Ramos, Andres

“…RBM10 is an RNA-binding protein that plays an essential role in development and is frequently mutated in the context of human disease. …”
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Protective Capacity of the Human Anamnestic Antibody Response during Acute Dengue Virus Infection by Xu, Meihui, Züst, Roland, Toh, Ying Xiu, Pfaff, Jennifer M., Kahle, Kristen M., Davidson, Edgar, Doranz, Benjamin J., Velumani, Sumathy, Tukijan, Farhana, Wang, Cheng-I, Fink, Katja

“…The latter, largely serotype-cross-reactive antibodies, demonstrated increased stability of binding at pH 5. These antibodies possessed weak to moderate neutralization capacity in vitro but were the most efficacious in promoting the survival of infected mice. …”
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Comprehensive insights into Sitobion avenae preferences and performance on Pakistan’s wheat cultivars leading to identification of potential RNAi targets by Mukhtar, Ruhma, Afzal, Eijab, Noureen, Rabia, Zeeshan, Nadia, Afroz, Amber

“…Trypsin, cathepsin-B and carbonic anhydrases are connected to detoxification and digestion. While odorant binding proteins, salivary effector proteins, sodium channel proteins and ecdysone- induced proteins facilitate feeding process in S. avenae. …”
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Potential utilization of phenolic acid compounds as anti-inflammatory agents through TNF-α Convertase inhibition mechanisms: a network pharmacology, docking, and molecular dynamics... by Ekowati, Juni, Tejo, Bimo A., Maulana, Saipul, Kusuma, Wisnu Ananta, Fatriani, Rizka, Ramadhanti, Nabila Sekar, Norhayati, Novianty, Kholis Amalia, Sulistyowaty, Melanny Ika, Zubair, Muhammad Sulaiman, Yamauchi, Takayasu, Hamid, Iwan Sahrial

“…Among tested compounds, chlorogenic acid (−6.90 kcal/mol), rosmarinic acid (−6.82 kcal/mol), and ellagic acid (−5.46 kcal/mol) exhibited the strongest binding affinity toward TNF-α convertase. Furthermore, phenolic acid compounds demonstrated molecular binding poses similar to those of the native ligand, indicating their potential as inhibitors of TNF-α convertase. …”

Sygyzium claviflorum fruit extract preadipocyte differentiation inhibition in 3T3-L1 cells by Zohdi, Rozaini M., Adli, Muhammad A., Mukhtar, Shahida M., Awang Junaidi, Awang H., Bakar, Md Zuki A.

“…Moreover, SCFE suppressed sterol regulatory element binding protein-1 (SREBP-1), peroxisome proliferator-activated receptor-gamma (PPAR-γ), and CCAAT/enhancer-binding protein-alpha (C/EBP-α) gene expressions during preadipocyte differentiation into adipocytes. …”
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Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm by Ng, Calista Keow Leng, Herath, Wishva, Lili, Sun, Hutchins, Andrew P, Robson, Paul, Kolatkar, Prasanna R, Stanton, Lawrence W, Aksoy, Irene, Jauch, Ralf, Chen, Jiaxuan, Dyla, Mateusz, Divakar, Ushashree, Bogu, Gireesh K, Teo, Roy

“…We show that Sox17 partners with Oct4 and binds to a unique ‘compressed’ Sox/Oct motif that earmarks endodermal genes. …”
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Atherogenesis and plaque rupture, surface/interface-related phenomena by Siegel, G., Berkholz, J., Klüßendorf, D., Knosalla, C., Zakrzewicz, A., Ermilov, E., Malmsten, M., Lindman, Bjorn

“…These lipoproteins easily aggregate, bind to their receptor heparan sulfate proteoglycan and calcify to arteriosclerotic nanoplaques (ternary complexes). …”
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Soy-derived phytochemical genistein modifies chromatome topology to restrict cancer cell proliferation by Dutta, Bamaprasad, Park, Jung Eun, Qing, Ivan Toh Yi, Kon, Oi Lian, Sze, Siu Kwan

“…Prolonged phytochemical exposure conferred heritable changes in the binding topology of key epigenetic regulators including ATRX, SUV39H1/H2, and HP1BP3 that are preserved in untreated progeny, resulting in sustained downregulation of proliferation genes and reduced cell growth. …”
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Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering by Heinrich, Frank, Nanda, Hirsh, Goh, Haw Zan, Bachert, Collin, Lösche, Mathias, Linstedt, Adam D.

“…In vivo, the membrane association of GRASP proteins is conferred by the simultaneous insertion of an N-terminal myristic acid and binding to a Golgi-associated binding partner. In our assay, the latter contact was replaced using a C-terminal hexa-His moiety, which bound to Ni2+-conjugated lipids incorporated into a substrate-supported bilayer lipid membrane. …”
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Lipopolysaccharide neutralizing peptide–porphyrin conjugates for effective photoinactivation and intracellular imaging of gram-negative bacteria strains by Liu, Fang, Soh, Annie Yan Ni, Lim, Yingjie, Mohanram, Harini, Bhattacharjya, Surajit, Xing, Bengang

“…A simple and specific strategy based on the bioconjugation of a photosensitizer protophophyrin IX (PpIX) with a lipopolysaccharide (LPS) binding antimicrobial peptide YI13WF (YVLWKRKRKFCFI-Amide) has been developed for the effective fluorescent imaging and photodynamic inactivation of Gram-negative bacterial strains. …”
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The influence of polarisation on the behaviour of anions within ion channels and nanopores by Phan, LX

“…Expanding upon this, a hydrophobic Clˉ-pumping rhodopsin binding site was surveyed using different levels of granularity for capturing polarisation. …”

Exploring effects of calcitonin and procalcitonin in cardiomyocytes by Moreira, LMF

“…I also show that CT, via binding to CTR expressed in CMs, increased cAMP production, indicating Gαs-coupling of CTRs in human CMs. …”

Synthetic post-translational protein modification as a switch for activity by Faulkner, SC

“…Functional evidence from in vivo observations suggests that the chromodomain reader protein MRG15 should preferentially bind H3K36me3 over its dimethyl counterpart. However, in vitro studies using peptides or isolated H3 as a substrate have failed to recapitulate this observation. …”

Gene-primer a PCR primer design program by Kok, Wui Lim.

“…In summary, selected primers adhered to both physico-chemical criteria and also display specificity to intended binding site in the genome.…”
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