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    Development of human enterovirus 71 nano calcium phosphate adjuvanted candidate vaccine for parenteral and mucosal delivery

    Development of human enterovirus 71 nano calcium phosphate adjuvanted candidate vaccine for parenteral and mucosal delivery by Saeed Ahmed, Mohamed Ibrahim

    Published 2015
    “…The alginate formulations had no effect on the IgA levels, it seems the vaccine epitopes were trapped in the alginate composite. The effect of joint dual immunization parenteral and mucosal routes (nano-CaP-HEV71 killed-virus (ID) and vaccine encapsulated in chitosan through the buccal delivery) to the same animals induced enhanced both types of systemic and mucosal antibody responses, as displayed in serum IgG and salivary IgA antibody levels towards the vaccine. …”
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