Real-world effectiveness of sotrovimab and remdesivir for early treatment of high-risk hospitalized COVID-19 patients: a propensity score adjusted retrospective cohort study by Koh, Lin Pin, Chua, Siang Li, Vasoo, Shawn, Toh, Matthias Paul Han Sim, Cutter, Jeremy Nicholas, Nah, Puay Hoon, Leo, Yee Sin, Tay, Jun Xin, Young, Barnaby Edward, Lye, David C., Ong, Sean W. X.

“…In unvaccinated patients, both remdesivir and sotrovimab treatment were protective (adjusted odds ratio [aOR] 0.19, 95% CI 0.064-0.60 and 0.18 [95% CI 0.066-0.47]), respectively. …”
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Roux-en-Y gastric bypass, adjustable gastric banding, or sleeve gastrectomy for severe obesity: the By-Band-Sleeve multi-centre, open label, three-group randomised controlled trial by Agrawal, S, Ahmed, A, Andrews, RC, Fermont, JM, Koleva-Kolarova, R, Pouwels, K, Wordsworth, S

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…<p><b>Methods</b></p> The GBD 2021 disease and injury burden analysis estimated years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries using 100 983 data sources. …”

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Here we study two prototypical ruthenium-arene agents—the cytotoxic antiprimary tumour compound [(η6-p-cymene)Ru(ethylene-diamine)Cl]PF6 and the relatively non-cytotoxic antimetastasis compound [(η6-p-cymene)Ru(1,3,5-triaza-7-phosphaadamantane)Cl2]—and discover that the former targets the DNA of chromatin, while the latter preferentially forms adducts on the histone proteins. Using a novel ‘atom-to-cell’ approach, we establish the basis for the surprisingly site-selective adduct formation behaviour and distinct cellular impact of these two chemically similar anticancer agents, which suggests that the cytotoxic effects arise largely from DNA lesions, whereas the protein adducts may be linked to the other therapeutic activities. …”
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Alkaline earth complexes supported by chelating diamido ligands by Haynes, M

“…These were compared with a series of THF adducts characterised in collaboration with Prof. …”

An energy-efficient self-adaptive duty cycle MAC protocol for traffic-dynamic wireless sensor networks by Zhao, Yi Zhi, Ma, Maode, Miao, Chun Yan

“…When network experience with very low or very high traffic load, the protocol further adjusts duty cycle dynamically based on the traffic load, thus reducing inefficient duty cycle or reduce end-to-end delay. …”
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Systematic Studies on the Chelating Ligand Effects of Novel Borafluoronium Ions by Allen, Marissa D.

“…Further investigations into the coordination of other bisphosphine ligands, such as dppe, rac-BINAP, and Xantphos, resulted in the formation of Lewis adducts rather than the desired borafluoronium ions. …”
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Molecular recognition in protein-DNA assemblies by Davey, Curt Alexander

“…Although DNA sequence seemed to dominate site preference, histone octamer association was capable of modulating adduct formation by both inhibiting or promoting platination at certain sites. …”
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An unusual [4 + 4] cycloadduct from an o-quinodimethane : characterisation and computational studies by Mohamed Husaini Abdul Rahman, Ramabhadran, Raghunath O., Collier, Steven J., Storr, Richard C., Bates, Roderick Wayland

“…Trapping of a pyrimidinone-derived o-quinodimethane with tetraphenylcyclopentadienone gives a mixture of the [4 + 2] and formal [4 + 4] adducts. Computational studies show that the latter arises by a sequence of [4 + 2] cycloaddition, homolysis, radical recombination to a spiro-tetrahydrofuran and Claisen rearrangement under the thermolytic conditions.…”
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Essays in dynamic pricing, channel control and channel competition by Song, Boqian

“…First, we study the service unbundling issue of a seller who separates the sales of a fixed-priced add-on and dynamically adjusts the price of the capacitated basic service along the horizon. …”
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Universal Adaptive Control of Nonlinear Systems by Lopez, Brett T., Slotine, Jean-Jacques E.

“…This letter develops a new direct adaptive control framework that extends the certainty equivalence principle to general nonlinear systems with unmatched model uncertainties. The approach adjusts the rate of adaptation online to eliminate the effects of parameter estimation transients on stability. …”
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Semantic constraint on preposition incorporation of postverbal locative PPs in Mandarin Chinese by Peck, Jeeyoung, Lin, Jingxia

“…Previous studies claim that adjunct phrases which quantify an event, such as event delimiters, may behave like arguments (“the delimiter hypothesis”). …”
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GROUP III permethylindenyl-phenoxy complexes for biorenewable polymer synthesis by Hayden, JA

“…Coordination complexes of 4-coodinate PHENI* scandium monomer adducts of <em>L</em>-lactide, ϵ-caprolactone, and ω-pentadecalactone are discussed.…”

The augmented human — seeing sounds by Lim, Nicole Sze Ting

“…Through a user-friendly web interface, a user uploads a video and adjusts settings for its processing. Speech separation and speech recognition models are then applied to produce an annotated video with captions differentiated by speaker. …”
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Synthesis, structural studies and ligand influence on the stability of aryl-NHC stabilised trimethylaluminium complexes by Wu, Melissa M., Gill, Arran M., Lu, Yunpeng, Laura, Falivene, Li, Yongxin, Rakesh, Ganguly, Luigi, Cavallo, Felipe, García

“…Treatment of a series of aromatic NHCs (IMes, SIMes, IPr and SIPr) with trimethylaluminium produced their corresponding Lewis acid–base adducts: IMes·AlMe3 (1), SIMes·AlMe3 (2), IPr·AlMe3 (3), and SIPr·AlMe3 (4). …”
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Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters by Yan, Lin, Han, Zhiqiang, Zhu, Bo, Yang, Caiyun, Tan, Choon-Hong, Jiang, Zhiyong

“…A series of important fluorinated adducts, with chiral quaternary carbon centres containing a fluorine atom, was achieved in good yields (up to 93%), with good to excellent enantioselectivities (up to 96% ee) and moderate diastereoselectivities (up to 4:1 dr).…”
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Thermal management of 3D integrated circuits with microchannel-based liquid cooling by Qian, Hanhua

“…A runtime proactive thermal management scheme, which adjusts flow rate according to predicted future cooling demand is proposed based on this thermal model. …”
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Parallel Dynamic Maximal Matching by Ghaffari, Mohsen, Trygub, Anton

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Maximizing DRL-based energy efficiency in IRS-NOMA using a DDPG algorithm for the next generation of wireless communications by Audah, Kamil, Noordin, Nor K., Hussein, Wala'a, Rasid, Mod Fadlee B. A., Sali, Aduwati, Flah, Aymen

“…This study focuses on a Deep Deterministic Policy Gradient (DDPG) algorithm that intelligently adjusts IRS phase-shift matrices and access point beamforming in NOMA DT. …”
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Evaluating Prediction Mechanisms: A Profitability Test by Sethi, Rajiv, Seager, Julie, Cai, Emily, Benjamin, Daniel, Morstatter, Fred, Bobrownicki, Olivia, Cheng, Yuqi, Kumar, Anushka, Wanganoo, Anusha

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