Micro-dosing psychedelics as a plausible adjunct to psychosexual and couple’s therapy: a qualitative insight by Jacobs, Lucy, Banbury, Samantha, Lusher, Joanne

“…Conclusion: These findings point to micro-dosing psychedelics as offering a potentially beneficial adjunct to psychosexual and couple’s therapy; potentiating relationship and sexual satisfaction. …”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Ferrari, AJ, Santomauro, DF, Aali, A, Lacey, BWH, Rodriguez, JAB

“…<p><b>Methods</b></p> The GBD 2021 disease and injury burden analysis estimated years lived with disability (YLDs), years of life lost (YLLs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries using 100 983 data sources. …”

Differentiating people with schizophrenia from healthy controls in a developing country: an evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool by Tran, Bach Xuan, Nguyen, Tham Thi, Boyer, Laurent, Fond, Guillaume, Auquier, Pascal, Nguyen, Hao Si Anh, Tran, Ha Thi Nhi, Nguyen, Hung Manh, Choi, Jongkwan, Le, Huong Thi, Latkin, Carl A., Nathan, Kalpana Isabel, Husain, Syeda F., McIntyre, Roger S., Ho, Cyrus S. H., Zhang, Melvyn, Ho, Roger C. M.

“…Introduction: This study aimed to evaluate portable functional near-infrared spectroscopy (fNIRS) device as an adjunct diagnostic tool in Vietnam to assess hemodynamics when people with schizophrenia and healthy controls performed cognitive tasks. …”
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An energy-efficient self-adaptive duty cycle MAC protocol for traffic-dynamic wireless sensor networks by Zhao, Yi Zhi, Ma, Maode, Miao, Chun Yan

“…When network experience with very low or very high traffic load, the protocol further adjusts duty cycle dynamically based on the traffic load, thus reducing inefficient duty cycle or reduce end-to-end delay. …”
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Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records by Cardwell, CR, Ranger, TA, Labeit, AM, Coupland, CAC, Hicks, B, Hughes, C, McMenamin, Ú, Mei, XW, Murchie, P, Hippisley-Cox, J

“…In particular, no increase was observed in common cancers including lung (adjusted HR = 0.98 95% CI 0.90, 1.07), colorectal (adjusted HR = 0.79 95% CI 0.70, 0.90), and melanoma (adjusted HR = 0.77 95% CI 0.58, 1.02).…”

Ligand substitutions between ruthenium–cymene compounds can control protein versus DNA targeting and anticancer activity by Davey, Curt Alexander, Adhireksan, Zenita, Davey, Gabriela E., Campomanes, Pablo, Groessl, Michael, Clavel, Catherine M., Yu, Haojie, Nazarov, Alexey A., Yeo, Charmian Hui Fang, Ang, Wee Han, Dröge, Peter, Rothlisberger, Ursula, Dyson, Paul J.

“…Here we study two prototypical ruthenium-arene agents—the cytotoxic antiprimary tumour compound [(η6-p-cymene)Ru(ethylene-diamine)Cl]PF6 and the relatively non-cytotoxic antimetastasis compound [(η6-p-cymene)Ru(1,3,5-triaza-7-phosphaadamantane)Cl2]—and discover that the former targets the DNA of chromatin, while the latter preferentially forms adducts on the histone proteins. Using a novel ‘atom-to-cell’ approach, we establish the basis for the surprisingly site-selective adduct formation behaviour and distinct cellular impact of these two chemically similar anticancer agents, which suggests that the cytotoxic effects arise largely from DNA lesions, whereas the protein adducts may be linked to the other therapeutic activities. …”
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Alkaline earth complexes supported by chelating diamido ligands by Haynes, M

“…These were compared with a series of THF adducts characterised in collaboration with Prof. …”

Essays in dynamic pricing, channel control and channel competition by Song, Boqian

“…First, we study the service unbundling issue of a seller who separates the sales of a fixed-priced add-on and dynamically adjusts the price of the capacitated basic service along the horizon. …”
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Universal Adaptive Control of Nonlinear Systems by Lopez, Brett T., Slotine, Jean-Jacques E.

“…This letter develops a new direct adaptive control framework that extends the certainty equivalence principle to general nonlinear systems with unmatched model uncertainties. The approach adjusts the rate of adaptation online to eliminate the effects of parameter estimation transients on stability. …”
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Systematic Studies on the Chelating Ligand Effects of Novel Borafluoronium Ions by Allen, Marissa D.

“…Further investigations into the coordination of other bisphosphine ligands, such as dppe, rac-BINAP, and Xantphos, resulted in the formation of Lewis adducts rather than the desired borafluoronium ions. …”
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Severe malarial thrombocytopenia : a risk factor for mortality in Papua, Indonesia by Lampah, Daniel A., Yeo, Tsin W., Malloy, Michael, Kenangalem, Enny, Douglas, Nicholas M., Ronaldo, Donny, Sugiarto, Paulus, Simpson, Julie A., Poespoprodjo, Jeanne Rini, Anstey, Nicholas M., Price, Ric N.

“…Patients with severe malarial anemia alone (hemoglobin level, <5 g/dL) had an adjusted OR for death of 4.93 (95% CI, 3.79–6.42), those with severe malarial thrombocytopenia alone had an adjusted OR of 2.77 (95% CI, 2.20–3.48), and those with both risk factors had an adjusted OR of 13.76 (95% CI, 10.22–18.54; P < .001). …”
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Phenotypic vs. genetic mismatch of BMI and type 2 diabetes: evidence from two perspective cohort studies by Li, A, Gong, S, Yu, C, Pei, P, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Du, H, Yang, X, Hou, W, Chen, J, Chen, Z, Lv, J, Li, L, Sun, D, China Kadoorie Biobank Collaborative Group

“…We therefore used data from the China Kadoorie Biobank and UK Biobank and calculated BMI-PGM for each participant as the difference between the percentile for adjusted BMI at baseline and the percentile for adjusted polygenic risk score for BMI. …”

Optimal portfolio management. by Lim, Xue Jing., Ng, Jie Wen., Peh, Ying Jie.

“…We conclude that the 2 combinations: value-weighted lowest PE portfolio and value-weighted lowest PTB portfolio, generates best risk-adjusted returns, as measured by Sharpe ratio. However, these results are sensitive to changes in the sample used, investment horizon, short-sales constraints.…”
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Molecular recognition in protein-DNA assemblies by Davey, Curt Alexander

“…Although DNA sequence seemed to dominate site preference, histone octamer association was capable of modulating adduct formation by both inhibiting or promoting platination at certain sites. …”
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An unusual [4 + 4] cycloadduct from an o-quinodimethane : characterisation and computational studies by Mohamed Husaini Abdul Rahman, Ramabhadran, Raghunath O., Collier, Steven J., Storr, Richard C., Bates, Roderick Wayland

“…Trapping of a pyrimidinone-derived o-quinodimethane with tetraphenylcyclopentadienone gives a mixture of the [4 + 2] and formal [4 + 4] adducts. Computational studies show that the latter arises by a sequence of [4 + 2] cycloaddition, homolysis, radical recombination to a spiro-tetrahydrofuran and Claisen rearrangement under the thermolytic conditions.…”
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The augmented human — seeing sounds by Lim, Nicole Sze Ting

“…Through a user-friendly web interface, a user uploads a video and adjusts settings for its processing. Speech separation and speech recognition models are then applied to produce an annotated video with captions differentiated by speaker. …”
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Semantic constraint on preposition incorporation of postverbal locative PPs in Mandarin Chinese by Peck, Jeeyoung, Lin, Jingxia

“…Previous studies claim that adjunct phrases which quantify an event, such as event delimiters, may behave like arguments (“the delimiter hypothesis”). …”
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Thermal management of 3D integrated circuits with microchannel-based liquid cooling by Qian, Hanhua

“…A runtime proactive thermal management scheme, which adjusts flow rate according to predicted future cooling demand is proposed based on this thermal model. …”
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Optimizing mechanical ventilation: Personalizing mechanical power to reduce ICU mortality ‐ a retrospective cohort study by Alkhalifah, AS, Rumindo, K, Brincat, E, Blanchard, F, Helleberg, J, Clarke, D, Popoff, B, Duranteau, O, Mohamed, ZU, Senosy, A

“…Safe upper limits for IBW-adjusted MP varied across hypoxemia groups. The XGBoost model showed the highest predictive accuracy for ICU mortality. …”

GROUP III permethylindenyl-phenoxy complexes for biorenewable polymer synthesis by Hayden, JA

“…Coordination complexes of 4-coodinate PHENI* scandium monomer adducts of <em>L</em>-lactide, ϵ-caprolactone, and ω-pentadecalactone are discussed.…”