Causal inference in health and disease: a review of the principles and applications of Mendelian randomization by Lovegrove, CE, Howles, SA, Furniss, D, Holmes, MV

“…This review provides a framework to enhance understanding of how MR may be used to triangulate evidence and progress research in bone and mineral metabolism as we strive to infer causal effects in health and disease.…”

Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype by de Vos, Ivo J. H. M., Goggi, Julian L., Wilson, Gabrielle R., Stegmann, Alexander P. A., Amor, David J., Dunn, Norris Ray, Carney, Thomas James, Lockhart, Paul J., Coull, Barry J., van Steensel, Maurice A. M., Tao, Evelyn Yaqiong, Ong, Sheena Li Ming, Scerri, Thomas, Low, Chernis Guai Mun, Wong, Arnette Shi Wei, Grussu, Dominic, van Geel, Michel, Janssen, Renske, Bahlo, Melanie

“…Notably, the zebrafish model will be a valuable tool for developing novel therapeutic approaches to a devastating bone disorder.…”
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Morphological multiparameter filtration and persistent homology in mitochondrial image analysis by Chung, Yu-Min, Hu, Chuan-Shen, Sun, Emily, Tseng, Henry C.

“…Mutations in the autophagy gene Optineurin (OPTN) are associated with primary open-angle glaucoma (POAG), amyotrophic lateral sclerosis (ALS), and Paget's disease of the bone, but the pathophysiological mechanism is unclear. …”
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Comparison of a simplified skin pointer device compared with a skeletal marker for knee rotation laxity : a cadaveric study using a rotation-meter by Puah, Ken Lee, Yew, Andy Khye Soon, Chou, Siaw Meng, Lie, Denny Tijauw Tjoen

“…METHODS : Six pairs of cadaveric legs were mounted on a knee rotation jig. One Kirscher wire was driven into the tibial tubercle as a bone marker and a skin pointer was attached. …”
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Clinical, genetic and omics-based biomarkers that might support the identification of the development of psoriatic arthritis in individuals with psoriasis – a narrative review of t... by Grohmann, T, Vivekanantham, A, Coates, L, Pennington, S, FitzGerald, O

“…Furthermore, there are considerable delays in diagnosis and treatment of PsA, which lead to joint and bone deformation and chronic pain. It is therefore important to develop more precise diagnostic and screening tools. …”

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress by Vasudevarao, MD, Posadas Pena, D, Ihle, M, Bongiovanni, C, Maity, P, Geissler, D, Mohammadi, HF, Rall-Scharpf, M, Niemann, J, Mommersteeg, MTM, Redaelli, S, Happ, K, Wu, C, Beisaw, A, Scharffetter-Kochanek, K, D’Uva, G, Malek Mohammadi, M, Wiesmüller, L, Geiger, H, Weidinger, G

“…Surprisingly, we found that regenerating cardiomyocytes experience DNA replication stress, which represents one reason for declining tissue regeneration during aging in mammals. …”

The rise and fall of Britain’s golden cohort: how the remarkable generation of 1925-1934 had their lives cut short by austerity by Hiam, L, Dorling, D

“…The British born between 1925 and 1934 experienced exceptional improvements in their annual mortality; earning them the title ‘the Golden Cohort’. …”

Constructions of Japan and the Japanese : war, memory and foreign policy in Singapore by Liu, Joseph Woon Keong

“…The collaborative mode of memory was born of the political and economic engagements with Japan since Singapore’s independence. …”
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Rule Britannia: Brexit and the end of empire by Dorling, D, Tomlinson, S

“…In this wide-ranging and thoughtful analysis, now fully updated to cover the fallout from Brexit and the impact of coronavirus, Dorling and Tomlinson argue that if Britain can reconcile itself to its new place on the world stage, a new identity can be born from the ashes. <i>Rule Britannia</i> is a powerful call to leave behind the jingoistic ignorance of the past and build a fairer Britain, eradicating the inequality that blights our society and embracing our true strengths.…”

Review of the aetiologies of central nervous system infections in Vietnam by Brindle, HE, Choisy, M, Christley, R, French, N, Griffiths, M, Thai, PQ, van Doorn, HR, Nadjm, B

“…In particular, we focus on the most common pathogens in adults and children including Streptococcus suis which is associated with the consumption of raw pig products, and Japanese encephalitis virus, a mosquito-borne pathogen. We also discuss pathogens less commonly known to cause CNS infections in Vietnam but have been detected in neighbouring countries such as Orientia tsutsugamushi, Rickettsia typhi and Leptospira species and how these may contribute to the unknown causes in Vietnam. …”

Effectiveness of supervised versus self-directed rehabilitation for adults aged 50 years and over with ankle fractures: protocol for the AFTER trial by Keene, DJ, Achten, J, Forde, C, Png, ME, Grant, R, Draper, K, Appelbe, D, Tutton, E, Peckham, N, Dutton, SJ, Lamb, SE, Costa, ML

“…Participants will be randomized 1:1 using a web-based service to supervised rehabilitation (four to six one-to-one physiotherapy sessions of tailored advice and prescribed home exercise over three months), or self-directed rehabilitation (provision of advice and exercise materials that participants will use to manage their recovery independently). …”

A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation by Tan, Lay Poh, Yu, Ting, Chua, Chee Kai, Tay, Chor Yong, Wen, Feng, Yu, Haiyang, Chan, Jerry Kok Yen, Chong, Mark Seow Khoon, Leong, David Tai Wei

“…Recent work shows that cell shape manipulation via micropatterning can modulate the differentiation of bone-marrow-derived MSCs. Herein, the effect of micropatterning on the myogenesis of MSCs isolated from three different sources (bone marrow, fetal tissue, and adipose) is reported. …”
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Specific inhibition of PI3K p110δ inhibits CSF‐1‐induced macrophage spreading and invasive capacity by Mouchemore, KA, Sampaio, N, Murrey, MW, Stanley, ER, Lannutti, BJ, Pixley, FJ

“…Here we show that pY721‐based signaling is necessary for CSF‐1‐stimulated PtdIns(3,4,5)P production. While primary bone marrow‐derived macrophages and the immortalized bone marrow‐derived macrophage cell line M−/−.WT express all three class IA PI3K isoforms, p110δ predominates in the cell line. …”

Synthesis and application of titanium dioxide nanotube and composites by Liang, Kun

“…Titanium dioxide (TiO2) nanotube has been demonstrated to be one of popular material in many research areas. …”
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My research career by Ma, Xueliang

“…I was born in Rongcheng County in Shandong province on June 22. 1913. …”
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The medium-term results of arthroscopic hip surgery compared with physiotherapy and activity modification for the treatment of femoroacetabular impingement syndrome: a multicentre... by Palmer, A, Fernquest, S, Logishetty, K, Rombach, I, Harin, A, Mansour, R, Dijkstra, P, Andrade, T, Dutton, S, Glyn-Jones, S

Determinants Of Displaced Commercial Risk In Islamic Banking Institutions: Malaysia Evidence by Che Arshad, Noraziah, Zakaria, Roza Hazli, Sulaiman @ Mohamad, Ahmad Azam, Irijanto, Tubagus Thresna

“…DCR arises from the assets managed on behalf of the investment account holders which may be borne by the Islamic bank’s own capital, when the Islamic banks forgo part or all of its share of profits on the investment account holders funds, in order to increase the return to the investment account holders. …”
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Rule Britannia: Brexit and the end of empire by Dorling, D, Tomlinson, S

“…In this wide-ranging and thoughtful analysis, now fully updated to cover the fallout from Brexit and the impact of coronavirus, Dorling and Tomlinson argue that if Britain can reconcile itself to its new place on the world stage, a new identity can be born from the ashes. <i>Rule Britannia</i> is a powerful call to leave behind the jingoistic ignorance of the past and build a fairer Britain, eradicating the inequality that blights our society and embracing our true strengths.…”

SMRT spectrum sensing by Gan, Hui Da

“…This would help prevent train breakdowns which can be very disruptive, especially in Singapore where daily train ridership exceeds 3 million. [1] This information will the be displayed on a webpage which will be updated in real time as train moves along the tracks via a train borne device. The signal spectrum will be captured, analysed and uploaded to an online database for real time access. …”
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Optimising expression and purification of Dengue soluble E protein by Poh, Nina Yong Xin

“…Dengue, a type of flavivirus, is a widespread mosquito-borne infection lacking effective antiviral treatments. …”
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