Effects of dehydrothermal treatment on collagen by Yeo, Sherrill Yan Ling.

“…Collagen is the most fundamental unit of the extra cellular matrix and is found in most mammal tissues such as the tendon, cartilage, bone and skin. Due to its excellent biocompatibility, collagen is often used as a matrix for cell infiltration in many tissue regenerative applications. …”
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Ontogeny of intestinal intratumoural macrophages and their contribution in cancer regulation by Soncin, Irene

“…In contrast to their LP counterparts, the intratumoural F4/80(hi) macrophages are able to self-renew and lose the bone marrow dependency. Since their depletion via CSF1R blockade diminishes the tumour burden, our data underline the potential of these tumour-promoting intestinal macrophages as an attractive target for successful cancer immunotherapies.…”
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Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs by Iskander, D, Psaila, B, Gerrard, G, Chaidos, A, Foong, HE, Harrington, Y, Karnik, LC, Roberts, I, de la Fuente, J, Karadimitris, A

“…By combining flow cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(-)CD36(-) bone marrow cells as EEP giving rise to BFU-E, and Lin(-)CD34(+/-)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(+)CD36(+) cells as LEP giving rise to CFU-E, in a hierarchical fashion. …”

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria by Gargiulo, L, Papaioannou, M, Sica, M, Talini, G, Chaidos, A, Richichi, B, Nikolaev, AV, Nativi, C, Layton, M, de la Fuente, J, Roberts, I, Luzzatto, L, Notaro, R, Karadimitris, A

“…The mechanism of bone marrow failure (BMF) in paroxysmal nocturnal hemoglobinuria (PNH) is not yet known. …”

A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling by Deng, H, Zhang, J, Wang, Y, Joshi, D, Pi, X, De Val, S, Schwartz, MA

“…Here we report that high FSS suppresses Smad1/5 by elevating KLF2, which induces the bone morphogenetic protein (BMP) pathway inhibitor, BMP-binding endothelial regulator (BMPER), thereby de-inhibiting Akt. …”

Determination of mosquitoes species diversity and molecular detection of West Nile virus in wild bird habitats in Perak and Selangor, Malaysia by Jafar Ali, Natasha

“…West Nile virus (WNV) is a zoonotic and emerging arthropod-borne RNA virus from the Flaviviridae family. The virus is maintained in a sylvatic cycle between vectors and reservoirs host, the wild birds. …”
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Cytogenetic and molecular aberrations of multiple myeloma patients : a single-center study in Singapore by Ng, Yit Jun, Tan, Yu Min, See, Karen Hsu Shien, Choo, Natasha Swee Lian, Lim, Sherry Xin Er, Lim, Alvin Soon Tiong, Lim, Tse Hui, Yee, Yenny, Lau, Lai Ching, Tien, Sim Leng, Sathish, Kumar, Tan, Daryl Chen Lung

“…FISH employing standard panel probes and 1p36/1q21 and 6q21/15q22 probes was performed on diagnostic bone marrow samples. Results-Thirty-four cases (75.6%) had karyotypic abnormalities. …”
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Recent advancements in additively manufactured hip implant design using topology optimization technique by Noman, Abdulla All, Mohd Shamil, Shaari, Mehboob, Hassan, Abdul Hadi, Azman

“…The recent advancement of additive manufacturing (AM) offers many benefits for the medical sector, which is revolutionizing modern bone repair surgery for patients, including those with damaged hip joints. …”
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Optimisation of stamp compliance for nanoimprint lithography : an experimental and simulation investigation of deformation of Polydimethylsiloxane (PDMS) and Ultraviolet Curable Po... by Ong, Zongjue

“…This simulation is used to predict the deformation of the mold layer for nano-­‐imprint processes under variable conditions such as: 1) Different loading pressure 2) Different modulus of material 3) Different aspect ratio of structure 4) Bulging behavior with different materials For simulation to be accurate, mechanical properties of the materials are obtained by doing tensile tests on five dog-­‐bone samples of each material to acquire the engineering stress–strain curve. …”
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Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging by Jakobsen, NA, Turkalj, S, Zeng, AGX, Stoilova, B, Metzner, M, Rahmig, S, Nagree, MS, Shah, S, Moore, R, Usukhbayar, B, Angulo Salazar, M, Gafencu, G-A, Kennedy, A, Newman, S, Kendrick, BJL, Taylor, AH, Afinowi-Luitz, R, Gundle, R, Watkins, B, Wheway, K, Beazley, D, Murison, A, Aguilar-Navarro, AG, Flores-Figueroa, E, Dakin, SG, Carr, AJ, Nerlov, C, Dick, JE, Xie, SZ, Vyas, P

“…To gain insight into how CH mutations enable gradual clonal expansion, we used single-cell multi-omics with high-fidelity genotyping on human CH bone marrow (BM) samples. Most of the selective advantage of mutant cells occurs within HSCs. …”

新加坡离散华文作家研究 1945-1980 = a study on Singapore diasporic Chinese writers 1945-1980 by 孫惠敏 Sun, Huey Min

“…Whether they were immigrants or native-born, their writings bore witness to how they had strived to integrate into a multi-racial, multi-cultural society with English as the dominant language, their struggle between their attachment to their ancestral home and their commitment to their new-found home, and their final choice to become Singaporeans. …”
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Rethinking speech sound disorder (SSD) in non-syndromic cleft lip and palate: the importance of recognizing phonological and language difficulties by van Eeden, S, McKean, C, Stringer, H

“…<p><strong>Background</strong></p> Children born with cleft palate ± lip (CP ± L) are at risk of speech sound disorder (SSD). …”

Investigating molecular vulnerabilities in TP53-mutant transformed myeloproliferative neoplasms by Paterson, A

“…To validate the selective requirement of PCBP2 in <em>TP53</em>-mutant LSC, I adopted a human bone marrow organoid model which I showed to outperform liquid culture conditions in supporting the survival and proliferation of <em>TP53</em>-sAML samples. …”

Development of bioactive PCL films using low temperature solvent free method by Lim, Lynette Sihui

“…In conclusion, based on the evaluation of the results, 10% MgCl2 has the potential to be developed as a bone scaffold.…”
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Molecular genetics of Dupuytren’s contracture by Aissvarya, Shankar, Ling, King-Hwa, Arumugam, Manohar, Thilakavathy, Karuppiah

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Mechanism of damnacanthal induced apoptosis in CEM-SS cell line by Gopalsamy, Banulata, Saiful Yazan, Latifah, Abdul Hamid, Hisyam

“…Leukaemia, is cancer of organs that is responsible to produce blood specifically the lymphatic system and bone marrow. Due to the harsh effects of currently used cancer drugs, damnacanthal, an anthraquinone obtained from the roots of Morinda elliptica is tested as a potential anticancer agent. …”
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Fracture energy and mechanical properties of toughened epoxy resin with eggshell powder by Fong, Collin, Sugiman, Sugiman, Chin, Desmond, Ahmad, Hilton

“…The material properties and fracture energy of toughened epoxy with eggshell powder (TEEP) were measured and investigated. Dog-bone specimens were fabricated to investigate the mechanical properties of TEEP (i.e. elastic modulus, Poisson’s ratios and tensile strength) and tested under quasi-static tensile loading. …”
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From Sample to Answer: Innovations in sample processing and CRISPR-based diagnostics for enhanced clinical translation and field deployment by Arizti Sanz, Jon

“…We also designed and tested multiplexed diagnostic assays for the detection and differentiation of three tick-borne pathogens in clinical samples. Finally, given the inadequacy of existing sample processing methods – and their importance to nucleic acid test deployment – we developed a high throughput experimental workflow to analyze the effects of chemical reagents on diagnostic assay performance and nuclease activity in patient samples using a commercially available microfluidic platform. …”
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Conditional knock out of N-WASP in keratinocytes causes skin barrier defects and atopic dermatitis-like inflammation by Kalailingam, Pazhanichamy, Tan, Hui Bing, Jain, Neeraj, Sng, Ming Keat, Chan, Jeremy Soon Kiat, Tan, Nguan Soon, Thanabalu, Thirumaran

“…N-WASPK14KO (N-WASP fl/fl ; CK14-Cre) mice were born following Mendelian genetics suggesting that N-WASP expression in keratinocytes is not essential during embryogenesis. …”
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Telomere biology disorders by Kam, Michelle L. W., Nguyen, Trang T. T., Ngeow, Joanne Yuen Yie

“…Telomeres are DNA-protein structures at chromosome ends that maintain chromosome stability; their length affects cell replicative potential and senescence. A constellation of bone marrow failure, pulmonary fibrosis, liver cirrhosis and premature greying is suggestive, however incomplete penetrance results in highly variable manifestations, with idiopathic pulmonary fibrosis as the most common presentation. …”
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