Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…Combining a JAK2 inhibitor with an interferon may be synergistic, as haematopoietic cells are activated from quiescence (a typical kinase resistance mechanism) rendering them more sensitive to inhibition. Ropeginterferon alfa-2b is a next generation pegylated interferon-α-2b with high tolerability and clinical activity in patients with MF, however, evidence of tolerability and activity in combination with fedratinib is lacking in this setting. …”

Data-driven brain emotional learning-based intelligent controller-PID control of MIMO systems based on a modified safe experimentation dynamics algorithm by Shahrizal, Saat, Mohd Ashraf, Ahmad, Mohd Riduwan, Ghazali

“…Furthermore, the low computational burden of MSEDA rendered it a strong alternative to heuristic multi-agent algorithms, which frequently encounter high computational costs with large controller design parameters.…”
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1 by Stubna, Michael William

“…The subsequent polyubiquitination and proteolysis of AGO liberates the miRNA, rendering it vulnerable to nucleases. TDMD underlies the instability of many miRNAs in diverse cell lines and animals. …”
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Between moral responsibility and postmodern disbelief : 'postmodern ethics' in the dramatic works of harold pinter by Fernandez, Stephen Frederick

“…While the actions of the characters in Pinter’s drama may be influenced by the principles of a fixed religious or secular ethical code (for example, the moral law in both its Judeo-Christian and secular renderings), such an influence, I would argue, is external to the relationships between the characters, as the motivation behind their actions is directly dependent upon the quality of their interaction with one another within a particular situation. …”
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Fatigue analysis of steel catenary risers at the touchdown point by Feng, Zi Li

“…It is found that LF motions can render the trench profile broader and shallower. LF motions are beneficial as they can shift the location of the TDP, thus spreading the damage along the riser. …”
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Translational GTPase BipA is involved in the maturation of a large subunit of bacterial ribosome at suboptimal temperature by Goh, Kwok Jian, Ero, Rya, Yan, Xin-Fu, Park, Jung Eun, Kundukad, Binu, Zheng, Jun, Sze, Siu Kwan, Gao, Yong-Gui

“…Based on the growth curve, soft agar swimming assay, and sucrose gradient sedimentation analysis, mutation of the catalytic residue His78 rendered plasmid-borne bipA unable to complement its deletion phenotypes. …”
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Generative pretrained autoregressive transformer graph neural network applied to the analysis and discovery of novel proteins by Buehler, Markus J

“…Further trained on inverse tasks, the model is rendered capable of designing proteins with these properties as target features. …”
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Beyond Color: Lattice Gauge Theory for Strongly-Coupled Physics by Oare, Patrick R.

“…This computational formalism computes observables by discretizing spacetime to render the path integral tractable. The primary focus of LGT in the 40 years since its inception has been the study of QCD, as the theory has direct physical relevance to so much of our universe, and the desire to understand QCD has driven many conceptual breakthroughs and advancements in LGT. …”
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Wideband low noise amplifiers employing noise cancelling technique by Yu, Haohong

“…Nevertheless, this LNA shows a mediocre IIP3 of -4.5 dBm, rendering the circuit vulnerable to intermodulation interference. …”
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Speeding up deep neural network training with decoupled and analytic learning by Zhuang, Huiping

“…These lockings impose strong synchronism among modules (a consecutive stack of layers), rendering most modules idle during training. A fully decoupled learning method using delayed gradients (FDG) is first proposed which addresses all the three lockings. …”
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Understanding lay conceptions of workplace criers: a prototype analysis by Tan, Terri Su-May

“…Despite this, prior assessments of such conceptions have been limited to several crier features pre-selected by scholars (e.g., warmth, competence), rendering observers’ range of conceptions largely unexamined. …”
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Carbene-based bioadhesive blended with amine, thiol, and acrylate liquid additives by Ellis, Elizabeth, Djordjevic, Ivan, Muhammad Naziruddin Bin Mohd Ali, Steele, Terry W. J.

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Application and control for virtual synchronous generators by Guo, Yian

“…VSGs, particularly their ability to offer essential frequency and voltage support, render them suitable for a wide array of applications. …”
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Ammonia-dependent reducing power redistribution for purple phototrophic bacteria culture-based biohydrogen production by Huang, Peitian, Chen, Yun, Li, Zong, Zhang, Baorui, Yu, Siwei, Zhou, Yan

“…The results show that (a) The absence of ammonia resulted in the best performance for hydrogen production, with 44 % of the reducing power distributed to H2 and the highest H2 volumetric productivity, while the allocation of reducing power to hydrogen production stopped when ammonia loading was above 7.6 mg NH4-N·L-1·d-1; (b) when PPB required to eliminate reducing power under ammonia limited conditions, PHA production was the preferred pathway followed by the hydrogen production pathway, but once PHA accumulation reached saturation, hydrogen generation pathway dominated; (c) under ammonia limited conditions, the TCA cycle was more activated rendering higher NADH (i.e. reducing power) production compared with that under ammonia sufficient conditions which was verified by metagenomics analysis, and all the hydrogen production, PHA accumulation and carbon fixation pathways were highly active to dissipate reducing power. …”
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Photonic analog-to-digital conversion and photonic microwave signal generation by Wong, Jia haur

“…It should be emphasized that all the techniques demonstrated in this thesis make use of mode-locked lasers, thus rendering it a common component between the two topics studied here. …”
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Tri-layer tissue engineering heart valve based on collagen, elastin and hyaluronic acid by Ma, Z

“…</p> <br> <p>Despite the lowering effect on mechanical properties, hydration eliminated the mechanical strength difference between the two designs, rendering them both promising candidates for future <em>in vitro</em> and <em>in vivo</em> studies. …”

Cryogelation of human hair keratins by Chua, Huei Min

“…Microarchitecture analysis revealed that FT cycling rendered a change from sheet-like lamellae in FT0 sponges to interconnected polygonal pores in freeze-thawed sponges. …”
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Structural and functional studies of C-nucleoside formation enzymes by Li, W

“…The substitution of C-C glycosidic bonds holds the promise of preserving the drug properties of the parent compound while rendering the compound essentially undegradable.</p> <br> <p>The thesis overviews the history of natural product discovery, tracing its evolution from ancient folk traditions to the contemporary application of advanced genetics and chemical modifications for biosynthesis. …”

Early detection of reduced artemisinin susceptibility in plasmodium falciparum using novel phenotypic indicators by Xiong, Aoli

“…An index ΔΔA-ratio was defined and shown to be capable of distinguishing well characterized resistant and sensitive lab strains and one clinical isolate. However, it rendered suboptimal detection accuracy when applied to a wider range of clinical isolates. …”
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Analysis of lava flow impacts for use in risk assessments by Meredith, Elinor Siwan

“…Some volcanic hazards leave little deposit but can kill everyone in their path, while others move slowly enough to avoid causing fatalities but leave thick solidified deposits that can render land unusable for decades. This thesis is concerned with improving our knowledge of damage to the built environment associated with the latter, lava flows. …”
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