Luteolin escape mutants of dengue virus map to prM and NS2B and reveal viral plasticity during maturation by Vasudevan, Subhash G., Peng, Minhua, Swarbrick, Crystall Marie Dawn, Chan, Kitti Wing-Ki, Luo, Dahai, Zhang, Wei, Lai, Xiaoping, Li, Geng

“…Our findings suggest that luteolin inhibition of furin may occur at host/pathogen interface that permits the virus to escape the suppression by mutating key residue that may lead to an altered interface.…”
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Maternal infections during pregnancy and the risk of childhood leukaemia in the offspring: Evidence from large-scale cohort studies by He, J

“…Maternal infection during pregnancy might lead to chromosomal or immunological alterations in the fetus and could be a risk factor for childhood leukaemia. …”

Category learning in infants and adults by Sucevic, J

“…By comparing neural signatures of visual object processing at the very beginning of the category learning process and after an extensive categorisation practice, I tested how categorisation experience alters the way in which exemplars are processed. The results revealed that categorisation experience is linked to a modulation of several event-related potentials components suggesting that categorisation may affect visual object processing at an early stage.…”

Conserving goat sperm post-thawed gene expression and cellular characteristics using the antioxidant coenzyme Q10 supplementation by Oktanella, Yudit, Mustofa, Imam, An-Haru, Fahrunnisak Al-Firda Razak, Putri, Desinta Dwi Melati, Hendrawan, Viski Fitri, Susilowati, Suherni, Degu, Nurhusien Yimer, Hernawati, Tatik

“…Despite strong post-thaw motility and no visible DNA fragmentation, sperm can still exhibit altered gene expression patterns. To reduce the damaging impact of free radicals during cryopreservation, antioxidants are typically added to the freezing medium. …”
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Identification of proteins and genes as potential biomarkers in brown-marbled grouper (Epinephelus fuscoguttatus forsskal) resistance to Vibrio sp by Low, Chen Fei

“…In summary, resistance of grouper to bacterial infection involved complex mechanisms consisting of different pathways with distinct methods of activation and regulation. Genes and proteins altered in these pathways are potential markers to identify Vibrio resistant grouper as well as targets for immunomodulation and disease prevention through vaccination. …”
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Optimization, encapsulation and characterization of bromelain-generated angiotensin I-converting enzyme (Ace) - inhibitory hydrolysates from stone fish (Actinopyga lecanora Jaeger) by Auwal, Shehu Muhammad

“…Serum biochemical analysis and histomorphological examination following 28 days of repeated exposure of the rats to the 200 mg/kg, 400 mg/kg and 800 mg/kg doses of the nanoparticles, revealed no alteration in the function and architecture of both liver and kidney with no occurrence of cellular necrosis. …”
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Patient and Health Care Worker Perceptions of Communication and Ability to Identify Emotion When Wearing Standard and Transparent Masks by Chu, Jacqueline N., Collins, Joy E., Chen, Tina T., Chai, Peter R., Dadabhoy, Farah, Byrne, James D., Wentworth, Adam, DeAndrea-Lazarus, Ian A., Moreland, Christopher J., Wilson, Jaime A. B., Booth, Alicia, Ghenand, Omkar, Hur, Chin, Traverso, Giovanni

“…IMPORTANCE: Adoption of mask wearing in response to the COVID-19 pandemic alters daily communication. OBJECTIVE: To assess communication barriers associated with mask wearing in patient-clinician interactions and individuals who are deaf and hard of hearing. …”
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Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…In the first part, I have characterized a panel of human lung cancer cell lines harboring genetic gain-of-function alterations of clinically actionable tyrosine kinases (TKs). …”
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Tracing RNA biography: in situ transcriptome profiling by novel spatial omics technologies by Ren, Jingyi (Rena)

“…In primary skin samples, we noted cell-type-dependent alterations in the rates of RNA synthesis, transport, and degradation. …”
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Habit Formation and Political Persuasion: A Behavioral and Statistical Approach by Tohidi Kalorazi, Amir

“…By leveraging store closures as a disruptive event, we examine how these closures prompt individuals to alter their purchasing patterns. We propose that such disruptions encourage people to engage in more deliberate decision-making processes, leading them to explore alternatives that they might have previously overlooked due to established habits. …”
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Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation by Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano

“…The CSF sTNF-R1-associated pattern (encompassing high levels of CXCL13, TWEAK, LIGHT, IL-35, osteopontin, pentraxin-3, sCD163 and chitinase-3-L1) was mainly related to altered T cell and B cell signalling. Finally, the CSF TNFR2-associated pattern (encompassing high CSF levels of IFN-β, IFN-λ2, sIL-6Rα) was linked to Th cell differentiation and regulatory cytokine signalling. …”
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Natural robustness of machine learning in the open world by Wei, Hongxin

“…This motivates the need to preserve model performance under naturally induced data corruptions or alterations across the machine learning pipeline, which is termed ``Natural Robustness". …”
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Neuronal control of cardiac excitability in pro-hypertensive states by Larsen, H

“…This cross talk is significantly altered in the pro-hypertensive state, via the differential involvement of PDEs. …”

Developing optogenetics for use in vascular research by Rorsman, N

“…The light intensity range that enables optical control of arterial tone primarily through the recruitment of endogenous channels and without substantial alteration of intracellular pH, was identified. Within this range, mice expressing ChR2(H134R) in SMCs are a powerful experimental model for achieving accurate and tuneable optical voltage-clamp of SMCs and finely-graded control of arterial tone, offering new avenues to the discovery of vasorelaxing drugs.…”

Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection by Alabaf, S

“…Some lead to postsynaptic acetylcholine receptor (AChR) deficiency or altered receptor kinetic properties and in a group of patients with CMS, the mutations impair clustering of AChRs. …”

Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…</p> <p>To gain a deeper understanding of the action mechanism underlying PAK1 small molecule activators, fluorescence resonance energy transfer (FRET), superresolution single molecular imaging, and mass photometry were applied to illustrate the conformational changes and alterations in PAK1 dimerization upon the binding of small molecule activators. …”

Quantifying the energy consumption of the water use cycle by Cardenes Trujillo, I

“…The results also show that incorporating detailed energy information into long-term water resources planning can alter the choices made in water supply options, by providing more complete information. …”

Characterisation of red palm oil microcapsule with solution-enhanced dispersion by supercritical carbon dioxide technology by Lee, Wan Jun

“…The fatty acid composition, chemical structures and thermal properties of the oil were not altered by the SEDS process. The thermal stability, oxidative stability and retention of carotenes and vE of RPO were improved after SEDS encapsulation. …”
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Interaction of TiO2 and ZnO NPs with human skin cells by Gautam, Archana

“…Concerns over their increased penetration across the skin in cases of the compromised or altered skin barrier and the consequent physiological influences are real. …”
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Evidence for cross-protection against subsequent febrile respiratory illness episodes from prior infections by different viruses among Singapore military recruits 2009-2014 by Chen, Mark I-Cheng, Loh, Jin Phang, Chuah, Cheryl X. P., Gao, Christine Qiu Han, Sun, Yinxiaohe, Ng, Sock Hoon, Koh, Victor Wee-Hong, Goh, Ee Hui, Zhao, Xiahong, Tambyah, Paul Anantharajah, Cook, Alex R., Chng, Jeremiah, Pang, Junxiong, Tan, Boon Huan, Lee, Vernon J.

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