Social relationships and its effects on cognitive decline and MCI: a review by Goh, Sarah Si Ern, Poh, Nichelle Siting

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Pan-European atmospheric lead pollution, enhanced blood lead levels, and cognitive decline from Roman-era mining and smelting by McConnell, JR, Chellman, N, Plach, A, Wensman, SM, Plunkett, G, Stohl, A, Smith, N, Vinther, BM, Dahl-Jensen, D, Steffensen, JP, Fritzsche, D, Brugger, SO, McDonald, BT, Wilson, AI

“…Based on modern epidemiological studies, this air pollution enhanced childhood blood lead levels (BLLs) by about 2.4 µg/dl leading to widespread cognitive decline including an estimated 2.5-to-3 point reduction in intelligence quotient.…”

Independent writing tasks vs. integrated writing tasks: the cognitive demands and their impacts on linguistic complexity in EFL writing by Zhao, Ziming, Nimehchisalem, Vahid, Chan, Mei Yuit

“…Despite many studies investigating the effects of task complexity on L2 writing performance, little attention has been given to the specific effects of independent vs. integrated writing tasks and their cognitive demands on EFL learners. This study aimed to address this gap by conducting a comprehensive examination of the cognitive demands exerted by these two types of writing tasks and their effects on linguistic complexity outcomes among 35 Chinese EFL learners. …”
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Performance and validation of a digital memory test across the Alzheimer’s disease continuum by Toniolo, S, Attaallah, B, Maio, MR, Tabi, YA, Slavkova, E, Klar, VS, Saleh, Y, Idris, MI, Turner, V, Preul, C, Srowig, A, Butler, C, Thompson, S, Manohar, SG, Finke, K, Husain, M

“…Memory imprecision was able to predict cognitive decline on standard cognitive tests over one year. …”

Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model by Emmerson, JT, Do Carmo, S, Lavagna, A, Huang, C, Wong, TP, Martinez-Trujillo, JC, Cuello, AC

“…Extensive behavioral testing for learning and memory was also conducted to evaluate cognitive decline. Additionally, we investigated brain inflammation, neuronal cell loss, as well as synaptic plasticity through acute brain slice electrophysiological recordings and Western blotting. …”

Profiling heterogeneity of Alzheimer's disease using white-matter impairment factors by Sui, Xiuchao, Rajapakse, Jagath Chandana

“…MRI studies have revealed that heterogeneous gray matter atrophy patterns are associated with specific traits of cognitive decline. Although white matter (WM) impairment also contributes to AD pathology, its heterogeneity remains unclear. …”
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How balanced are you? Bilingualism and the development of attentional control in English-Mandarin preschool children by Chan, Clara Gek Hoon

“…As part of the theory, they highlight the importance of context; three different bilingual conversational contexts were identified, and differing cognitive demands were attributed to those three contexts. …”
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A function-based mapping of sensory integration along the cortical hierarchy by Wei, W, Benn, RA, Scholz, R, Shevchenko, V, Klatzmann, U, Alberti, F, Chiou, R, Wassermann, D, Vanderwal, T, Smallwood, J, Margulies, DS

“…This dimension identifies differences between brain states and emphasizes how sensory integration changes flexibly in response to varying cognitive demands. Furthermore, meta-analytic functional decoding with our model highlights the close relationship between cognitive functions and sensory integration, showing its potential for future research of human cognition through sensory information processing.…”

Alzheimer’s Amyloid Hypothesis and Antibody Therapy: Melting Glaciers? by Høilund-Carlsen, Poul F., Alavi, Abass, Castellani, Rudolph J., Neve, Rachael L., Perry, George, Revheim, Mona-Elisabeth, Barrio, Jorge R.

“…Lecanemab and donanemab are also thought to cause some statistical delay in the determination of cognitive decline. However, clinical efficacy that is less than with conventional treatment, selection of amyloid-positive trial patients with non-specific amyloid-PET imaging, and uncertain therapy-induced removal of cerebral amyloids in clinical trials cast doubt on this anti-Alzheimer’s antibody therapy and hence on the amyloid hypothesis, calling for a more thorough investigation of the negative impact of this type of therapy on the brain.…”
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Cognitive training and mild cognitive impairment : a review by Chua, Xavier Cheng En, Seow, Jonathan Wei En, Tan, Huiting

“…Mild cognitive impairment (MCI) is largely viewed as a pre-clinical stage in the trajectory of Alzheimer’s disease (AD) where the extent of cognitive decline is relatively mild, thus allowing for the application of earlier, more effective treatment. …”
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Association between cognition and gene polymorphisms involved in thrombosis and haemostasis by Quinn, TJ, Alghamdi, J, Padmanabhan, S, Porteous, DJ, Smith, BH, Hocking, L, Deary, IJ, Gallacher, J, Messow, M, Stott, DJ

“…An association between blood markers of thrombosis and haemostasis and cognitive decline has been described. These results may be confounded by lifestyle and environmental factors. …”

Data for iTRAQ profiling of micro-vesicular plasma specimens : in search of potential prognostic circulatory biomarkers for Lacunar infarction by Datta, Arnab, Sze, Siu Kwan

“…To discover potential prognostic biomarkers of Lacunar infarction (LACI), here we present quantitative proteomics data of plasma microvesicle-enriched fraction derived by comparative isobaric profiling of three groups of prospectively followed-up LACI patients (LACI – no adverse outcome, LACI –recurrent vascular event and LACI – cognitive decline) and a demographically matched control group. …”
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Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia by Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

“…<p><b>Conclusions</b></p> Plasma choline, as opposed to TMAO, was found to be associated with cognitive decline, brain atrophy, and markers of cerebral small vessel disease. …”

Relationship between selected biopsychosocial factors on cognitive functions among Malaysian community-dwelling older adults by Foong, Hui Foh

“…The original purpose of this study was to prospectively examine the degree of cognitive decline and its associated risk factors. However, only baseline data from the first wave of data collection were used in this study. …”
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Mixed tree nuts, cognition and gut microbiota: a 4-week, placebo-controlled, randomized crossover trial in healthy non-elderly adults by Haskell-Ramsay, Crystal, Dodd, Fiona L., Smith, Darren, Cuthbertson, Lewis, Nelson, Andrew, Lodge, John K., Jackson, Philippa A.

“…The effects appear to be independent of one another, but further exploration is required in those experiencing cognitive decline and/or gut dysbiosis. The study was registered at clinicaltrials.gov (identifier: NCT03500601).…”
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Cognitive enhancement in video game training: two separate routes of transfer? by Oei, Chie Ming

“…In study 1, different video games with different cognitive demands were compared. Following 20 hours of training on one of several games, participants’ improvement on various cognitive tasks matched the demands of the game that they trained in respectively. …”
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Fiona Patrick - Thesis submitted in partial fulfilment of the degree of Doctor of Clinical Psychology (DClinPsych) by Patrick, F

“…</p> <br> <p><strong>SIP</strong> </p><p>Dementia is a neurodegenerative disease characterised by cognitive decline. Alzheimer’s disease (a dementia subtype) affects around 88% of people with Down’s Syndrome (DS) by the age of 65. …”

Filipino multicomponent intervention to maintain cognitive performance in high-risk population (FINOMAIN): study protocol for a cluster randomized controlled trial by Dominguez, Jacqueline, De Guzman, Ma Fe, Chen, Annabel Shen-Hsing, Sano, Mary, Waldemar, Gunhild, Phung, Thien Kieu Thi

“…Background: More than half of the people with dementia live in lower-middle income countries (LMIC), yet we lack research and evidence-based knowledge to guide health promotion and prevention strategies for cognitive decline. In the Philippines, the prevalence of mild cognitive impairment (MCI) and cardiovascular risk factors among older persons are high, making this population at high risk for developing dementia. …”
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Chronic neuropsychiatric sequelae of SARS-CoV-2: protocol and methods from the Alzheimer's Association Global Consortium by de Erausquin, GA, Snyder, H, Brugha, TS, Newton, C

“…<br><br> <strong>Key Points</strong><br> &#x2022 The following review describes what is known so far in terms of molecular and epidemiological links among COVID-19, the brain, neurological symptoms, and AD and related dementias (ADRD)<br><br> &#x2022 The primary objective of this large-scale collaboration is to clarify the pathogenesis of ADRD and to advance our understanding of the impact of a neurotropic virus on the long-term risk of cognitive decline and other CNS sequelae. No available evidence supports the notion that cognitive impairment after SARS-CoV-2 infection is a form of dementia (ADRD or otherwise). …”

Characterizing Cortex-Hippocampus Interactions During Language Processing by Lee, Jiachen Elizabeth

“…We then characterize its response profile and show that it is responsive to semantically meaningful material but is not engaged during cognitively demanding spatial working memory and arithmetic tasks. …”
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