Targeting the Bromodomain-containing protein 4 in ovarian clear cell carcinoma by Wong, Erica Shiyi

“…Ovarian clear cell carcinoma (OCCC) is the second most common histopathological subtype of ovarian carcinoma (OC), making up 5-25% of all OC. …”
Get full text

First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

Using Sequenom to identify KRAS mutations in an Asian cohort of ovarian mucinous cancer by Tiong, Wen Ning

“…While there are distinct differences between mucinous epithelial ovarian cancer (mEOC) and the other subtypes of EOC, a standard treatment regimen is followed for all EOC histotypes. …”
Get full text

The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Pounds, R, Croft, W, Pearce, H, Hossain, T, Singh, K, Balega, J, Jeevan, DN, Sundar, S, Kehoe, S, Yap, J, Moss, P, Zuo, J

“…Introduction: Ovarian cancer (OC) is the sixth most common malignancy in women and the poor 5-year survival emphasises the need for novel therapies. …”

In vitro evaluation of oral contraceptives on long-tailed macaque (Macaca fascicularis) primary ovarian cells by Muhammed, Mikail, Tengku Azizan, Tengku Rinalfi Putra, Mohd Noor, Mohd Hezmee, Abu Hassim, Hasliza, Che'Amat, Azlan, Saleh, Annas Bin, Han, Mark Hiew Wen, Ab Latip, Mohd Qayyum

“…The present study aims to investigate the effect of oral contraceptives (Nordette, Noriday, and Ella) on long-tailed macaque ovarian cells. We determine the cell viability and cytotoxicity as well as the morphological changes of the drugs on long-tailed macaque ovarian cells using the MTT assay, Acridine orange/propidium iodide double staining method, morphological examination, and the 4, 6-diamidino-2-phenylindole (DAPI) staining method. …”
Get full text

Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer by Mishra, Alok K., Ye, Tianyi, Banday, Shahid, Thakare, Ritesh P., Su, Chinh Tran-To, Pham, Ngoc N. H., Ali, Amjad, Kulshreshtha, Ankur, Chowdhury, Shreya Roy, Simone, Tessa M., Hu, Kai, Zhu, Lihua Julie, Eisenhaber, Birgit, Deibler, Sara K., Simin, Karl, Thompson, Paul R., Kelliher, Michelle A., Eisenhaber, Frank, Malonia, Sunil K., Green, Michael R.

“…CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a "don't eat me" signal that prevents targeting and phagocytosis by macrophages. …”
Get full text

ranscriptome profile and gene expression during different ovarian maturation stages of Macrobrachium rosenbergii (De Man, 1879) by Mardhiyyah, Mohd Pauzi, Zakaria, Muhammad Faiz, Amin-Safwan, Adnan, Nur-Syahirah, Mamat, Sung, Yeong Yik, Ma, Hongyu, Ikhwanuddin, Mhd

“…The differentially expressed genes (DEG) analysis conducted in this study led to identifying cyclin B, insulin receptor (IR), oestrogen sulfotransferase (ESULT) and vitellogenin (Vg), which are critical in ovarian maturation. Nevertheless, some M. rosenbergii ovarian maturation-related genes, such as small ubiquitin-like modifier (SUMO)-activating enzyme subunit 1, E3 ubiquitin-protein ligase RNF25, and neuroparsin, were first identified in this study. …”
Get full text

Multiple signatures of a disease in potential biomarker space : getting the signatures consensus and identification of novel biomarkers by Ow, Ghim Siong, Kuznetsov, Vladimir Andreevich

Subjects: Get full text
Get full text

Effect of elevated temperatures on tensile properties of concrete by Alireza Javadian

Get full text

Barriers to women's career advancement in Pakistan: Insights from women in senior management roles by Khalid, Javaria, Othman, Nooraini

Get full text

Development of an extrudable paste to build mycelium-bound composites by Soh, Eugene, Chew, Zhi Yong, Saeidi, Nazanin, Javadian, Alireza, Hebel, Dirk, Le Ferrand, Hortense

Get full text

Investigation of the effects of Anti-Müllerian Hormone on preventing Doxorubicin-induced primordial follicle loss by Wei, X

“…<p>Survival rates from childhood cancer are improving, however chemotherapy can cause ovarian failure and infertility. Doxorubicin (DXR) is a gonadotoxic chemotherapy agent commonly used in childhood cancers. …”

Ethical issues surrounding access to care for BRCA mutations by Huang, C

“…<p>Harmful BRCA (breast cancer susceptibility genes 1 and 2) mutations greatly increase women's risks of breast and/or ovarian cancer but are found in less than 1 per cent of the general population. …”

A new blood fluke,Parasanguinicola vastispina gen. nov., sp. nov. (Trematoda: Sanguinicolidae), from sea bass Lates calcarifer (Centropomidae) cultured in Malaysia by Herbert, B.W., Shaharom, F.M.

“…It is distinguished by its massive armature and widely spaced genital pores, the female pore being pre-ovarian. P. vastispina inhabits the branchial arteries, dorsal aorta, mesenteric venules and renal artery of its host. …”
Get full text

Specialized replication mechanisms maintain genome stability at human centromeres by Scelfo, A, Angrisani, A, Grillo, M, Barnes, BM, Muyas, F, Sauer, CM, Leung, CWB, Dumont, M, Grison, M, Mazaud, D, Garnier, M, Guintini, L, Nelson, L, Esashi, F, Cortés-Ciriano, I, Taylor, SS, Déjardin, J, Wilhelm, T, Fachinetti, D

“…Prolonged stress causes centromeric alterations like ruptures and translocations, as observed in ovarian cancer models experiencing replication stress. …”

Inferring structural variant cancer cell fraction by Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM, Papenfuss, T, Hovens, CM, Markowetz, F, Macintyre, G, PCAWG Consortium

“…As part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) consortium, which aggregated whole-genome sequencing data from 2658 cancers across 38 tumour types, we use SVclone to reveal a subset of liver, ovarian and pancreatic cancers with subclonally enriched copy-number neutral rearrangements that show decreased overall survival. …”

Lung cancer AI-based diagnosis through multi-modal integration of clinical and imaging data by Ulag, AS, Gonzales, RA

“…National Institute of Health’s (NIH) Prostate, Lung, Colorectal, and Ovarian (PLCO) dataset, which includes over 100,000 chest X-rays and associated clinical records, we preprocessed and balanced the data to train and test our models. …”

Investigating follicle development using in vitro technologies by Lo, B

“…<p>Patients with dysfunctional ovaries, such as those with premature ovarian insufficiency and granulosa cell tumours, do not have normal follicle development and may not respond to traditional assisted reproductive techniques. …”

Big data and computational biology strategy for personalized prognosis by Ow, Ghim Siong, Tang, Zhiqun, Kuznetsov, Vladimir A.

“…Our analyses revealed that Euclidean distance rather correlation distance measure was effective in defining an unbiased similarity measure calculated between two PSVs.We implemented our methods to high-grade serous ovarian cancer (HGSC) based on a 36-mRNA predictor that was previously shown to stratify patients into 3 distinct prognostic subgroups. …”
Get full text
Get full text

Functional analysis of germline RAD51C missense variants highlight the role of RAD51C in replication fork protection by Kolinjivadi, Arun Mouli, Chong, Siao Ting, Choudhary, Ramveer, Sankar, Haresh, Chew, Ee Ling, Yeo, Claresta, Chan, Sock Hoai, Ngeow, Joanne

“…We identified novel RAD51C variants of uncertain significance (VUS) from breast, ovarian, pancreatic, and gastric cancer patients and functionally characterized the effect of these variants in replication fork protection and double-strand breaks (DSB's) repair. …”
Get full text