Targeting the Bromodomain-containing protein 4 in ovarian clear cell carcinoma by Wong, Erica Shiyi

“…Ovarian clear cell carcinoma (OCCC) is the second most common histopathological subtype of ovarian carcinoma (OC), making up 5-25% of all OC. …”
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First-line chemotherapy for advanced ovarian cancer: paclitaxel, cisplatin and the evidence by Sandercock, J, Parmar, MKB, Torri, V

Neutron contamination of Varian Clinac iX 10 MV photon beam using Monte Carlo simulation by Yani, S., Tursinah, R., Rhani, M. F., Soh, Roger Cai Xiang, Haryanto, F., Arif, I.

“…This study concerns the simulation of neutron contamination emitted from Varian Clinac iX 10 MV using Monte Carlo code system. …”
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Using Sequenom to identify KRAS mutations in an Asian cohort of ovarian mucinous cancer by Tiong, Wen Ning

“…While there are distinct differences between mucinous epithelial ovarian cancer (mEOC) and the other subtypes of EOC, a standard treatment regimen is followed for all EOC histotypes. …”
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The emergence of DNAM-1 as the facilitator of NK cell-mediated killing in ovarian cancer by Pounds, R, Croft, W, Pearce, H, Hossain, T, Singh, K, Balega, J, Jeevan, DN, Sundar, S, Kehoe, S, Yap, J, Moss, P, Zuo, J

“…Introduction: Ovarian cancer (OC) is the sixth most common malignancy in women and the poor 5-year survival emphasises the need for novel therapies. …”

Inferring structural variant cancer cell fraction by Cmero, M, Yuan, K, Ong, CS, Schröder, J, PCAWG Evolution and Heterogeneity Working Group, Corcoran, NM, Papenfuss, T, Hovens, CM, Markowetz, F, Macintyre, G, PCAWG Consortium

“…We present SVclone, a computational method for inferring the cancer cell fraction of structural variant (SV) breakpoints from whole-genome sequencing data. …”

In vitro evaluation of oral contraceptives on long-tailed macaque (Macaca fascicularis) primary ovarian cells by Muhammed, Mikail, Tengku Azizan, Tengku Rinalfi Putra, Mohd Noor, Mohd Hezmee, Abu Hassim, Hasliza, Che'Amat, Azlan, Saleh, Annas Bin, Han, Mark Hiew Wen, Ab Latip, Mohd Qayyum

“…The present study aims to investigate the effect of oral contraceptives (Nordette, Noriday, and Ella) on long-tailed macaque ovarian cells. We determine the cell viability and cytotoxicity as well as the morphological changes of the drugs on long-tailed macaque ovarian cells using the MTT assay, Acridine orange/propidium iodide double staining method, morphological examination, and the 4, 6-diamidino-2-phenylindole (DAPI) staining method. …”
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Targeting the GPI transamidase subunit GPAA1 abrogates the CD24 immune checkpoint in ovarian cancer by Mishra, Alok K., Ye, Tianyi, Banday, Shahid, Thakare, Ritesh P., Su, Chinh Tran-To, Pham, Ngoc N. H., Ali, Amjad, Kulshreshtha, Ankur, Chowdhury, Shreya Roy, Simone, Tessa M., Hu, Kai, Zhu, Lihua Julie, Eisenhaber, Birgit, Deibler, Sara K., Simin, Karl, Thompson, Paul R., Kelliher, Michelle A., Eisenhaber, Frank, Malonia, Sunil K., Green, Michael R.

“…CD24 is frequently overexpressed in ovarian cancer and promotes immune evasion by interacting with its receptor Siglec10, present on tumor-associated macrophages, providing a "don't eat me" signal that prevents targeting and phagocytosis by macrophages. …”
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Marine predator algorithm and related variants: A systematic review by Philibus, Emmanuel, Azlan, Mohd Zain, Prasetya, Didik Dwi, Mahadi, Bahari, Norfadzlan, Yusup, Rozita, Abdul Jalil, Mazlina, Abdul Majid, Azurah, Abu Samah

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Fast and accurate variant identification tool for sequencing-based studies by Gaston, Jeffry M., Alm, Eric J., Zhang, An-Ni

“…Results We present QuickVariants, a bioinformatics tool that effectively summarizes variant information from read alignments and identifies variants. …”
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ranscriptome profile and gene expression during different ovarian maturation stages of Macrobrachium rosenbergii (De Man, 1879) by Mardhiyyah, Mohd Pauzi, Zakaria, Muhammad Faiz, Amin-Safwan, Adnan, Nur-Syahirah, Mamat, Sung, Yeong Yik, Ma, Hongyu, Ikhwanuddin, Mhd

“…The differentially expressed genes (DEG) analysis conducted in this study led to identifying cyclin B, insulin receptor (IR), oestrogen sulfotransferase (ESULT) and vitellogenin (Vg), which are critical in ovarian maturation. Nevertheless, some M. rosenbergii ovarian maturation-related genes, such as small ubiquitin-like modifier (SUMO)-activating enzyme subunit 1, E3 ubiquitin-protein ligase RNF25, and neuroparsin, were first identified in this study. …”
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Functional characterisation guides classification of novel BAP1 germline variants by Hong, Jing Han, Chong, Siao Ting, Lee, Po-Hsien, Tan, Jing, Heng, Hong Lee, Nur Diana Ishak, Chan, Sock Hoai, Teh, Bin Tean, Ngeow, Joanne

“…In this study, we functionally characterise known BAP1 pathogenic and likely benign germline variants out of these six patients to aid in the evaluation and classification of unknown BAP1 germline variants. …”
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Analysis and development of parametric model and design variants of composite vehicle structure by Saifullakhan Amjad Khan

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Double trouble: Predicting new variant counts across two heterogeneous populations by Shen, Yunyi

“…We provide the first predictor for the number of new shared variants and new total variants that can handle heterogeneity in multiple populations. …”
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Molecular and biochemical characterisation of human casein kinase I alpha splice variants by Yong, Thomas Joon Kin.

“…It has been shown in mammalian tissues that CKI alpha exists in two or three alternatively spliced variants (Rowles et al., 1991; Zhang et al., 1996; Kuret et al., 1997). …”
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Emergence and spread of two SARS-CoV-2 variants of interest in Nigeria by Olawoye, IB, Oluniyi, PE, Oguzie, JU, Uwanibe, JN, Kayode, TA, Olumade, TJ, Ajogbasile, FV, Parker, E, Eromon, PE, Abechi, P, Sobajo, TA, Ugwu, CA, George, UE, Ayoade, F, Akano, K, Oyejide, NE, Nosamiefan, I, Fred-Akintunwa, I, Adedotun-Sulaiman, K, Brimmo, FB, Adegboyega, BB, Philip, C, Adeleke, RA, Chukwu, GC, Ahmed, MI, Ope-Ewe, OO, Otitoola, SG, Ogunsanya, OA, Saibu, MF, Sijuwola, AE, Ezekiel, GO, John, OG, Akin-John, JO, Akinlo, OO, Fayemi, OO, Ipaye, TO, Nwodo, DC, Omoniyi, AE, Omwanghe, IB, Terkuma, CA, Okolie, J, Ayo-Ale, O, Ikponmwosa, O, Benevolence, E, Naregose, GO, Patience, AE, Blessing, O, Micheal, A, Jacqueline, A, Aiyepada, JO, Abejegah, C, Adetifa, IM

“…In this study, we integrated genomic and travel data to investigate the emergence and spread of the SARS-CoV-2 B.1.1.318 and B.1.525 (Eta) variants of interest in Nigeria and the wider Africa region. …”

The impact of evolving SARS-CoV-2 mutations and variants on COVID-19 vaccines by McLean, Gary R., Kamil, Jeremy, Lee, Benhur, Moore, Penny, Schulz, Thomas F., Muik, Alexander, Sahin, Ugur, Tureci, Ozlem, Pather, Shanti

“…Data from clinical trials and real-world evidence suggest that current vaccines remain highly effective against the alpha variant (B.1.1.7), while some vaccines have reduced efficacy and effectiveness against symptomatic disease caused by the beta variant (B.1.351) and the delta variant (B.1.617.2); however, effectiveness against severe disease and hospitalization caused by delta remains high. …”
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Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4+ decline by Baxter, J, Villabona-Arenas, J, Thompson, RN, Hue, S, Regoes, R, Kouyos, R, Gunthard, H, Albert, J, Brown, AL, Atkins, K

“…HIV-1 transmission precipitates a stringent genetic bottleneck, with 75% of new infections initiated by a single genetic variant. Where multiple variants initiate infection, recipient set point viral load (SpVL) and the rate of CD4+ 4 T cell decline may be elevated, but these findings remain inconsistent. …”

Southeast Asia initiative to combat SARS-CoV-2 variants (SEACOVARIANTS) consortium by Nhu, LNT, Chambers, M, Chantratita, N, Cheah, PY, Day, NPJ, Dejnirattisai, W, Dunachie, S, Grifoni, A, Hamers, RL, Hill, J, Jones, EY, Klenerman, P, Mongkolsapaya, J, Screaton, G, Sette, A, Stuart, D, Tan, CW, Thwaites, G, Thanh, VD, Wang, L-F, Tan, LV, SEACOVARIANTS Consortium

“…A strong and effective COVID-19 and future pandemic responses rely on global efforts to carry out surveillance of infections and emerging SARS-CoV-2 variants and to act accordingly in real time. Many countries in Southeast Asia lack capacity to determine the potential threat of new variants, or other emerging infections. …”

Germline breast cancer susceptibility genes, tumor characteristics, and survival by Ho, Peh Joo, Khng, Alexis J., Loh, Hui Wen, Ho, Weang-Kee, Yip, Cheng Har, Mohd-Taib, Nur Aishah, Tan, Veronique Kiak Mien, Tan, Benita Kiat-Tee, Tan, Su-Ming, Tan, Ern Yu, Lim, Swee Ho, Jamaris, Suniza, Sim, Yirong, Wong, Fuh Yong, Ngeow, Joanne, Lim, Elaine Hsuen, Tai, Mei Chee, Wijaya, Eldarina Azfar, Lee, Soo Chin, Chan, Ching Wan, Buhari, Shaik Ahmad, Chan, Patrick M. Y., Chen, Juliana J. C., Seah, Jaime Chin Mui, Lee, Wai Peng, Mok, Chi Wei, Lim, Geok Hoon, Woo, Evan, Kim, Sung-Won, Lee, Jong Won, Lee, Min Hyuk, Park, Sue K., Dunning, Alison M., Easton, Douglas F., Schmidt, Marjanka K., Teo, Soo-Hwang, Li, Jingmei, Hartman, Mikael

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