Understanding liver transplantation outcomes through the lens of its tissue-resident immunobiome by Prosser, AC, Klenerman, P, Lucas, M

“…The importance of donor- and recipient-derived TRLs after transplantation is becoming increasingly recognized, although it has not been examined in detail after liver transplantation. This review summarizes the evidence for the roles of TRLs in liver transplant immunology, focusing on their features, functions, and potential for their harnessing to improve transplant outcomes.…”

Predicting graft and patient outcomes following kidney transplantation using interpretable machine learning models by Salaun, A, Knight, S, Wingfield, L, Zhu, T

“…This project uses interpretable methods to predict both graft failure and patient death using data from previously accepted kidney transplant offers. Using more than 25 years of transplant outcome data, we train and compare several survival analysis models in single risk settings. …”

Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

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Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

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Naïve B cells followed by aquaporin-4 antibodies characterise the onset of neuromyelitis optica: evidence from stem cell transplantation by McNaughton, P, Payne, R, Michael, S, Leahy, T, Nicols, A, Fower, A, Hambleton, S, Pang, K, Gennery, A, Irani, SR

Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy by Volpatti, Lisa R, Bochenek, Matthew A, Facklam, Amanda L, Burns, Delaney M, MacIsaac, Corina, Morgart, Alexander, Walters, Benjamin, Langer, Robert, Anderson, Daniel G

“…Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate carriers for glucose‐responsive nanoparticles or islet cells are developed. …”
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Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA by Kelly, DM, Jones, ESW, Barday, Z, Arruebo, S, Caskey, FJ, Damster, S, Donner, J, Jha, V, Levin, A, Nangaku, M, Saad, S, Tonelli, M, Ye, F, Okpechi, IG, Bello, AK, Johnson, DW

“…Public funding (and free at point of delivery) for medications for dialysis and kidney transplantation was available in only 24% (n = 39) and 30% (n = 50) of countries worldwide, with the proportion increasing in line with country income levels. …”

Injectable transplantation system for anticancer in-situ cell therapy by Sheng, Nan.

“…In this project, we are aiming to evaluate the feasibility of remodeling immunosurveillance into the tumor site, with an engineering, more particularly, functional materials-mediated cell therapeutic strategy by designing an injectable cell transplantation system for anti-cancer therapy. The RAW 264.7 cells are encapsulated in dual-layer hydrogel composite which is in injectable size. …”
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Ex vivo expansion and genetic manipulation of mouse hematopoietic stem cells in polyvinyl alcohol-based cultures by Khoo, HM, Meaker, GA, Wilkinson, AC

“…HSCs are used clinically in stem cell transplantation therapies, which represent curative treatment for a range of blood diseases. …”

A qualitative systematic review of anonymous/unspecified living kidney and liver donors' perspectives by Lim, Wen Hui, Chan, Kai En, Ng, Cheng Han, Tan, Darren Jun Hao, Tay, Phoebe Wen Lin, Chin, Yip Han, Yong, Jie Ning, Xiao, Jieling, Fu, Clarissa Elysia, Nah, Benjamin, Tiong, Ho Yee, Syn, Nicholas, Devi, Kamala, Griva, Konstadina, Mak, Loey Lung Yi, Huang, Daniel Q., Fung, James, Siddiqui, Mohammad Shadab, Muthiah, Mark, Tan, Eunice X. X.

“…Methods: A systematic search was conducted on Medline, Embase, CINAHL, PsycINFO, and Web of Science database for qualitative literature regarding unspecified living donors’ motivations and experiences in liver and kidney transplantation. An inductive thematic analysis was conducted to generate themes and supportive subthemes. …”
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Materials approaches for next-generation encapsulated cell therapies by Krishnan, Siddharth R., Langer, Robert, Anderson, Daniel G.

“…However, attack from the host immune system represents a major challenge, requiring chronic immunosuppression to enable long-lived cell transplantation in vivo. Encapsulating cells in engineered biomaterials capable of excluding components of the host immune system while allowing for the transport of therapeutic proteins, oxygen, nutrients, metabolites, and waste products represents a potential solution. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. …”
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Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration by Koh, Mei Shan

“…Currently, the only effective option to treat end stage liver disease is orthopedic liver transplantation. Yet, millions of patient died while waiting for suitable hepatocyte tissue donations. …”
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Magrolimab in combination with azacitidine in patients with higher-risk myelodysplastic syndromes: final results of a phase Ib study by Sallman, DA, Al Malki, MM, Asch, AS, Wang, ES, Jurcic, JG, Bradley, TJ, Flinn, IW, Pollyea, DA, Kambhampati, S, Tanaka, TN, Zeidner, JF, Garcia-Manero, G, Jeyakumar, D, Komrokji, R, Lancet, J, Kantarjian, HM, Gu, L, Zhang, Y, Tan, A, Chao, M, O'Hear, C, Ramsingh, G, Lal, I, Vyas, P, Daver, NG

“…Thirty-four patients (36%) had allogeneic stem-cell transplant with 77% 2-year OS.</p> <br> <p><strong>Conclusion:</strong> Magrolimab + azacitidine was well tolerated with promising efficacy in patients with untreated higher-risk MDS, including those with TP53 mutations. …”