Predicting graft and patient outcomes following kidney transplantation using interpretable machine learning models by Salaun, A, Knight, S, Wingfield, L, Zhu, T

“…This project uses interpretable methods to predict both graft failure and patient death using data from previously accepted kidney transplant offers. Using more than 25 years of transplant outcome data, we train and compare several survival analysis models in single risk settings. …”

Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

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Naïve B cells followed by aquaporin-4 antibodies characterise the onset of neuromyelitis optica: evidence from stem cell transplantation by McNaughton, P, Payne, R, Michael, S, Leahy, T, Nicols, A, Fower, A, Hambleton, S, Pang, K, Gennery, A, Irani, SR

21A.216J / SP.622J / WGS.622J Dilemmas in Bio-Medical Ethics: Playing God or Doing Good?, Spring 2005 by James, Erica

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Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function by Murali, TM, Gu, Y, Minhat, RA, Yap, J, Wood, KJ, Wang, C, Gascoigne, NRJ, Anantharaman, V, MacAry, PA

“…Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many patients with long-term circulating DSAs do not manifest rejection responses, suggesting a degree of heterogeneity in their pathogenicity and related functional activity. …”

Partially Oxidized Alginate as a Biodegradable Carrier for Glucose‐Responsive Insulin Delivery and Islet Cell Replacement Therapy by Volpatti, Lisa R, Bochenek, Matthew A, Facklam, Amanda L, Burns, Delaney M, MacIsaac, Corina, Morgart, Alexander, Walters, Benjamin, Langer, Robert, Anderson, Daniel G

“…Two approaches towards this goal are glucose‐responsive insulin delivery and islet cell transplantation therapy. Here, biodegradable, partially oxidized alginate carriers for glucose‐responsive nanoparticles or islet cells are developed. …”
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Wearable bioadhesive ultrasound shear wave elastography by Liu, Hsiao-Chuan, Zeng, Yushun, Gong, Chen, Chen, Xiaoyu, Kijanka, Piotr, Zhang, Junhang, Genyk, Yuri, Tchelepi, Hisham, Wang, Chonghe, Zhou, Qifa, Zhao, Xuanhe

“…BAUS-E holds promise for clinical applications, particularly in patients after organ transplantation or postoperative care in the intensive care unit (ICU).…”
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Telomere biology disorders by Kam, Michelle L. W., Nguyen, Trang T. T., Ngeow, Joanne Yuen Yie

“…There is no specific cure and the only treatment is organ transplantation, which has poor outcomes. This review summarises the current literature and discusses gaps in understanding and areas of need in managing TBD.…”
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Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA by Kelly, DM, Jones, ESW, Barday, Z, Arruebo, S, Caskey, FJ, Damster, S, Donner, J, Jha, V, Levin, A, Nangaku, M, Saad, S, Tonelli, M, Ye, F, Okpechi, IG, Bello, AK, Johnson, DW

“…Public funding (and free at point of delivery) for medications for dialysis and kidney transplantation was available in only 24% (n = 39) and 30% (n = 50) of countries worldwide, with the proportion increasing in line with country income levels. …”

Injectable transplantation system for anticancer in-situ cell therapy by Sheng, Nan.

“…In this project, we are aiming to evaluate the feasibility of remodeling immunosurveillance into the tumor site, with an engineering, more particularly, functional materials-mediated cell therapeutic strategy by designing an injectable cell transplantation system for anti-cancer therapy. The RAW 264.7 cells are encapsulated in dual-layer hydrogel composite which is in injectable size. …”
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Ex vivo expansion and genetic manipulation of mouse hematopoietic stem cells in polyvinyl alcohol-based cultures by Khoo, HM, Meaker, GA, Wilkinson, AC

“…HSCs are used clinically in stem cell transplantation therapies, which represent curative treatment for a range of blood diseases. …”

A qualitative systematic review of anonymous/unspecified living kidney and liver donors' perspectives by Lim, Wen Hui, Chan, Kai En, Ng, Cheng Han, Tan, Darren Jun Hao, Tay, Phoebe Wen Lin, Chin, Yip Han, Yong, Jie Ning, Xiao, Jieling, Fu, Clarissa Elysia, Nah, Benjamin, Tiong, Ho Yee, Syn, Nicholas, Devi, Kamala, Griva, Konstadina, Mak, Loey Lung Yi, Huang, Daniel Q., Fung, James, Siddiqui, Mohammad Shadab, Muthiah, Mark, Tan, Eunice X. X.

“…Methods: A systematic search was conducted on Medline, Embase, CINAHL, PsycINFO, and Web of Science database for qualitative literature regarding unspecified living donors’ motivations and experiences in liver and kidney transplantation. An inductive thematic analysis was conducted to generate themes and supportive subthemes. …”
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Materials approaches for next-generation encapsulated cell therapies by Krishnan, Siddharth R., Langer, Robert, Anderson, Daniel G.

“…However, attack from the host immune system represents a major challenge, requiring chronic immunosuppression to enable long-lived cell transplantation in vivo. Encapsulating cells in engineered biomaterials capable of excluding components of the host immune system while allowing for the transport of therapeutic proteins, oxygen, nutrients, metabolites, and waste products represents a potential solution. …”
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Targeted hematopoietic stem cell depletion through SCF-blockade by Chan, Yan Y., Ho, Pui Y., Dib, Carla, Swartzrock, Leah, Rayburn, Maire, Willner, Hana, Ko, Ethan, Ho, Katie, Down, Julian D., Wilkinson, Adam C., Nakauchi, Hiro, Denis, Morgane, Cool, Taylor, Czechowicz, Agnieszka

“…Abstract Background Hematopoietic stem cell transplantation (HSCT) is a curative treatment for many diverse blood and immune diseases. …”
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Critical analysis of the role of biodegradable polymeric scaffolds in differentiation of human embryonic stem cell into cardiomyocytes by Amritamayee Sahoo

“…Owing to the shortage of donors there has been a constant quest to find alternatives to organ transplant. Cell replacement therapy is a promising approach for the treatment of cardiac diseases, but is challenged by a limited supply of appropriate cells. …”
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Magrolimab in combination with azacitidine in patients with higher-risk myelodysplastic syndromes: final results of a phase Ib study by Sallman, DA, Al Malki, MM, Asch, AS, Wang, ES, Jurcic, JG, Bradley, TJ, Flinn, IW, Pollyea, DA, Kambhampati, S, Tanaka, TN, Zeidner, JF, Garcia-Manero, G, Jeyakumar, D, Komrokji, R, Lancet, J, Kantarjian, HM, Gu, L, Zhang, Y, Tan, A, Chao, M, O'Hear, C, Ramsingh, G, Lal, I, Vyas, P, Daver, NG

“…Thirty-four patients (36%) had allogeneic stem-cell transplant with 77% 2-year OS.</p> <br> <p><strong>Conclusion:</strong> Magrolimab + azacitidine was well tolerated with promising efficacy in patients with untreated higher-risk MDS, including those with TP53 mutations. …”