Understanding liver transplantation outcomes through the lens of its tissue-resident immunobiome by Prosser, AC, Klenerman, P, Lucas, M

“…The importance of donor- and recipient-derived TRLs after transplantation is becoming increasingly recognized, although it has not been examined in detail after liver transplantation. This review summarizes the evidence for the roles of TRLs in liver transplant immunology, focusing on their features, functions, and potential for their harnessing to improve transplant outcomes.…”

Predicting graft and patient outcomes following kidney transplantation using interpretable machine learning models by Salaun, A, Knight, S, Wingfield, L, Zhu, T

“…This project uses interpretable methods to predict both graft failure and patient death using data from previously accepted kidney transplant offers. Using more than 25 years of transplant outcome data, we train and compare several survival analysis models in single risk settings. …”

Clinical course, immunogenicity, and efficacy of BNT162b2 mRNA vaccination against SARS-CoV-2 infection in liver transplant recipients by Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R. X., Kang, Jaclyn Y. T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby Edward, Muthiah, Mark D.

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21A.216J / SP.622J / WGS.622J Dilemmas in Bio-Medical Ethics: Playing God or Doing Good?, Spring 2005 by James, Erica

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Antigen–antibody complex density and antibody-induced HLA protein unfolding influence Fc-mediated antibody effector function by Murali, TM, Gu, Y, Minhat, RA, Yap, J, Wood, KJ, Wang, C, Gascoigne, NRJ, Anantharaman, V, MacAry, PA

“…Donor-specific antibodies (DSAs) targeting mismatched human leukocyte antigen (HLA) molecules are one of the principal threats to long-term graft survival in solid organ transplantation. However, many patients with long-term circulating DSAs do not manifest rejection responses, suggesting a degree of heterogeneity in their pathogenicity and related functional activity. …”

Wearable bioadhesive ultrasound shear wave elastography by Liu, Hsiao-Chuan, Zeng, Yushun, Gong, Chen, Chen, Xiaoyu, Kijanka, Piotr, Zhang, Junhang, Genyk, Yuri, Tchelepi, Hisham, Wang, Chonghe, Zhou, Qifa, Zhao, Xuanhe

“…BAUS-E holds promise for clinical applications, particularly in patients after organ transplantation or postoperative care in the intensive care unit (ICU).…”
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Telomere biology disorders by Kam, Michelle L. W., Nguyen, Trang T. T., Ngeow, Joanne Yuen Yie

“…There is no specific cure and the only treatment is organ transplantation, which has poor outcomes. This review summarises the current literature and discusses gaps in understanding and areas of need in managing TBD.…”
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Global availability of medications and health technologies for kidney care: A multinational study from the ISN-GKHA by Kelly, DM, Jones, ESW, Barday, Z, Arruebo, S, Caskey, FJ, Damster, S, Donner, J, Jha, V, Levin, A, Nangaku, M, Saad, S, Tonelli, M, Ye, F, Okpechi, IG, Bello, AK, Johnson, DW

“…Public funding (and free at point of delivery) for medications for dialysis and kidney transplantation was available in only 24% (n = 39) and 30% (n = 50) of countries worldwide, with the proportion increasing in line with country income levels. …”

A qualitative systematic review of anonymous/unspecified living kidney and liver donors' perspectives by Lim, Wen Hui, Chan, Kai En, Ng, Cheng Han, Tan, Darren Jun Hao, Tay, Phoebe Wen Lin, Chin, Yip Han, Yong, Jie Ning, Xiao, Jieling, Fu, Clarissa Elysia, Nah, Benjamin, Tiong, Ho Yee, Syn, Nicholas, Devi, Kamala, Griva, Konstadina, Mak, Loey Lung Yi, Huang, Daniel Q., Fung, James, Siddiqui, Mohammad Shadab, Muthiah, Mark, Tan, Eunice X. X.

“…Methods: A systematic search was conducted on Medline, Embase, CINAHL, PsycINFO, and Web of Science database for qualitative literature regarding unspecified living donors’ motivations and experiences in liver and kidney transplantation. An inductive thematic analysis was conducted to generate themes and supportive subthemes. …”
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Hepatogenesis of murine induced pluripotent stem cells in 3D micro-cavitary hydrogel system for liver regeneration by Koh, Mei Shan

“…Currently, the only effective option to treat end stage liver disease is orthopedic liver transplantation. Yet, millions of patient died while waiting for suitable hepatocyte tissue donations. …”
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Critical analysis of the role of biodegradable polymeric scaffolds in differentiation of human embryonic stem cell into cardiomyocytes by Amritamayee Sahoo

“…Owing to the shortage of donors there has been a constant quest to find alternatives to organ transplant. Cell replacement therapy is a promising approach for the treatment of cardiac diseases, but is challenged by a limited supply of appropriate cells. …”
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