Integrated transcriptomic and proteomic profiling of responses to clinical and novel bisphosphonates by Lu, J

“…<p>Bisphosphonates have traditionally been used to treat bone resorptive disorders by inhibiting osteoclast activity. …”

In vitro anti-proliferative mechanism of combination therapy with tannic acid and cisplatin against human osteosarcoma cell line U2OS by Kasiram, Mohamad Zahid Mohd

“…Osteosarcoma is most common primary bone malignancy that affects children and young adults. …”
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Development and characterization of collagen type I and hyaluronic acid (HA) based interlaced scaffolds for tissue engineered heart valves (TEHVS) by Nazir, R

“…Furthermore, the properties of the interlaced scaffolds, fabricated by our crosslinking technique, can be tailored by controlling the crosslinking density which can also widen the scope of these scaffolds for other tissue engineering applications such as bone, cartilage etc.</p>…”

Mitogenic activity of mesenchymal stem cells on hematopoietic stem cells via cellular analysis and gene expression by Mohadeseh, Hashem Boroojerdi

“…It has been recently revealed that the stromal precursor, mesenchymal stem cells (MSC) profoundly regulates the expansion and differentiation of HSC at bone marrow’s niche via producing hematopoietic growth factors and adhesion molecules. …”
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RNA interference silencing of interleukin-6 in mesenchymal stromal cells and antitumour efficacy against multiple myeloma cells by Teoh, Hoon Koon

“…Studies demonstrated that mesenchymal stromal cells (MSC) from bone marrow (BM) stroma produced high concentrations of interleukin-6 (IL-6) that promoted multiple myeloma growth. …”
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Chromatin structuring factor HMGA2 controls subtelomere stability and cancer chemosensitivity by Syed Moiz Ahmed

“…I attribute this wide-spread protection across various cell lines tested in this study to the constrainment of sc DNA and/or catalytic activation of TOP2A mediated by HMGA2, which, remarkably, could provide a mechanistic explanation for the recent observation of poor clinical outcomes in bone-marrow derived mononuclear cells of acute myeloid leukemia patients that express HMGA2. …”
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3D content recovery and complexity reduction by Tan, Cheen Hau

“…To alleviate this problem, we exploit the fact that human bones are rigid and constrain inter-joint distances of connected joints. …”
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Self-learning shape recognition in medical images by Ma, Jingting

“…Experiments are conducted using two representative datasets, a set of 30 public CT kidneys and a set of 49 internal MRI ankle bones. Embedded into an existing segmentation framework, experimental results show that SSM built with the proposed RKPCA outperforms the state-of-the-art modeling techniques in terms of model quality and segmentation accuracy. …”
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