Defining proteoform-specific interactions for drug targeting in a native cell signalling environment by Lutomski, CA, Bennett, JL, El-Baba, TJ, Wu, D, Hinkle, JD, Burnap, SA, Liko, I, Mullen, C, Syka, JEP, Struwe, WB, Robinson, CV

“…Given reports of undesirable side-effects involving vision, we characterized the off-target drug binding of two phosphodiesterase 5 inhibitors, vardenafil and sildenafil, to the retina rod phosphodiesterase 6 (PDE6). …”

Investigation of phenylpropanoid sucrose esters as antidiabetic compounds by Wong, Kathy Pooi Wen

“…However, they are associated with gastrointestinal (GI) side-effects such as diarrhoea, nausea and flatulence. …”
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Viral content: a theory of vaccine hesitancy based on information encountering in the greater Manila area, Philippines by Sacramento, Simon Philip R., Sipin, Ian Dominic P.

“…Background: Ground experiences of the researchers indicate substantial concern about the side-effects of the AstraZeneca vaccine in some individuals who lined up to get vaccinated. …”
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Cellular response to synthetic drugs : a metabolomics approach by Chen, William Wei Ning.

“…The metabolic enzymes identified in our study may in turn be useful targets for future pharmaceutical interventions to reduce clinical side effects following propranolol treatment.…”
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Toward a predict and prevent approach in obstructive airway diseases by Couillard, S, Petousi, N, Smigiel, KS, Molfino, NA

“…Under this framework, undiagnosed and unchecked airway inflammation is associated with recurrent acute attacks, airway remodeling, airflow limitation, adverse effects of corticosteroids, and impaired quality of life, ultimately leading to the collection of side effects termed “people remodeling.” This one-size-fits-all damage control approach aims to control symptoms and treat exacerbations rather than modify the underlying disease process. …”

Corneal re-innervation following refractive surgery treatments by Nur Zahira Yusoff, Yam, Gary Hin-Fai, Mehta, Jodhbir Singh, Bandeira, Francisco

“…Although regarded safe and efficient, it has side effects. All of the laser based refractive surgical procedures invoke corneal nerve injury to some degree. …”
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On-Stack Replacement Across User-Kernel Boundaries by Mohr, Katherine

“…The system discussed in this thesis allows packets which cannot be handled in the kernel to seamlessly continue in user space via on-stack replacement, thus preventing side effects from being executed erroneously. This system for on-stack replacement is very general, allowing execution to switch between code versions at any conditional, and it is novel in its ability to switch stacks across the user-kernel boundary. …”
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The effects of attire and resume placement on asynchronous video interview ratings by Yap, Mica

“…However, there is a dearth of research examining the impact of interview modality on interview ratings, and it is unclear if there are any undesirable side effects of using AVIs. Prior research has found two concerns related to the use of AVIs – applicants may dress more unprofessionally and there is no clear consensus on when in the selection process AVIs should be used. …”
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Integrate Traditional Chinese Medicine (TCM) into cognitive behavioural therapy to treat postpartum depression in Chinese culture contexts. by Han, Shuyu.

“…As in Chinese cultures, it is believed that any kind of drug has certain degree of side effects. In the end, all different kinds of factors have lead to the fact that most women suffering from postpartum disorders or depression left unwell treated. …”
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Diagnosis of sunscreen residue on skin with portable Raman microscope by Li, Yihan

“…One believed way to minimize the potential side effects is to wash TiO2 NPs away from skin at the end of the day. …”
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Modeling and control of an HVAC system by Zhang, Xiang

“…Future improvement can be done on systems integration, minimizing the side effects of the actions on other parts of the HVAC system.…”
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Toxicological evaluation of Sargassum polycystum in mice with loperamide-induced constipation by Chittipong Tipbunjong, Tanaporn Hengpratom, Saranya Peerakietkhajorn, Jaruwan Mayakun, Nawiya Huipao, Pissared Khuituan, Piyaporn Surinlert, Chumpol Pholpramool

“…Until now, there have been no effective drugs without side effects. This study investigated the preventive potential and toxicity of Sargassum polycystum extract (SPE) against loperamide-induced constipation in mice. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Whether or not monomeric S1 shedding has an effect on the vaccine antibody response or could be implicated in the observed rare side effects, remains to be investigated but evidence from other studies implicates this occurrence as detrimental in animal models.…”

High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants by Chan-Park, Mary B., Beuerman, Roger W., Zhang, Quanyuan, Fang, Zheng, Cao, Ye, Du, Huamao, Wu, Hong, Duan, Hongwei, Xu, Rong

“…The use of artificial cornea implants has received increasing attention for treating cornea-related diseases and vision errors due to the low side effects. To achieve long-term successful vision correction, stable and biocompatible materials of high refractive index (RI) need to be developed. …”
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Comparing user behavior when targeted based on firm inferred interest vs. user stated interest by Cao, Yiqun(Scientist in business management)Massachusetts Institute of Technology.

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Nanomaterials for biomolecules sensing : germanene modified screen printed electrodes for the chronoamperometric detection of histamine in fish samples by Veronica Pereira

“…High histamine consumption could lead to scombroid poisoning that has serious side effects such as hypertension, vomiting and diarrhoea. …”
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Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice by Traut, J, Mengual, JP, Meijer, E, McKillop, L, Alfonsa, H, Hoerder-Suabedissen, A, Song, SH, Fehér, KD, Riemann, D, Molnar, Z, Akerman, CJ, Vyazovskiy, VV, Krone, LB

“…This implies that back-metabolism to clozapine is not the sole mechanism underlying side effects of chemogenetic actuators. Therefore, any chemogenetic experiment should include a DREADD-free control group injected with the same CNO, C21, or newly developed actuator. …”

Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives by Rabadà, Yvette, Bosch-Sanz, Oriol, Biarnés, Xevi, Pedreño, Javier, Caveda, Luis, Sánchez-García, David, Martorell, Jordi, Balcells, Mercedes

“…Two of the molecules of this family have shown activity that is greater than or similar to that of tranexamic acid (TXA), the current antifibrinolytic gold standard, which has been associated with several side effects and whose use is limited in patients with renal impairment. …”
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Accumulated decoupled learning with gradient staleness mitigation for convolutional neural networks by Zhuang, Huiping, Weng, Zhenyu, Luo, Fulin, Toh, Kar-Ann, Li, Haizhou, Lin, Zhiping

“…Gradient staleness is a major side effect in decoupled learning when training convolutional neural networks asynchronously. …”
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Efgartigimod efficacy and safety in refractory myasthenia gravis: UK’s first real-world experience by Moniz Dionísio, J, Ambrose, P, Burke, G, Farrugia, ME, Garcia-Reitboeck, P, Hewamadduma, C, Hill, M, Howard, RS, Jacob, S, Kullmann, D, Leite, MI, Miller, J, Pinto, A, Pritchard, J, Riswick, T, Sathasivam, S, Thambirajah, N, Viegas, S, Norwood, F, Spillane, J

“…The mean intracycle reduction in the MG-ADL score in the first, second, third and fourth cycles were −4.6 to –3.9, −3.4 and −4.2, respectively. Side effects were generally mild. No rescue treatments were required. …”