Tinospora crispa ethanolic extract downregulates Protein Kinase genes expression and activity during Toxoplasma gondii infection: a prospective drug target for lytic cycle inhibiti... by Abdullahi, Sharif Alhassan, Nordin, Norshariza, Unyah, Ngah Zasmy, Basir, Rusliza, Daneji, Isa Muhammad, Nasiru, Wana Mohammed, Majid, Roslaini Abd

“…The infection is poorly controlled due to lack of a potent vaccine against the parasite, and the current medication presents severe side effects on the host, less efficacy on the parasite and is accompanied by the potential development of resistance by the parasite. …”
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Camel Milk and Oxidative stress: Therapeutic potential against metabolic syndrome diseases by Musa, Khalid Hamid, Hamad, Essam M., Elnour, Ahmed Adam Hassan Mohammed

“…Standardization of production and processing is essential for quality and safety, and research into potential risks and side effects is needed, especially for those with specific health conditions. …”
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Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii by Yang, Yuchen

“…Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins offer advantages like enhanced specificity and reduced side effects, and there has been tremendous growth in their innovation thanks to modern DNA technologies and AI-driven algorithms. …”
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From Transparency to Accountability and Back by Cen, Sarah, Alur, Rohan

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Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery by Connor, Christopher W

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Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys by Mockenhaupt, Stefan, Grosse, Stefanie, Rupp, Daniel, Bartenschlager, Ralf, Grimm, Dirk

“…However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including off-target gene regulation. Here, we address this concern with a novel strategy that reduces sense strand activity of vector-encoded shRNAs via codelivery of inhibitory tough decoy (TuD) RNAs. …”
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The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Combination csDMARDs have shown some superiority over single therapies but there are limited data and concerns about side effects. Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. Conclusion: Our study underscores the critical importance of community-based screening in detecting undiagnosed hypertension. …”

Anti-ageing properties of edible bird's nest ascertained by in vitro and in vivo studies in animal model by Hou, Zhiping

“…Hormone replacement therapy (HRT) has been used to restore postmenopausal hormonal levels in order to relieve menopausal problems, but its associated side effects including development of cancers and cardiovascular diseases have necessitated the search for other alternatives such as natural food supplementation. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice by Loke, Mun Fai, Vadivelu, Jamuna, Tan, Tuan Lin, Wong, Whye Yen, Khosravi, Yalda, Seow, Shih Wee, Amoyo, Arlaine Anne, Chiow, Kher Hsin, Poh, Qian Hui, Sentosa, Ignatius Mario Doli, Bunte, Ralph M., Pettersson, Sven

“…Further investigations of possible additional side effects of H. pylori are highly warranted.…”
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Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

“…Therefore, this delivery system is a promising platform to control the delivery of NSAIDs to combat inflammatory diseases, thereby protecting against possible gastrointestinal side effects that may arise from the overuse of NSAIDs.…”
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Virtual reality as a countermeasure for astronaut motion sickness during simulated post-flight water landings by Lonner, T. L., Allred, A. R., Bonarrigo, L., Gopinath, A., Smith, K., Kravets, V., Groen, E. L., Oman, C., DiZio, P., Lawson, B. D., Clark, T. K.

“…Anticholinergic pharmaceuticals (e.g., Meclizine) are often taken prior to landing; however, they have operationally adverse side effects (e.g., drowsiness). There is a need to develop non-pharmaceutical countermeasures to EMS. …”
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Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Medical chemists still have many challenges because of the high side effects, increasing tumor resistance, and low selectivity of new chemotherapeutic medications despite the enormous effort put out to extract, develop, and synthesize them. …”
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Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

“…Systemic injection of most cytokines has only shown modest clinical benefits, while associated with significant side-effects akin to chronic inflammation. Local, targeted delivery of cytokines in tumour sites is beneficial to achieve high therapeutic dose within tumour while limiting systemic dose. …”
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Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…Combination therapies that exploit different ways to treat cancer cells, while minimising adverse side-effects, have gained increased traction in recent years. …”

Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Oral squamous cell carcinoma (OSCC), a major oral cancer, significantly challenges treatments and impacts patient quality of life; current therapies often cause severe side effects, highlighting the urgent need for gentler alternatives. …”
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Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis by von Mässenhausen, Anne, Schlecht, Marlena Nastassja, Beer, Kristina, Maremonti, Francesca, Tonnus, Wulf, Belavgeni, Alexia, Gavali, Shubhangi, Flade, Karolin, Riley, Joel S., Zamora Gonzalez, Nadia, Brucker, Anne, Becker, Jorunn Naila, Tmava, Mirela, Meyer, Claudia, Peitzsch, Mirko, Hugo, Christian, Gembardt, Florian, Angeli, Jose Pedro Friedmann, Bornstein, Stefan R., Tait, Stephen W. G., Linkermann, Andreas

“…Finally, as ferroptosis contributes to a variety of pathophysiological processes, we cannot exclude side effects in human siRNA-based therapeutical concepts that should be clinically tested.…”
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Hospitalised patients as stewards of their own antibiotic therapy: a qualitative analysis informing the strategic design of interventions to encourage shared decision-making in ter... by Guo, Huiling, Lye, David C., Ng, Tat Ming, Somani, Jyoti, Kwa, Andrea Lay Hoon, Chung, Jasmine Shimin, Chow, Angela

“…Highlighting potential side effects of antibiotics could motivate them to ask questions about their antibiotic therapies. …”
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Formulation and in-vitro release study of drug loaded liposomes for treating dry eye disease by Chua, Yan Ni

“…In addition, there is a need to also ensure a controlled release of drug in order to minimise drug toxicity which may lead to side effects in the body. In this project, we will be reporting the use of liposomal drug delivery system, to encapsulate the hydrophobic drug (Senicapoc) in its hydrophobic bilayer and aim to administer this formulation as an eye drop for the management of Dry Eye Disease (DED). …”
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