Enzyme-responsive nanoparticles for drug release and diagnostics by Rica, Roberta de la, Aili, Daniel, Stevens, Molly M.

“…When combined with the unique physical properties of nanomaterials, the resulting enzyme-responsive nanoparticles can be designed to perform functions efficiently and with high specificity for the triggering stimulus. This powerful concept has been successfully applied to the fabrication of drug delivery schemes where the tissue of interest is targeted via release of cargo triggered by the biocatalytic action of an enzyme. …”
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DECA : recovering fields of physical quantities from incomplete sensory data by Vasilakos, Athanasios V., Xiang, Liu, Luo, Jun, Deng, Chenwei, Lin, Weisi

“…Whereas the existing recovery schemes only tackle the second aspect, we develop Dual-lEvel Compressed Aggregation (DECA) as a novel framework to address both aspects. Specifically, DECA allows a high fidelity recovery of a widespread event, under the situations that the WSN only sparsely covers the event area and that an in-network data aggregation is applied for traffic reduction. …”
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Budget allocation management model for seismic rehabilitation of infrastructure assets. by Mohammadreza Yadollahi

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Gap analysis of social science resources for conservation practice by Detoeuf, D, de Lange, E, Ibbett, H, Gupta, T, Solis, CM, Mavakala, K, Catapani, M, Kretser, HE, Milner-Gulland, EJ, Brittain, S, Newing, H, Fariss, B, Spira, C, Eyster, HN, DeMello, N, Wallen, KE, Thornton, SA, Bennett, NJ, Choo, LL

“…Most resources available open-access (90%) and half were specific to conservation practice. Together, results reveal a need for (a) organization leaders to prioritize social sciences in conservation, (b) a greater diversity of accessible training resources in alternate mediums and languages, (c) resources tailored to conservation contexts, and (d) additional ethics and human rights and data analysis resources.…”

Modeling polarity-driven laminar patterns in bilayer tissues with mixed signaling mechanisms by Moore, JW, Dale, TC, Woolley, TE

“…Motivated by cellular mechanisms that control cell-fate decisions in developing bilayer tissues, we use dynamical systems coupled with multilayer graphs to analyze the role of signaling polarity and pathway crosstalk in fine-grain pattern formation of protein activity. Specifically, we study how multilayer graph edge structures and weights influence the layerwise (laminar) patterning of cells in bilayer structures, which are commonly found in glandular tissues. …”

Apocryphal Joyce: fuga per canonem by Holtkamp, G

“…</p> <p>With the frame of the canon and the canonical versus 'hidden writing' and the apocryphal this dissertation traces Joyce's various styles of interrogating canonical, authoritative discourse through transgressive or illicit forms of writing. Specifically, this dissertation shows how these various 'apocryphal modes' of Joyce converge as a growing movement of flight. …”

A review of life cycle assessment methods to inform the scale-up of carbon dioxide removal interventions by Butnar, I, Lynch, J, Vetter, S

“…Our results show that whilst providing valuable life cycle understanding, current practices utilise diverse methods, usually attributional in nature, which are CDR and time specific. As a result, they do not allow comprehensive cross-comparison between CDRs, nor reveal potential consequences of scaling up CDRs in the future. …”

The global Multidimensional Poverty Index (MPI) 2024 disaggregation results and methodological note by Alkire, S, Kanagaratnam, U, Suppa, N

“…Section 6 summarises the country-specific decisions that were applied for the new or updated datasets in this round. …”

Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence by Sapey, E, Greenwood, H, Walton, G, Mann, E, Love, A, Aaronson, N, Insall, RH, Stockley, RA, Lord, JM

“…PI3K-blocking strategies, specifically inhibition of PI3Kγ or PI3Kδ, restored neutrophil migratory accuracy, whereas SHIP1 inhibition worsened migratory flaws. …”

Attentional control of goal directed behaviour by King, R

“…</p> <p>The second part is comprised of two empirical chapters aimed at more specific experimental questions. These chapters propose novel paradigms aimed at answering finer grained questions regarding the structure of attentional control.…”

Long-term effects of early life rainfall shocks on foundational cognitive skills: evidence from Peru by Pazos, N, Favara, M, Sánchez, A, Scott, D, Behrman, J

“…We also find evidence of rainfall shocks decreasing households’ abilities to invest in human capital, which may affect both FCSs and domain-specific test scores. Finally, there is suggestive, but not conclusive, evidence that a conditional-cash-transfer program providing poor households with additional financial resources might partially offset the effects of the rainfall shocks.…”

Predicting rifampicin resistance in M. tuberculosis using machine learning informed by protein structural and chemical features by Lynch, C, Adlard, D, Fowler, P

“…</p> <br> <p><strong>Results:</strong> All four models behaved similarly with sensitivities and specificities in and 0.94-0.97 although we preferred the ensemble of Decision Tree models as inspect and understand. …”

Conversion, ethnology, and law in the conquest of the Philippines by Cobo, NC

“…While the historiography has generally glossed over the limitations and silences of extant sources, this thesis centres their complicated and fragmented nature and reflects on the specificity of the archipelago. In place of the established problematic clean narrative of these early years, it instead advances a new interpretation of how the Spanish conquest happened, arguing that the invaders initially integrated into extant patterns of raiding and trading before a paradigmatic shift to conquest; and of the complex development of the colonial enterprise, examining the external and internal challenges it faced, demonstrating that it was far from secure, and exploring how these threats and the anxieties they generated fundamentally shaped how the colonial administration developed. …”

Enhancing exemplar SVMs using part level transfer regularization by Aytar, Y, Zisserman, A

“…<br> EE-SVM is evaluated both quantitatively and qualitatively on the PASCAL VOC 2007 and ImageNet datasets for pose specific object retrieval. It achieves a significant performance improvement over E-SVMs, with greater suppression of negative detections and increased recall, whilst maintaining the same ease of training and testing.…”

Upconversion nanoparticles-modified aptasensors for highly sensitive mycotoxin detection for food quality and safety by Bahari, H-R, Mousavi Khaneghah, A, Eş, I

“…Aptasensors, incorporating aptamers as specific recognition elements, are crucial for mycotoxin detection due to their remarkable sensitivity and selectivity in identifying target mycotoxins. …”

Heritable polygenic editing: the next frontier in genomic medicine? by Visscher, PM, Gyngell, C, Yengo, L, Savulescu, J

“…To date, no attempts have been made to predict the consequences of altering specific variants associated with polygenic diseases. …”

Charting the irreversible degradation modes of low bandgap Pb-Sn perovskite compositions for de-risking practical industrial development by Kamaraki, C, Klug, MT, Lim, VJ, Zibouche, N, Herz, LM, Islam, MS, Case, C, Perez, LM

“…<p>The commercialization of a solar technology necessitates the fulfillment of specific requirements both regarding&nbsp;efficiency and stability to enter and gain space in the photovoltaic market. …”

Tidal corrections from and for SWOT using a spatially coherent variational Bayesian harmonic analysis by Monahan, T, Tang, T, Roberts, S, Adcock, T

“…These data present both the opportunity and the necessity to quantify and correct the spatial variability in the model inaccuracies specific to these regions. We develop a variational Bayesian framework for tidal harmonic analysis which can be applied to SWOT, and is especially useful for exploting the data from the Cal/Val phase. …”

Exploring the mechanisms of coordinated chick provisioning in the Manx shearwater Puffinus puffinus by Gillies, N, Tyson, C, Wynn, J, Syposz, M, Vansteenberghe, C, Guilford, TC

“…We used a combination of observational data and experimental manipulation to examine the mechanisms that may underlie this behaviour. Specifically, we investigated the evidence that physical reunion is necessary to induce a switch in trip type, whether parents change their behaviour to maximise the probability of partner encounter, and whether indirect cues gained from the chick could inform a switch in behaviour. …”

Drafting ‘Anon’ and killing anon: Virginia Woolf and the genesis of English literary language by Phillips, J

“…This chapter examines the unfinished drafts of the literary history that Virginia Woolf worked on in the final year of her life, a project that Woolf variously termed ‘Reading at Random’ and ‘Turning the Page’ but which has come to be known by the dual title of ‘Anon’ and ‘The Reader.’ Specifically, this chapter posits that through its content and its form, the drafts of ‘Anon’ dramatize the work of genetic narratology, and doubly so. …”