Identifying primary care clinicians' preferences for, barriers to, and facilitators of information-seeking in clinical practice in Singapore: a qualitative study by Lee, Mauricette Moling, Tang, Wern Ee, Smith, Helen Elizabeth, Car, Lorainne Tudor

“…Trial registration: This study has been reviewed by NHG Domain Specific Review Board (NHG DSRB) (the central ethics committee) for ethics approval. …”
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Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans by Xu, Luang, Liu, Xinyu, Sheng, Na, Oo, Kyaw Soe, Liang, Junxin, Chionh, Yok Hian, Xu, Juan, Ye, Fuzhou, Gao, Yong-Gui, Dedon, Peter C., Fu, Xin-Yuan

“…We found that methyltransferase-like (METTL) 2 and 6 contribute m3C in specific tRNAs and that METTL8 only contributes m3C to mRNA. …”
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Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 by Bhattacharjee, NV, Schumacher, AE, Aali, A, Almidani, O, Bandyopadhyay, S, Graham, SM, Lacey, BWH, Maude, RJ, Runghien, T, Rodriguez, JAB

“…Livebirths were calculated by multiplying ASFR and age-specific female population, then summing across ages 10–54 years. …”

A polydopamine-modified garnet–based polymer-in-ceramic hybrid solid electrolyte membrane for high-safety lithium metal batteries by Hailu Mengesha, Tadesu, Lemma Beshahwured, Shimelis, Wu, Yi–Shiuan, Wu, She–Huang, Jose, Rajan, Yang, Chunchen

“…Benefiting from this stable interfacial contact, an Al2O3@NCM811/CSE1/Li coin-type cell provided a discharge specific capacity of 136.46 mAh/g at a rate of 0.5C after 300 cycles, with a capacity retention of 86.22 % and a average coulombic efficiency of 99.16 % at 25 °C. …”
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The capabilities of Multiclass Support Vector Machine (MSVM) training algorithms in grading agarwood essential oil by Anis Hazirah ‘Izzati H., Al-Hadi, Siti Mariatul Hazwa, Mohd Huzir, Nurlaila, Ismail, Zakiah, Mohd Yusoff, Saiful Nizam, Tajuddin, Mohd Nasir, Taib

“…The model's performance evaluation results were recorded, with all criteria, including accuracy, sensitivity, specificity, and precision, achieved 100%. In conclusion, the model has the capabilities to identify significant agarwood essential oil chemical compounds and separate agarwood essential oil grades into five and six with high accuracy using eleven significant compounds based on the classification evaluated on two different grades of agarwood essential oil.…”
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p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice by Vernì, Fiammetta, Saggio, Isabella, Burla, Romina, La Torre, Mattia, Zanetti, Giorgia, Bastianelli, Alex, Merigliano, Chiara, Del Giudice, Simona, Vercelli, Alessandro, Di Cunto, Ferdinando, Boido, Marina

“…In addition, it further underscores the importance of model organisms for studying specific phenotypes, along with permitting the analysis of genetic interactions at the organismal level.…”
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Scaffold-mediated sustained, non-viral delivery of miR-219/miR-338 promotes CNS remyelination by Milbreta, Ulla, Lin, Junquan, Pinese, Coline, Ong, William, Chin, Jiah Shin, Shirahama, Hitomi, Mi, Ruifa, Williams, Anna, Bechler, Marie E., Wang, Jun, ffrench-Constant, Charles, Hoke, Ahmet, Chew, Sing Yian

“…Using spinal cord injury as a proof-of-concept, we further demonstrate that miR-219/miR-338 could also be delivered non-virally in vivo using an aligned fiber-hydrogel scaffold to enhance remyelination after a hemi-incision injury at C5 level of Sprague-Dawley rats. Specifically, miR-219/miR-338 mimics were incorporated as complexes with the carrier, TransIT-TKO (TKO), together with neurotrophin-3 (NT-3) within hybrid scaffolds that comprised poly(caprolactone-co-ethyl ethylene phosphate) (PCLEEP)-aligned fibers and collagen hydrogel. …”
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The hazards of unconfined pyroclastic density currents: a new synthesis and classification according to their deposits, dynamics, and thermal and impact characteristics by Lerner, Geoffrey A., Jenkins, Susanna F., Charbonnier, Sylvain J., Komorowsk, Jean-Christophe, Baxter, Peter J.

“…Despite their ability to cause serious impacts, unconfined PDCs have previously only been described for a limited number of specific case studies. Here, we carry out a broader comparative study that reviews the different types of unconfined PDCs, their deposits, dynamics and impacts, as well as the relationships between each element. …”
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Whence came these plants most foul? Phylogenomics and biogeography of Lowiaceae (Zingiberales) by Niissalo, Matti A., Gardner, Elliot M., Khew, Gillian S., Šída, Otakar, Poulsen, Axel Dalberg, Leong-Škornicková, Jana

“…We sampled the family extensively, including many recently discovered species, and reconstructed the phylogeny of the family using HybSeq with Lowiaceae-specific RNA baits. Our phylogenetic reconstructions confirm that the family is most closely related to Strelitziaceae, and that species with dark, foul-smelling flowers form a grade in which a clade of species with paler flowers are embedded. …”
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Automated lesion segmentation and quantification for prediction of paradoxical worsening in patients with tubercular serpiginous-like choroiditis by Kalra, Gagan, Agarwal, Aniruddha, Marchese, Alessandro, Agrawal, Rupesh, Bansal, Reema, Gupta, Vishali

“…Using a sensitivity optimized threshold cut-off for mean pixel intensity, an area under the curve of 0.87 was achieved (sensitivity: 96.80% and specificity: 72.09%). Automated calculation of lesion metrics such as mean pixel intensity and segmented area in TB SLC is a novel approach with good repeatability in predicting PW during the follow-up.…”
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Adjoint-state differential arrival time tomography by Tong, Ping, Li, Tianjue, Chen, Jing, Nagaso,Masaru

“…One advantage of differential arrival time data is that it cancels or reduces the influence of common factors, making it more sensitive to a specific subset of model parameters compared to first arrival times. …”
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PESI: paratope-epitope set interaction for SARS-CoV-2 neutralization prediction by Wan, Zhang, Lin, Zhuoyi, Rashid, Shamima, Ng, Shaun Yue Hao, Yin, Rui, Senthilnath, J., Kwoh, Chee Keong

“…In this paper, we propose a novel approach that incorporates only the paratope and epitope for antibody-antigen neutralization prediction while adopting a novel set modeling that regards the paratope and epitope as bags of residues. Specifically, we hand-crafted a dataset containing neutralizing paratope-epitope pairs where epitopes are potentially generalizable to future unseen variants of SARS-CoV-2. …”
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A novel quasi-cubic CuFe2O4–Fe2O3 catalyst prepared at low temperature for enhanced oxidation of bisphenol A via peroxymonosulfate activation by Oh, Wen-Da, Dong, Zhili, Hu, Zhong-Ting, Lim, Teik-Thye

“…The FESEM and BET characterization studies revealed that the CuFe2O4–Fe2O3 catalyst has a quasi-cubic morphology and specific surface area of 63 m2 g−1. The performance of CuFe2O4–Fe2O3 as a PMS activator was compared with those of other catalysts and the results indicated that the performance was in the following order: CuFe2O4–Fe2O3 > CuFe2O4 > CoFe2O4 > CuBi2O4 > CuAl2O4 > Fe2O3 > MnFe2O4. …”
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Organizational Architecture Design and Assessment of Statistical Feasibility for NPM Implementation in an Airplane Subassembly by Daigle, Lea (Lea A.)

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Non-linear Log-Sobolev Inequalities for the Potts Semigroup and Applications to Reconstruction Problems by Gu, Yuzhou, Polyanskiy, Yury

“…This recovers previous results (of Sly in Commun Math Phys 288(3):943–961, 2009 and Bhatnagar et al. in SIAM J Discrete Math 25(2):809–826, 2011) in (slightly) more generality, but more importantly avoids the need for any coloring-specific arguments. Similarly, we improve the state-of-the-art on the weak recovery threshold for the stochastic block model with q balanced groups, for all $$q\ge 3$$ q ≥ 3 . …”
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Cosystolic Expansion of Sheaves on Posets with Applications to Good 2-Query Locally Testable Codes and Lifted Codes by First, Uriya A., Kaufman, Tali

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Exploring connections between seagrass ecosystem services and meadow hydrodynamics by Schaefer, Rachel

“…One vegetated patch showed substantially higher sediment carbon than the rest of the meadow, which was attributed to the recent persistence of the specific patch. In addition, preliminary results for a field study comparing different methods of estimating net ecosystem carbon exchange in a seagrass meadow are also presented.…”
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Modeling and Implementation of the U.S. Hydrogen Production Tax Credit by Giovanniello, Michael A.

“…Applying a macro-energy systems model to case studies of Texas and Florida, we show that divergent results in the literature, which presented a conundrum for regulators trying to pick between policy options, are explained by different interpretations of the proposed “additionality” requirement. Specifically, the emissions associated with H2 production under different “time-matching” requirements are conditional on how additionality is modeled. …”
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Understanding Chromatin Organization and Dynamics with Coarse-Grained Modeling by Liu, Shuming

“…In the future, we will focus on benchmarking our models and existing CG models with condensate simulations, which enables more appropriate selections of CG models based on specific conditions. In Chapter 3, we introduce OpenABC, a versatile toolkit designed to streamline the setup of CG simulations, especially condensate simulations. …”
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UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract by Stritt, Kevin, Roth, Beat, Masnada, Audrey, Hammann, Felix, Jacot, Damien, Domingos-Pereira, Sonia, Crettenand, François, Bohner, Perrine, Sommer, Isabelle, Bréat, Emilien, Sauser, Julien, Derré, Laurent, Haschke, Manuel, Collins, James J., McKinney, John

“…The primary outcome is the comparative incidence of postoperative urinary tract infections (assessed at 48 h) between the investigational amikacin/mannitol therapy and standard (ceftriaxone or amikacin) antibiotic prophylaxis, defined by specific systemic symptoms and/or positive blood and/or urine culture. …”
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