Ultrasound-compatible 3D-printed Franz diffusion system for sonophoresis with microbubbles by Chen, Xin, De Grandi, Davide, Zhu, Yonglian, Lutheryn, Gareth, Lane, Majella E., Sil dos Santos, Bruno, Carugo, Dario

“…To overcome this limitation, we designed and manufactured a novel Franz cell donor compartment coupled with a conventional glass receptor, and performed a functional characterisation of the assembly for application in sonophoresis with ultrasound-responsive agents (specifically imiquimod-loaded gas microbubbles). The donor was fabricated using a photoreactive resin via 3D printing and was designed to enable integration with a therapeutically relevant ultrasound source. …”
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Moral panic, fear, stigma, and discrimination against returnee migrants and Muslim populations in Nepal: analyses of COVID-19 media content by Aryal, Nirmal, Regmi, Pramod, Dhakal Adhikari, Shovita, Sharma, Shreeman, van Teijlingen, Edwin

“…During the first phase of the COVID-19 pandemic, some media content in Nepal tended to create moral panic and public fear towards specific sub- groups in the population. This study explored the content published in the mainstream and social media for their role in creating public fear and stereotypes which were particularly focused on returnee migrants and Muslim populations living in Nepal and the subsequent impact on these population groups. …”
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Environmental, social, and governance (ESG) reporting and missing (M) scores in the Industry 5.0 era: broadening firms’ and investors’ decisions to achieve sustainable development... by Yadav, Sanjeev, Samadhiya, Ashutosh, Kumar, Anil, Luthra, Sunil, Pandey, Krishan Kumar

“…To handle the critical shift to wider sustainable development goals (SDGs) specifically, SDG 8 (Decent Work and Economic Growth) and SDG 13 (Climate Action) within the ESG monitoring system, this research digs into current ESG reporting concerns and obstacles. …”
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Applying liquisolid technique to enhance curcumin solubility: a central composite design study by Aghajanpour, Sareh, Yousefi Jordehi, Shabnam, Farmoudeh, Ali, Negarandeh, Reza, Lam, Matthew, Ebrahimnejad, Pedram, Nokhodchi, Ali

“…Turmeric, specifically its curcuminoids such as curcumin (C21H20O6), possesses extensive therapeutic benefits including anti-inflammatory, anticancer, and anti-aging properties. …”
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Darwin-scepticism and mass persuasion: an examination of propaganda in the Evolution Wars by Aechtner, T

“…This dissertation seeks to help answer this question by uniquely considering a crucial piece of the modern Evolution Wars puzzle: <em>propaganda</em>. Specifically, this study contends that propaganda is a decisive element of this science-religion controversy, and that its sociological significance is not merely derived from the merits of its communicated arguments, but by the degree of its media persuasiveness. …”

The role of tumour necrosis factor alpha stimulated gene-6 on bone by Afrough, S

“…</p> <p>Contrary to its previously reported inhibitory effects on osteoblastogenesis, this thesis shows, for the first time, that TSG-6 displays context-specific anabolic properties. This finding implies a therapeutic value for the protein, with possibilities of being used in conjunction with BMP-2 to treat local bone injuries such as fractures.…”

A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder by Sullivan, SA, Kounali, D, Cannon, M, David, AS, Fletcher, PC, Holmans, P, Jones, H, Jones, PB, Linden, DEJ, Lewis, G, Owen, MJ, O'Donovan, M, Rammos, A, Thompson, A, Wolke, D, Heron, J, Zammit, S

“…Incidence rates were estimated using flexible parametric modeling, and positive predictive values (PPVs), sensitivity, specificity, and area under the curve were estimated for prediction. …”

Interventions that prevent or reduce perinatal loneliness and its proximal determinants: a restricted scoping review by Naughton-Doe, R, Nowland, R, Tierney, S, Webber, M, Wittkowski, A

“…Few studies collected comprehensive demographic data, few considered fathers, and none were LGBTQ+ specific.</p> <p><strong>Conclusions</strong> The review identified and synthesised approaches that might address perinatal loneliness and its proximate determinants. …”

Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Liu, D, Wang, N, Song, M, Chai, X, He, Q, Cao, T, Kong, D, Song, Z, Zhang, G, Liu, L, Wang, X, Chen, G, Yin, S, Yang, Y, Zhao, J

“…There was an 85% correct classification between MCS and UWS, with 88% sensitivity and 81% specificity for MCS. The best classification rate in the derivation cohort was achieved at a metabolic index of 3.32 (41% of the mean cortical metabolic index in healthy controls). …”

Evaluation of CareStart™ malaria HRP2/pLDH (Pf/PAN) combo rapid diagnostic test for diagnosis of Plasmodium falciparum infection in malaria co-endemic areas in association with par... by Christian, M, Ekawati, LL, Pratama, AR, Cahyaningati, S, Bere, HK, Rustam, M, Kalbuadi, I, Andini, J, Yuliana, J, Fadilah, I, Ley, B, Thriemer, K, Price, RN, Sutanto, I, Baird, JK

“…The sensitivity and specificity of HRP2 band were 97.3% (95% CI 93.3–99.2) and 97.6% (95% CI 94.0–99.4), respectively, while that of pLDH band were 87.3% (95% CI 81.1–92.0) and 100% (95% CI 97.7–100). …”

Effectiveness and user experience of nose and throat swabbing techniques for SARS-CoV-2 detection: results from the UK COVID-19 National Testing Programme by Futschik, ME, Kulasegaran-Shylini, R, Blandford, E, Harper, S, Chapman, D, Turek, E, Agrawal, S, Phillips, V, Fordham, H, Chan, L, Kidd, M, Dodgson, A, Klapper, PE, Sudhanva, M, Vipond, R, Hopkins, S, Peto, T, Tunkel, S, Fowler, T

“…Outcomes included observational user feedback on swabbing approaches and quantitative testing performance (concordance, sensitivity, and specificity). A post-hoc indirect comparison of swabbing approaches was also performed. …”

Artificial intelligence–derived risk prediction: a novel risk calculator using office and ambulatory blood pressure by Guimarães, P, Keller, A, Böhm, M, Lauder, L, Fehlmann, T, Ruilope, LM, Vinyoles, E, Gorostidi, M, Segura, J, Ruiz-Hurtado, G, Staplin, N, Williams, B, de la Sierra, A, Mahfoud, F

“…However, the prediction of cardiovascular mortality with ABP instead of OBP data significantly increased the area under the curve (0.870 versus 0.865;&nbsp;<em>P</em>=3.61&times;10^&minus;²⁸), accuracy, and specificity, respectively. The prediction of ABP phenotypes (ie, white-coat, ambulatory, and masked hypertension) using clinical characteristics was limited.…”

Publishers’ and journals’ instructions to authors on use of generative artificial intelligence in academic and scientific publishing: bibliometric analysis by Ganjavi, C, Eppler, MB, Pekcan, A, Biedermann, B, Abreu, A, Collins, GS, Gill, IS, Cacciamani, GE

“…When disclosing the use of GAI, 75% of publishers and 43% of journals included specific disclosure criteria. Where to disclose the use of GAI varied, including in the methods or acknowledgments, in the cover letter, or in a new section. …”

Characterising the metabolic functionality of the preterm neonatal gut microbiome prior to the onset of necrotising enterocolitis: a pilot study by Chapman, JA, Wroot, E, Brown, T, Beck, LC, Embleton, ND, Berrington, JE, Stewart, CJ

“…Comparisons across all 16 samples showed the NEC microbiota to have greater utilisation of carbon sources that are the products of proteolytic fermentation, specifically amino acids. In pairwise comparisons, L-methionine was highly utilised in NEC samples, but poorly utilised in controls (p = 0.043). …”

Exploiting signed TV broadcasts for automatic learning of British Sign Language by Buehler, P, Everingham, M, Zisserman, A

“…In this work, we will present several contributions towards automatic recognition of BSL signs from continuous signing video sequences. Specifically, we will address 3 main points: (i) automatic detection and tracking of the hands using a generative model of the image; (ii) automatic learning of signs from TV broadcasts of single signers, using only the supervisory information available from subtitles; and (iii) discriminative signer-independent sign recognition using automatically extracted training data from a single signer. …”

Clinical value of cell-based assays in the characterisation of seronegative myasthenia gravis by Damato, V, Spagni, G, Monte, G, Woodhall, M, Jacobson, L, Falso, S, Smith, T, Iorio, R, Waters, P, Irani, SR, Vincent, A, Evoli, A

“…<p><strong>Objective </strong></p>Patients with myasthenia gravis without acetylcholine receptor (AChR) or muscle-specific kinase (MuSK) antibodies detected by radioimmunoprecipitation assays (RIAs) are classified as seronegative myasthenia gravis (SNMG). …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps and... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, KS

“…Recent studies (mostly numerical) have shown the importance of testing at engine representative conditions, specifically targeting the transonic tip flow in a high-speed rotational environment, which is essential for an accurate understanding.…”

IGF-1R expression is associated with HPV-negative status and adverse survival in head and neck squamous cell cancer by Dale, OT, Aleksic, T, Shah, KA, Han, C, Mehanna, H, Rapozo, DCM, Sheard, JDH, Goodyear, P, Upile, NS, Robinson, M, Jones, TM, Winter, S, Macaulay, VM

“…Overall survival (OS) and disease-specific survival (DSS) were reduced in patients whose tumors contained high membrane IGF-1R [OS: hazard ratio (HR) = 1.63, P = 0.006; DSS: HR = 1.63, P = 0.016], cytoplasmic IGF-1R (OS: HR = 1.58, P = 0.009; DSS: HR = 1.58, P = 0.024) and total IGF-1R (OS: HR = 2.02, P &lt; 0.001; DSS: HR = 2.2, P &lt; 0.001). …”

HELMET: a hybrid machine learning framework for real-time prediction of edema trajectory in large middle cerebral artery stroke by Phillips, E, O'Donoghue, O, Zhang, Y, Tsimpos, P, Mallinger, LA, Chatzidakis, S, Pohlmann, J, Du, Y, Kim, I, Song, J, Brush, B, Smirnakis, S, Ong, CJ, Orfanoudaki, A

“…Our work enables accurate estimation of complex, dynamic, and highly specific clinical targets, such as midline shift, in real-time, even when relevant structured information is limited in electronic health record databases.…”

Precision holography and supersymmetric theories on curved spaces by Genolini, P

“…The latter requires specific geometric structures, and general arguments imply that BPS observables, such as the partition function, are invariant under certain deformations of these structures. …”