Nanomechanical adaptation of early apoptotic cell shrinkage to materials interface by Cai, Pingqiang

“…Based on this, we conducted a systematic evaluation by interfacing cells with substrates specifically engineered (e.g. through substrate elasticity and geometric constraints) to modulate the two factors. …”
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Near-infrared light for phototherapy : photothermal induced drug release and tumor ablation by Li, Menghuan

“…Chapter 3 describes one of my attempts to combine the specifically functionalized polymer with gold nanorods for a controllable drug delivery system. …”
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Formulation and in-vitro release study of drug loaded liposomes for treating dry eye disease by Chua, Yan Ni

“…Size and drug loading of liposomes were performed at specific intervals over a period of 28 days at both temperatures of 4oC and 37oC to study the stability of the formulation. …”
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Chemical composition and dynamics of biofilm matrix in hydrated, live Shewanella oneidensis biofilms by Ding, Yuanzhao

“…The objective of this study was to explore the use of dynamic molecular imaging method to obtain chemical composition and dynamics of biofilm matrix in growing biofilms. Specifically, Shewanella oneidensis was used as a model organism and a novel technique combining System for Analysis at the Liquid Vacuum Interface (SALVI) with Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) was applied to elucidate chemical composition and dynamics of S. oneidensis biofilm matrix. …”
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Novel nitric oxide donors for the dispersal and control of Pseudomonas aeruginosa biofilms by Poh, Wee Han

“…In the second study, the application of cephalosporin-linked diazeniumdiolate NO donors, which are stable until activation by bacterial specific β-lactamases present within biofilms, were evaluated. …”
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Development of the CHARIOT Research Register for the Prevention of Alzheimer’s Dementia and Other Late Onset Neurodegenerative Diseases by Larsen, Mark E., Curry, Lisa, Mastellos, Nikolaos, Robb, Catherine, Car, Josip, Middleton, Lefkos T.

“…The CHARIOT register was designed specifically to support recruitment into observational natural history studies of pre-symptomatic or prodromal dementia stages, and primary or secondary prevention pharmaceutical trials or other prevention strategies for dementia and other cognitive problems associated with ageing. …”
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A unified framework of active transfer learning for cross-system recommendation by Zhao, Lili, Pan, Sinno Jialin, Yang, Qiang

“…In this paper, we propose a new transfer learning framework for recommender systems, which relaxes the above assumption to facilitate flexible knowledge transfer across different systems with low cost by using an active learning principle to construct entity correspondences across systems. Specifically, for the purpose of maximizing knowledge transfer, we first iteratively select entities in the target system based on some criterion to query their correspondences in the source system. …”
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Three physiological responses in fathers and non-fathers’ to vocalizations of typically developing infants and infants with Autism Spectrum Disorder by Esposito, Gianluca, Valenzi, Stefano, Islam, Tanvir, Bornstein, Marc H.

“…These findings point to similarities and differences in fathers’ and non-fathers’ physiological responsiveness to cries of children with ASD and might guide specific intervention programs for parents of children at risk of ASD.…”
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Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS) by Lawton, Jennifer, Brugat, Thibaut, Yan, Yam Xue, Reid, Adam James, Böhme, Ulrike, Otto, Thomas Dan, Pain, Arnab, Jackson, Andrew, Berriman, Matthew, Cunningham, Deirdre, Preiser, Peter Rainer, Langhorne, Jean

“…In addition, some differences were observed in the pattern of expression between the cir subgroups at the peak of P. chabaudi infection. Finally, specific cir genes were expressed at different time points during asexual blood stages. …”
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Young people's understanding of European values: enhancing abilities, supporting participation and voice by Ross, Alistair, Loughran, Tom, Brunold, Andreas, Hartsmar, Nanny, Liljefors Persson, Bodil, Chistolini, Sandra, Dotta, Leanete Thomas, Freires, Thiago, Kõiv, Kristi, Lopes, Juliana Crespo, Pembecioğlu, Nilüfer, Pereira, Fátima, Spinthourakis, Julia Athena

“…Each is introduced in turn, and for each there is • an overview of the value in the current European context: its source in the Convention and the Charter, and its development and contemporary meaning; • an analysis of how young people discussed the value – • differences in different Regions of Europe, and • differences in the characteristic descriptions, by timing, location, and type of othering (described in statistics and by illustrative quotations of remarks by young people) • a discussion of the implications of this for pedagogic practice about furthering the understanding of the specific value. D An analysis of regional and other factors. …”
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Surface water sensitivity to climate variability by Paltan-Lopez, H

“…To demonstrate the value of the framework, this thesis presents four case studies in which specific components and sub-models of this framework are utilized to address the mentioned objectives.…”

Cadê o Kauê? Co-design and acceptability testing of a chat-story aimed at enhancing youth participation in the promotion of mental health in Brazil by Pavarini, G, Murta, SG, Mendes, JAA, Siston, FR, Souza, RRA, Cunha, RO, Ferreira, JA, Santos, VHL, Seabra, BTR, Talk2U, Singh, I

“…This paper discusses the co-design and acceptability testing of a chat-story intervention to enhance Brazilian adolescents' participation in the promotion of mental health in their peer communities. We specifically highlight the iterative process of co-creating this intervention with community stakeholders.…”

Parallel transmission technologies for imaging the brain and body with 7 tesla MRI by Kent, JL

“…Although, in order to provide a robust subject-specific improvement the non-uniform radiofrequency field must first be mapped in a process known as “B1+ mapping”.…”

The association between hip morphology parameters and 19-year risk of end-stage osteoarthritis of the hip in caucasian females: a case-control study by Nicholls, AS

“…</p> <p>In order to conduct this investigation, we developed and validated a new software program specifically designed for measuring 23 selected morphological parameters in the pelvis, acetabulum and proximal femur. …”

Views and uses of sepsis / deterioration digital alerts in NHS Trusts in England: a qualitative study with healthcare professionals by Lazzarino, R, Borek, AJ, Honeyford, K, Welch, J, Brent, AJ, Kinderlerer, A, Cook, G, Patil, S, Gordon, A, Glampson, B, Goodman, P, Ghazal, P, Daniels, R, Costelloe, CE, Tonkin-Crine, S

“…Advancements toward minimally disruptive and smart digital alerts as sepsis or deterioration CCDSSs, which are more accurate and specific but at the same time scalable and accessible, require policy changes and investments in multidisciplinary research.…”

Histone lysine and DNA methylation: dynamic marks in the chromatin by Belle, R

“…However, the relative high number of structurally related proteins and corresponding domains found in humans consisting of KMTs (SET: ~25), KDMs (JumonjiC domain: ~25) and chromatin binding modules (tudor domain (TD): ~25; plant homeodomain (PHD): >100) makes it challenging to produce both potent and specific inhibitors. The development of inhibitors for Nε-trimethyllysine chromatin binding modules to date, have been plagued with relatively weak inhibition but also with off-target effects. …”

PARP1 resolves DNA replication defects in PCNA-associated DNA repair disorder by Wang, L

“…The aim of this thesis was to determine cellular pathways that are affected by the S228I alteration and to uncover mechanisms by which PCNAS^228I cells tolerate the perturbed PCNA interactions in specific pathways. </p> <p>An isogenic PCNAS^228I knock-in hTERT RPE-1 cell line was generated using CRISPR-Cas9 technique. …”

The paradoxes of wind power by Keay, M

“…Furthermore, the economics of wind power are affected by two trends which tend to move in opposite directions – on the one hand, as the technology improves, costs tend to fall; on the other, since the costs are site specific, the best sites tend to be used first so leading to a rising cost curve over time. …”

Accuracy and safety of an autonomous artificial intelligence clinical assistant conducting telemedicine follow-up assessment for cataract surgery by Meinert, E, Milne-Ives, M, Lim, E, Higham, A, Boege, S, de Pennington, N, Bajre, M, Mole, G, Normando, E, Xue, K

“…Dora R1 demonstrated an overall outcome sensitivity of 94% and specificity of 86% and showed moderate to strong agreement (kappa: 0.758&ndash;0.970) with clinicians in all parameters. …”

Emotion language in context: investigating emotion words in children’s written language and word learning by Dong, Y

“…Preliminary analyses revealed that reading experience was a significant predictor of the lexical diversity of their overall narrative production, but not for the production of emotion words specifically, despite the positive correlation between reading experience and emotion word production. …”