p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice by Vernì, Fiammetta, Saggio, Isabella, Burla, Romina, La Torre, Mattia, Zanetti, Giorgia, Bastianelli, Alex, Merigliano, Chiara, Del Giudice, Simona, Vercelli, Alessandro, Di Cunto, Ferdinando, Boido, Marina

“…In addition, it further underscores the importance of model organisms for studying specific phenotypes, along with permitting the analysis of genetic interactions at the organismal level.…”
Get full text
Get full text

Scaffold-mediated sustained, non-viral delivery of miR-219/miR-338 promotes CNS remyelination by Milbreta, Ulla, Lin, Junquan, Pinese, Coline, Ong, William, Chin, Jiah Shin, Shirahama, Hitomi, Mi, Ruifa, Williams, Anna, Bechler, Marie E., Wang, Jun, ffrench-Constant, Charles, Hoke, Ahmet, Chew, Sing Yian

“…Using spinal cord injury as a proof-of-concept, we further demonstrate that miR-219/miR-338 could also be delivered non-virally in vivo using an aligned fiber-hydrogel scaffold to enhance remyelination after a hemi-incision injury at C5 level of Sprague-Dawley rats. Specifically, miR-219/miR-338 mimics were incorporated as complexes with the carrier, TransIT-TKO (TKO), together with neurotrophin-3 (NT-3) within hybrid scaffolds that comprised poly(caprolactone-co-ethyl ethylene phosphate) (PCLEEP)-aligned fibers and collagen hydrogel. …”
Get full text

The hazards of unconfined pyroclastic density currents: a new synthesis and classification according to their deposits, dynamics, and thermal and impact characteristics by Lerner, Geoffrey A., Jenkins, Susanna F., Charbonnier, Sylvain J., Komorowsk, Jean-Christophe, Baxter, Peter J.

“…Despite their ability to cause serious impacts, unconfined PDCs have previously only been described for a limited number of specific case studies. Here, we carry out a broader comparative study that reviews the different types of unconfined PDCs, their deposits, dynamics and impacts, as well as the relationships between each element. …”
Get full text

Whence came these plants most foul? Phylogenomics and biogeography of Lowiaceae (Zingiberales) by Niissalo, Matti A., Gardner, Elliot M., Khew, Gillian S., Šída, Otakar, Poulsen, Axel Dalberg, Leong-Škornicková, Jana

“…We sampled the family extensively, including many recently discovered species, and reconstructed the phylogeny of the family using HybSeq with Lowiaceae-specific RNA baits. Our phylogenetic reconstructions confirm that the family is most closely related to Strelitziaceae, and that species with dark, foul-smelling flowers form a grade in which a clade of species with paler flowers are embedded. …”
Get full text

Automated lesion segmentation and quantification for prediction of paradoxical worsening in patients with tubercular serpiginous-like choroiditis by Kalra, Gagan, Agarwal, Aniruddha, Marchese, Alessandro, Agrawal, Rupesh, Bansal, Reema, Gupta, Vishali

“…Using a sensitivity optimized threshold cut-off for mean pixel intensity, an area under the curve of 0.87 was achieved (sensitivity: 96.80% and specificity: 72.09%). Automated calculation of lesion metrics such as mean pixel intensity and segmented area in TB SLC is a novel approach with good repeatability in predicting PW during the follow-up.…”
Get full text

Adjoint-state differential arrival time tomography by Tong, Ping, Li, Tianjue, Chen, Jing, Nagaso,Masaru

“…One advantage of differential arrival time data is that it cancels or reduces the influence of common factors, making it more sensitive to a specific subset of model parameters compared to first arrival times. …”
Get full text

PESI: paratope-epitope set interaction for SARS-CoV-2 neutralization prediction by Wan, Zhang, Lin, Zhuoyi, Rashid, Shamima, Ng, Shaun Yue Hao, Yin, Rui, Senthilnath, J., Kwoh, Chee Keong

“…In this paper, we propose a novel approach that incorporates only the paratope and epitope for antibody-antigen neutralization prediction while adopting a novel set modeling that regards the paratope and epitope as bags of residues. Specifically, we hand-crafted a dataset containing neutralizing paratope-epitope pairs where epitopes are potentially generalizable to future unseen variants of SARS-CoV-2. …”
Get full text

A novel quasi-cubic CuFe2O4–Fe2O3 catalyst prepared at low temperature for enhanced oxidation of bisphenol A via peroxymonosulfate activation by Oh, Wen-Da, Dong, Zhili, Hu, Zhong-Ting, Lim, Teik-Thye

“…The FESEM and BET characterization studies revealed that the CuFe2O4–Fe2O3 catalyst has a quasi-cubic morphology and specific surface area of 63 m2 g−1. The performance of CuFe2O4–Fe2O3 as a PMS activator was compared with those of other catalysts and the results indicated that the performance was in the following order: CuFe2O4–Fe2O3 > CuFe2O4 > CoFe2O4 > CuBi2O4 > CuAl2O4 > Fe2O3 > MnFe2O4. …”
Get full text
Get full text

Organizational Architecture Design and Assessment of Statistical Feasibility for NPM Implementation in an Airplane Subassembly by Daigle, Lea (Lea A.)

Get full text

Non-linear Log-Sobolev Inequalities for the Potts Semigroup and Applications to Reconstruction Problems by Gu, Yuzhou, Polyanskiy, Yury

“…This recovers previous results (of Sly in Commun Math Phys 288(3):943–961, 2009 and Bhatnagar et al. in SIAM J Discrete Math 25(2):809–826, 2011) in (slightly) more generality, but more importantly avoids the need for any coloring-specific arguments. Similarly, we improve the state-of-the-art on the weak recovery threshold for the stochastic block model with q balanced groups, for all $$q\ge 3$$ q ≥ 3 . …”
Get full text

Cosystolic Expansion of Sheaves on Posets with Applications to Good 2-Query Locally Testable Codes and Lifted Codes by First, Uriya A., Kaufman, Tali

Get full text

Exploring connections between seagrass ecosystem services and meadow hydrodynamics by Schaefer, Rachel

“…One vegetated patch showed substantially higher sediment carbon than the rest of the meadow, which was attributed to the recent persistence of the specific patch. In addition, preliminary results for a field study comparing different methods of estimating net ecosystem carbon exchange in a seagrass meadow are also presented.…”
Get full text

Modeling and Implementation of the U.S. Hydrogen Production Tax Credit by Giovanniello, Michael A.

“…Applying a macro-energy systems model to case studies of Texas and Florida, we show that divergent results in the literature, which presented a conundrum for regulators trying to pick between policy options, are explained by different interpretations of the proposed “additionality” requirement. Specifically, the emissions associated with H2 production under different “time-matching” requirements are conditional on how additionality is modeled. …”
Get full text
Get full text

Understanding Chromatin Organization and Dynamics with Coarse-Grained Modeling by Liu, Shuming

“…In the future, we will focus on benchmarking our models and existing CG models with condensate simulations, which enables more appropriate selections of CG models based on specific conditions. In Chapter 3, we introduce OpenABC, a versatile toolkit designed to streamline the setup of CG simulations, especially condensate simulations. …”
Get full text

UROPOT: study protocol for a randomized, double-blind phase I/II trial for metabolism-based potentiation of antimicrobial prophylaxis in the urological tract by Stritt, Kevin, Roth, Beat, Masnada, Audrey, Hammann, Felix, Jacot, Damien, Domingos-Pereira, Sonia, Crettenand, François, Bohner, Perrine, Sommer, Isabelle, Bréat, Emilien, Sauser, Julien, Derré, Laurent, Haschke, Manuel, Collins, James J., McKinney, John

“…The primary outcome is the comparative incidence of postoperative urinary tract infections (assessed at 48 h) between the investigational amikacin/mannitol therapy and standard (ceftriaxone or amikacin) antibiotic prophylaxis, defined by specific systemic symptoms and/or positive blood and/or urine culture. …”
Get full text

From Sample to Answer: Innovations in sample processing and CRISPR-based diagnostics for enhanced clinical translation and field deployment by Arizti Sanz, Jon

“…CRISPR-Dx are easily programmable, robust, sensitive, isothermal, and highly specific, but further advances will be required to facilitate their use outside of centralized laboratories. …”
Get full text

Secure Computation in Decentralized Systems by Zyskind, Guy

“…The research employs Secure Multiparty Computation (MPC) techniques to address these issues, demonstrating how MPC, which already shares a similar distributed trust threat model, can enhance privacy in decentralized systems. More specifically, this thesis focuses on the following key areas in decentralized systems: Access Control Mechanisms and Confidential Smart Contracts: The thesis begins by exploring access control mechanisms on blockchains, and from that builds up to the concept of confidential smart contracts -- arbitrary programs that execute both correctly and privately. …”
Get full text
Get full text

Using Principles from Cognitive Science to Analyze and Guide Language-Related Neural Networks by Tucker, Mycal

“…Utility represents a measure of task success and induces task-specific communication; informativeness is a task-agnostic measure of how well listeners understand speakers and leads to generalizable communication; complexity captures how many bits are allocated for communication and can lead to simpler communication systems. …”
Get full text

Nanoscale Origins of Thermal Transport Phenomena for Hybrid Layered Perovskites by Dahod, Nabeel S.

“…This experimental study reveals that even in terms of their thermal transport pathways, 2D LHPs can be treated as composite materials. Specifically, lead bromide 2D LHPs exhibit structure-property relationships characteristic of ballistic phonon transport within isolated subphases and diffuse scattering at the organic-inorganic interfaces between layers. …”
Get full text

A review of extended-range operations by transport aircraft by Simpson, R. W., Ausrotas, Raymond A.

Get full text