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221
Multimodal cell-free DNA whole-genome TAPS is sensitive and reveals specific cancer signals
Published 2025“…We conduct a diagnostic accuracy study across multiple cancer types in symptomatic patients, achieving 94.9% sensitivity and 88.8% specificity. Matched tumour biopsies are used for validation, not for guiding the analysis, imitating an early detection scenario. …”
Journal article -
222
In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery
Published 2025Journal article -
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Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor
Published 2018Subjects: “…Post-translational Modification…”
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Journal Article -
225
Application of magnetic field for reduction of sludge bulking in activated sludge system
Published 2024Subjects: “…Sewage—Purification—Activated sludge process…”
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226
Biogranules containing photosynthetic bacteria for carbon dioxide reduction in palm oil mill effluent treatment
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Thesis -
227
Struvite precipitation for the recovery of ammonium nitrogen from landfill leachate
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Thesis -
228
Electrode modification by diazonium chemistry : studies on the effect of steric bulk on film thickness, and modified activated carbon cloths for energy storage
Published 2021“…The chemical modification of electrode surfaces with organic molecules is an important reaction in electrochemistry. …”
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Thesis-Doctor of Philosophy -
229
Tricyclononenes and tricyclononadienes as efficient monomers for controlled ROMP: understanding structure–propagation rate relationships and enabling facile post-polymerization modification
Published 2024“…Furthermore, the TCND diester—which contains an electron-deficient cyclobutene that is resistant to ROMP—and its polymer p(TCND) are shown to be highly reactive toward DBU-catalyzed conjugate addition reactions with thiols, providing a protecting- and activating-group free strategy for post-polymerization modification.…”
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Article -
230
Ball with hair: modular functionalization of highly stable G-quadruplex DNA nano-scaffolds through N2-guanine modification
Published 2017“…Furthermore, these modifications stabilize the G-quadruplex scaffold by 2.0–13.3 °C per modification in the melting temperature, with concurrent modifications producing extremely stable nano-scaffolds. …”
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Journal Article -
231
Strain-specific parallel evolution drives short-term diversification during Pseudomonas aeruginosa biofilm formation
Published 2014“…Mutations were found to be strain specific: the mucoid strain 18A experienced mutations in alginate production genes and a c-di-GMP regulator gene; while PA01 acquired mutations in PilT and PilY1, possibly in response to a rapid expansion of a lytic Pf4 bacteriophage, which may use type IV pili for infection. …”
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Journal Article -
232
Novel single-step hydrophobic modification of polymeric hollow fiber membranes containing imide groups : its potential for membrane contactor application
Published 2013“…Poly(amide–imide) (PAI) hollow fiber membrane with controlled pore structure as porous substrate was fabricated by dry-jet wet spinning process, followed by a wet-chemical hydrophobic modification using octadecylamine. The modification mechanism was confirmed by ATR-FTIR, and the effect of different modification times on the modified membrane properties was investigated. …”
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Journal Article -
233
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Discovery of glucose-specific, peptide-based carbohydrate mimics using phage displayed random peptide libraries.
Published 2009“…Phage displayed random peptide libraries were used to discover peptides which functionally mimic the monosaccharide glucose by screening these libraries against glucose-specific lectins. Although the screening of phage display libraries against single lectins has been previously reported, debate exists whether the resulting peptides are indeed true sugar mimics or merely act as ligands for the targeted lectin. …”
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Thesis -
236
Distilling crowd knowledge from software-specific Q&A discussions for assisting developers’ knowledge search
Published 2018“…In addition, the decay of information quality such as misspelling, inconsistency, and abuse of domain-specific abbreviations aggravates the search performance. …”
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Thesis -
237
Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
Published 2018“…Our study characterizes a druggable allosteric pocket which appears to be specific to certain oncogenic mutants of the EGFR and holds therapeutic potential.…”
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Journal Article -
238
DNA extraction methodologies for ultra long nanopore sequencing to determine chromosome specific rodent telomere lengths
Published 2024“…Direct sequencing of highly repetitive stretches of DNA is difficult, using specific DNA extraction techniques and adaptive sampling and tagging approaches for targeted enrichment has generated chromosome specific ultralong reads in rodents.…”
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Conference or Workshop Item -
239
An epitope-specific LGI1-autoantibody enhances neuronal excitability by modulating Kv1.1 channel
Published 2022“…Patient-derived recombinant monoclonal antibodies (mAbs) are ideal reagents to study whether domain-specific LGI1-autoantibodies induce epileptiform activities in neurons and their downstream mechanisms. …”
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240
Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies
Published 2024“…To better understand ventricle-specific molecular changes influencing heart failure development, we first performed unbiased quantitative mass spectrometry on pre-mortem non-diseased human myocardium to compare the metabolome and proteome between the normal left and right ventricles. …”
Journal article