Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior by Ahumada-Marchant, Constanza, Ancatén-Gonzalez, Carlos, Haensgen, Henny, Brauer, Bastian, Merino-Veliz, Nicolas, Droste, Rita, Arancibia, Felipe, Horvitz, H. Robert, Constantine-Paton, Martha, Arriagada, Gloria, Chávez, Andrés E., Bustos, Fernando J.

“…Understanding the mechanisms controlling behaviors and synaptic function in ASD-associated mutations is pivotal for the development of targeted interventions, which may open new avenues for therapeutic strategies aimed at ASD and related conditions.…”
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Domain wall pinning through nanoscale interfacial Dzyaloshinskii-Moriya interaction by Kumar, Durgesh, Chan, Jianpeng, Piramanayagam, S. N.

“…Research studies have indicated that domain wall (DW) devices are one of the most energy-efficient contenders for realizing NC. Moreover, synaptic functions can be achieved by obtaining multi-resistance states in DW devices. …”
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Understanding early molecular mechanisms of abnormal myelination in neurological conditions by characterising Ermin deficiency by Oh, Sher Li, Ziaei, Amin, Tan, Liang Juin, Utami, Kagistia Hana, Pouladi, Mahmoud A., Langley, Sarah Raye

“…We observed altered expression of transcription factors at early ages, and in protein processing and synaptic function over time. In silico gene perturbation and ChIP-seq analysis were used to elucidate the roles that differentially expressed transcription factors play in oligodendrocyte differentiation and as well as in their effects on protein processing and synaptic function. …”
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MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress by Rodrigues, B, Leitão, RA, Santos, M, Trofimov, A, Silva, M, Inácio, ÂS, Abreu, M, Nobre, RJ, Costa, J, Cardoso, AL, Milosevic, I, Peça, J, Oliveiros, B, Pereira de Almeida, L, Pinheiro, PS, Carvalho, AL

“…However, the molecular links between chronic stress and its deleterious effects on neuronal and synaptic function remain elusive. Here, using a combination of in vitro and in vivo approaches, we demonstrate that the upregulation of miR-186-5p triggered by chronic stress may be a key mediator of such changes, leading to synaptic dysfunction. …”

Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model by Emmerson, JT, Do Carmo, S, Lavagna, A, Huang, C, Wong, TP, Martinez-Trujillo, JC, Cuello, AC

“…However, this tau-induced protective effect on synaptic function was transient. As anticipated, at more advanced stages, the APPxhTau bigenic rats exhibited aggravated tau and amyloid pathologies, cognitive decline, increased neuroinflammation, and tau-driven neuronal loss compared to monogenic rat models of Alzheimer’s-like amyloid and tau pathologies. …”