Understanding the justifications for food policies through political theory: a method for public policy analysis by Thomas, O

“…</p> <p>The analysis of these topics led to the creation of a series of claims related to the ethics of sugar interventions, notably: that thinking about culture and the values instantiated in specific cultures is important when thinking about justifying policies; that we should re-frame debates around equity to focus on groups and communities; that different conceptions of liberty are useful to a different extent depending on the policy context; and that there are good reasons to embrace paternalistic interventions in health. …”

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 by Steinmetz, JD, Seeher, KM, Schiess, N, Bennett, DA, Maude, RJ, Newton, CRJ, Rodriguez, JAB

“…<p><b>Findings</b></p> Globally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. …”

Introduction - Oxford Energy Forum – Issue, 98

“…Latin American NOCs, a handful of medium-sized regional players, and newly formed companies for specific opportunities clearly dominate the landscape and have seen more success than any industry group.</p> <p>In this issue of the Forum we cover several regional themes that will shed some light onto the challenges and opportunities for the region, as well as some specific country themes.…”

Congenital myasthenic syndromes: characterisation of a new animal model, exploring potential novel therapies and assessing the outcome of COVID-19 infection by Alabaf, S

“…Some lead to postsynaptic acetylcholine receptor (AChR) deficiency or altered receptor kinetic properties and in a group of patients with CMS, the mutations impair clustering of AChRs. …”

Autoinhibition releasing provides a platform for developing p21-activated kinase-1 (PAK1) activators for hypertrophic heart diseases by He, Y

“…Moreover, the oral treatment of PAK1 activators in a transgenic hypertrophic cardiomyopathy (HCM) mouse model, expressing the mutation ACTC1E99K, demonstrated notable enhancements in cardiac function and reduced progression of fibrosis in HCM mice compared to the vehicle group.</p> <p>In summary, our strategy, targeting the autoinhibition release site DEK motif within PAK1 and discovering allosteric PAK1 activators, unveils a unique direction for developing protein kinase activators. …”

Development of a national maternity early warning score: centile based score development and Delphi informed escalation pathways by Gerry, S, Bedford, J, Redfern, OC, Rutter, H, Chester-Jones, M, Kelly, T, Watkinson, PJ, Knight, M

The influence of pregnancy complications on fetal and neonatal cardiovascular development by Aye, C

“…These microvascular changes were not, however, correlated with cardiac hypertrophy in the whole cohort over the same period, but, intriguingly, when subgroup analysis was performed, increased microvascular density loss was correlated with increased left ventricular mass indexed to body size at three months of age in term born infants but not in the preterm group.</p> <p>It was then shown that preterm offspring had reduced heart rate variability measures at birth suggesting autonomic dysfunction. …”

Investigating the role of CDK1 in governing the transcriptional landscape in cancer cells by Pluta, AJ

“…The literature suggests a binary distinction between cell-cycle CDKs and transcriptional CDKs (tCDKs), but increasing evidence points to the functional overlap between these groups. Considering the need for temporal coordination of the cell cycle and the transcription cycle, it can be speculated that the CDKs might play a critical role in linking the two processes. …”

Relationship of sperm protamine content with bull breeding soundness evaluation and sperm DNA damage by Mohamed Abbad Alfadel, Fatima

“…The results of sperm DNA damage were differed significantly across the three time points, affected by the sperm protamine content for each bull’s group. Post hoc pairwise comparison showed an increased DNA damage in bulls with lower protamine values. …”
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Cytotoxicity assessment of α helix Antarctic yeast oriented antifreeze peptide (Afp1m) on M. dunni (Clone III8C) cells by Khan, Muhammad Shuaib, Abdul Rahman, Mohd Basyaruddin, Abu Bakar, Mohd Zuki, Noordin, Mohammed Mustapha, Ullah, Shakeeb, Abdul Abubakar, Adamu, Rehman, Saifur, Saddiqua, Aisha, Mohammad Yusof, Loqman

“…The findings of this work indicate that Afp1m exhibits cryoprotective properties without inducing toxicity when used for the cryopreservation of M. dunni (Clone III8C) cells. were cul t ured wi t h 10% FBS (Foet al Bovine Serum) using an Elisa reader and in medium containing various amounts (10, 5, 2, 1 and 0.5 mg/mL) of Afp1m, the control group (10% FBS) displayed varying survival percentages (78.86 ± 10.17%, 88.38 ± 3.19%, 88.75 ± 7.19 %, 90.61 ± 7.11%, 91.19 ± 4.52%, and 100.00 ± 0.0 %) throughout 24 hr. …”
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Ergogenic and metabolites analyses of piyarom date (Phoenix dactylifera L.) using NMR-based metabolomics and its effect on Sprague dawley rats by Shanan, Hana Kadum

“…In NMR-based on metabolomics data, OPLS-DA showed clear distinct separation between treated and fatigue group’s treatment. Furthermore, the OPLS-DA plots showed that metabolites of the rats fed of high dose of date extract were very similar to that of normal rats, which was not obvious in rats treated with the low dose of the extract or that of caffeine. …”
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The development and validation of digital medical education environment (digimee) instrument in measuring online learning environment for undergraduate medical students by Haris, Noor-I-Kiran

“…The study was designed as a multi-phase mixed- methods research project conducted in online settings involving a diverse group of experts, teachers, and instructional designers and multiple medical colleges in Pakistan ( Phase 2 and 3), spanning 18 months. …”
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Compatibility and combination of world W-boson mass measurements by Amoroso, S., Andari, N., Barter, W., Bendavid, J., Boonekamp, M., Farry, S., Grünewald, M., Hays, C., Hunter, R., Kretzschmar, J., Lupton, O., Pili, M., Ramos Pernas, M., Tuchming, B., Vesterinen, M., Vicini, A., Wang, C., Xu, M.

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Association of PHACTR1 with Coronary Artery Calcium Differs by Sex and Cigarette Smoking by Voorhies, Kirsten, Young, Kendra, Hsu, Fang-Chi, Palmer, Nicholette D., McDonald, Merry-Lynn N., Lee, Sanghun, Hahn, Georg, Hecker, Julian, Prokopenko, Dmitry, Wu, Ann Chen, Regan, Elizabeth A., DeMeo, Dawn, Kinney, Greg L., Crapo, James D., Cho, Michael H., Silverman, Edwin K., Lange, Christoph, Budoff, Matthew J., Hokanson, John E., Lutz, Sharon M.

“…We adjusted for age, sex, current smoking status, BMI, diabetes, self-reported high blood pressure, self-reported high cholesterol, and genetic ancestry (as summarized by principal components computed within each racial group). For the significant signals from the GWA analyses, we examined the single nucleotide polymorphism (SNP) by sex interactions, stratified by smoking status (current vs. former), and tested for a SNP by smoking status interaction on CAC. …”
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发达地区失地老人养老支持体系内卷化及其突破 — 基于苏州市的个案研究 = The involution of the eldercare system for the landless elderly in China’s developed regions : a case study based on Suzhou municipality... by 叶继红 Ye Jihong, 占少华 Zhan Shaohua

“…因此，为解决养老内卷化问题，需要提升失地农民的社会保障待遇，充分发挥传统养老机制的优势，发展社区嵌入式养老机构，缩小征地范围，规避失地风险。As a special group in the process of rural urbanization and land acquisition, the old people who lost their land are facing the practical problems regarding eldercare service provision. …”
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Identifying influential parameters of octahedrally coordinated cations in spinel ZnMnₓCo₂–ₓO₄ oxides for the oxidation reaction by Wang, Ting, Sun, Yuanmiao, Zhou, Ye, Sun, Shengnan, Hu, Xiao, Dai, Yihu, Xi, Shibo, Du,Yonghua, Yang, Yanhui, Xu, Zhichuan Jason

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inPhocus: current state and challenges of phage research in Singapore by Verma, Navin Kumar, Tan, Si Jia, Chen, John, Chen, Hanrong, Muhammad Hafiz Ismail, Rice, Scott A., Bifani, Pablo, Hariharan, , Sukumar, Paul, , Vivek Daniel, Sriram, Bharathi, Dam, Linh Chi, Chan, Chia Ching, Ho, Peiying, Goh, Boon Chong, Chung, Jasmine Shimin, Goh, Kenneth Choon Meng, Thong, Shu Hua, Kwa, Andrea Lay-Hoon, Ostrowski, Adam, Aung, Thet Tun, Halimah Razali, Low, Shermaine W. Y., Bhattacharyya, Mani Shankar, Gautam, Hemant K., Lakshminarayanan, Rajamani, Sicheritz-Pontén, Thomas, Clokie, Martha R. J., Moreira, Wilfried, van Steensel, Maurice Adrianus Monique

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Metrics to relate COVID-19 wastewater data to clinical testing dynamics by Xiao, Amy, Wu, Fuqing, Bushman, Mary, Zhang, Jianbo, Imakaev, Maxim, Chai, Peter R., Duvallet, Claire, Endo, Noriko, Erickson, Timothy B., Armas, Federica, Arnold, Brian, Chen, Hongjie, Chandra, Franciscus, Ghaeli, Newsha, Gu, Xiaoqiong, Hanage, William P., Lee, Wei Lin, Matus, Mariana, McElroy, Kyle A., Moniz, Katya, Rhode, Steven F., Thompson, Janelle, Alm, Eric J.

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Identifying primary care clinicians' preferences for, barriers to, and facilitators of information-seeking in clinical practice in Singapore: a qualitative study by Lee, Mauricette Moling, Tang, Wern Ee, Smith, Helen Elizabeth, Car, Lorainne Tudor

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Asymmetric synthesis of N-benzyl-5-methylhydroxy-piperidone and modular synthesis of C1-substituent tetrahydroisoquinolines (THIQ) and C2-symmetric bisisoquinolines (C2-BIQ) and th... by Khong, Duc Thinh

“…To the best of our knowledge, this is the first diastereoselective approach towards the synthesis tetrahydroisoquinoline amino alcohol with tunable substituent group at C1. Application of these THIQs and C2-BIQs as chiral ligands in the Cu(II)-catalyzed asymmetric Henry reaction was also investigated. …”
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