Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives by Rabadà, Yvette, Bosch-Sanz, Oriol, Biarnés, Xevi, Pedreño, Javier, Caveda, Luis, Sánchez-García, David, Martorell, Jordi, Balcells, Mercedes

“…Two of the molecules of this family have shown activity that is greater than or similar to that of tranexamic acid (TXA), the current antifibrinolytic gold standard, which has been associated with several side effects and whose use is limited in patients with renal impairment. …”
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Accumulated decoupled learning with gradient staleness mitigation for convolutional neural networks by Zhuang, Huiping, Weng, Zhenyu, Luo, Fulin, Toh, Kar-Ann, Li, Haizhou, Lin, Zhiping

“…Gradient staleness is a major side effect in decoupled learning when training convolutional neural networks asynchronously. …”
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Efgartigimod efficacy and safety in refractory myasthenia gravis: UK’s first real-world experience by Moniz Dionísio, J, Ambrose, P, Burke, G, Farrugia, ME, Garcia-Reitboeck, P, Hewamadduma, C, Hill, M, Howard, RS, Jacob, S, Kullmann, D, Leite, MI, Miller, J, Pinto, A, Pritchard, J, Riswick, T, Sathasivam, S, Thambirajah, N, Viegas, S, Norwood, F, Spillane, J

“…The mean intracycle reduction in the MG-ADL score in the first, second, third and fourth cycles were −4.6 to –3.9, −3.4 and −4.2, respectively. Side effects were generally mild. No rescue treatments were required. …”

Intraday adaptation to extreme temperatures in outdoor activity by Fan, Yichun, Wang, Jianghao, Obradovich, Nick, Zheng, Siqi

“…Such within-day adaptation substantially reduces heat exposure, yet it also delays the active time at night by about half an hour, with potential side effect on sleep quality. Combining empirical estimates with outputs from downscaled climate models, we show that unmitigated climate change will generate sizable activity-depressing and activity-delaying effects in summer when projected on an hourly resolution. …”
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Nuptial journeys: A cultural history of wedding travel in selected Habsburg unions ca 1450–1550 by Pastrnak, P

“…Using the case study of Habsburg trans-European wedding alliances between 1450 to 1550, and drawing upon a significant reservoir of sources, this thesis shows that transfers of princely brides(grooms) were not an inconsequential side effect of weddings but were an ideal channel through which to negotiate the social status of dynasties, serve monarchical splendour and memory, prepare elite individuals for their new role and integrate them into their new environment, interact with foreign individuals and form relationships with them. …”

The adoption, diffusion and impact of an auditing documentation software in a Singapore public accounting firm : a case study by Goh, Lay Hoon, Loy, Heng Heen, Seow, Kuan Yeow

“…The project team found that A+ had a mixed effect on auditor performance and work satisfaction. …”
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The effects of person-environment fit on employees' knowledge contribution by Pee, Loo Geok

“…The PE fit theory accounts for both employee-side and organization-side effects and enriches our conceptual understanding of the antecedents of knowledge contribution. …”
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Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3,3-di(indolyl)indolin-2-ones by Santoso, Mardi, Ong, Li Lin, Aijijiyah, Nur Pasca, Wati, First Ambar, Azminah, Azminah, Annuur, Rose Malina, Fadlan, Arif, Judeh, Zaher M. A.

“…The results suggest that 3,3-di(indolyl)indolin-2-ones may be developed as suitable Alpha Glucosidase Inhibitors (AGIs) and the lower α-amylase activities should be advantageous to reduce the side effects exhibited by commercial AGIs.…”
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Glycosylated copper sulfide nanocrystals for targeted photokilling of bacteria in the near‐infrared II window by Hou, Shuai, Mahadevegowda, Surendra Hittanahalli, Mai, Van Cuong, Chan‐Park, Mary Bee Eng, Duan, Hongwei

“…A targeting strategy is thus required to minimize side effects and enhance the antibacterial efficiency. …”
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In vitro and In vivo photothermal cancer therapeutic effects of gold nanorods modified with mushroom β-glucan by Li, Xiaojie, Zhou, Jiajing, Dong, Xiaonan, Cheng, Wai-Yin, Duan, Hongwei, Cheung, Peter C. K.

“…Intravenous injection of AuNR-Glu nanohybrids followed by irradiation from a NIR-II laser at a safe dose (1.0 W/cm2 for 5 min) in nude mice implanted with HT-29 tumors was effective in significantly reducing the tumor growth, with no obvious harmful side effects, as evidenced by histological analysis of major organs. …”
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Clinical Cost-Effectiveness as a Novel Metric for Steering Emerging Medical Technology by Richards, Daniel Herndon

“…Results: The most sensitive driver of incremental effectiveness of LDD over surgery was, per the model, the potential of LDD to reduce systemic side effects. The potential clinical benefit of LDD over surgery was estimated, probabilistically, as between P10 and P90 values of 0.081 and 0.339 QALYs, respectively. …”
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Complex coacervates loaded with nano enzymes as microreactor by Ng, Si Yi

“…These nanoparticles are able to penetrate tissues and target specific cells due to their small size in nature and reduce potential side effects, improving the overall treatment efficacy. …”
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Diffuse Correlation Spectroscopy (DCS) and Diffuse Optical Spectroscopy (DOS) for photodynamic therapy monitoring. by Siti Raudhah Matyasir.

“…PDT is an emerging modality that has many advantages such as non-invasive, low side effects, low scarring, low risk of resistance, cost effective and shorter treatment time. …”
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Uptake and safety of Sotrovimab for prevention of severe COVID-19 in a cohort and self-controlled case series study by Patone, M, Snelling, AJ, Tibble, H, Coupland, C, Sheikh, A, Hippisley-Cox, J

“…Trials have shown it to have mild to moderate side effects, however, evidence regarding its safety in real-world settings remains insufficient. …”

Low-dose spironolactone and cardiovascular outcomes in moderate stage chronic kidney disease: a randomized controlled trial by Hobbs, FDR, McManus, RJ, Taylor, CJ, Jones, NR, Rahman, JK, Wolstenholme, J, Kim, S, Kwon, J, Jones, L, Hirst, JA, Yu, L-M, Mort, S

“…The most common reason for stopping spironolactone was a decrease in the estimated glomerular filtration rate that met prespecified stop criteria (n = 239, 35.4%), followed by participants being withdrawn due to treatment side effects (n = 128, 18.9%) and hyperkalemia (n = 54, 8.0%). …”

First-in-man study of the PSMA Minibody IR800-IAB2M for molecularly targeted intraoperative fluorescence guidance during radical prostatectomy by Hamdy, FC, Lamb, AD, Tullis, IDC, Verrill, C, Rombach, I, Rao, SR, Colling, R, Barber, PR, Volpi, D, Barbera-Martin, L, Lopez, JF, Omer, A, Hewitt, A, Lovell, S, Niederer, J, Lambert, A, Snoeck, J, Thomson, C, Leslie, T, Bryant, RJ, Mascioni, A, Jia, F, Torgov, M, Wilson, I, Gudas, J, Wu, AM, Olafsen, T, Vojnovic, B

“…Overall sensitivity and specificity in detecting non-lymph-node extra-prostatic cancer tissue were 100% and 65%, and 64% and 64% respectively for lymph node positivity. There were no side-effects associated with administration of the reagent. …”

Ameliorative effect of α-tocopherol and tocotrienol-rich palm oil extract on menopause-associated mood disorder in ovariectomized mice by Liang, Gengfan, Kow, Audrey Siew Foong, Lee, Yu-Zhao, Yusof, Rohana, Tham, Chau Ling, Ho, Yu-Chung, Lee, Ming Tatt

“…The current treatment for menopause-associated mood disorder provides only symptomatic relief and is associated with many side effects. Supplementation with vitamin E has been shown to be effective in ameliorating anxiety and depression. …”
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In vitro and in silico studies of Lawsone on inflammation-induced skin cells for development of skin anti-inflammatory treatment by Abdullah, Shazleen Sofea, Mohammad Latif, Muhammad Alif, Md Tohid, Siti Farah

“…Lawsone, an active phytoconstituent of Lawsonia inermis sp., is proposed as a safer alternative for the current skin anti-inflammatory treatments that are mainly steroidal with unwanted side effects which does not conform to the concept of halalan toyyiban in medicine. …”
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Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…Its favorable biocompatibility, pH sensitivity, and sustained release properties facilitated reduced toxic side effects of 5-FU on NIH3T3 normal cells and enhanced inhibitory effects on CT26 colon cancer cells. …”
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Influence of PODE1 additive into ethanol-gasoline blends (E10) on fuel properties and phase stability by Awad, Omar I., Zhou, Bo, Chen, Zhenbin, Kadirgama, Kumaran, Mohammed, M. N., Devarajan, Ramasamy

“…Additionally, up to 10 % PODE1 additive had no significant side effect on the fuel properties of E10, particularly boiling point and octane number. …”
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