Molecular, Genetic, and Process Approaches for Improving Secreted Pharmaceutical Protein Quality in Komagataella phaffii by Yang, Yuchen

“…Compared to traditional synthetic small-molecule drugs, recombinant therapeutic proteins offer advantages like enhanced specificity and reduced side effects, and there has been tremendous growth in their innovation thanks to modern DNA technologies and AI-driven algorithms. …”
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From Transparency to Accountability and Back by Cen, Sarah, Alur, Rohan

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Simulation methods and tissue property models for non-invasive transcranial focused ultrasound surgery by Connor, Christopher W

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Alleviation of off-target effects from vector-encoded shRNAs via codelivered RNA decoys by Mockenhaupt, Stefan, Grosse, Stefanie, Rupp, Daniel, Bartenschlager, Ralf, Grimm, Dirk

“…However, in principle, the sense strand also possesses silencing capacity that may contribute to adverse RNAi side effects including off-target gene regulation. Here, we address this concern with a novel strategy that reduces sense strand activity of vector-encoded shRNAs via codelivery of inhibitory tough decoy (TuD) RNAs. …”
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The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Combination csDMARDs have shown some superiority over single therapies but there are limited data and concerns about side effects. Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. Conclusion: Our study underscores the critical importance of community-based screening in detecting undiagnosed hypertension. …”

Anti-ageing properties of edible bird's nest ascertained by in vitro and in vivo studies in animal model by Hou, Zhiping

“…Hormone replacement therapy (HRT) has been used to restore postmenopausal hormonal levels in order to relieve menopausal problems, but its associated side effects including development of cancers and cardiovascular diseases have necessitated the search for other alternatives such as natural food supplementation. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Virtual reality as a countermeasure for astronaut motion sickness during simulated post-flight water landings by Lonner, T. L., Allred, A. R., Bonarrigo, L., Gopinath, A., Smith, K., Kravets, V., Groen, E. L., Oman, C., DiZio, P., Lawson, B. D., Clark, T. K.

“…Anticholinergic pharmaceuticals (e.g., Meclizine) are often taken prior to landing; however, they have operationally adverse side effects (e.g., drowsiness). There is a need to develop non-pharmaceutical countermeasures to EMS. …”
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The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis by Singh, S, Boyd, S, Schilling, WHK, Watson, JA, Mukaka, M, White, NJ

“…The relationship between the clinical and virological treatment effects was assessed by mixed-effects meta-regression.</p> <p><strong>Results:&nbsp;</strong>From 57 potentially eligible RCTs, VCRRs were derived for 44 (52 384 participants); 32 had &ge;1 clinical endpoint in each arm. …”

Sudden gains in internet cognitive therapy for social anxiety disorder in routine clinical practice by Yim, SH, Clark, DM, Salkovskis, PM, Thew, GR

“…Of 193 treated patients, 146 provided sufficient data to permit analysis. Linear mixed effects models were used to examine the impact of sudden gains on clinical outcomes, and examine changes in negative social cognitions, self-focused attention, and depressed mood.…”

Testing the effect of ecolabels on the environmental impact of food purchases in worksite cafeterias: a randomised controlled trial by Luick, M, Stewart, C, Clark, M, Bateman, P, Biggs, E, Cook, B, Little, M, Wren, GM, Jebb, SA, Pechey, R

“…The mean weekly environmental impact scores of hot meal options over the full 12-week trial period were assessed using hierarchical mixed effects models. Results: There was no significant effect of the intervention on the environmental impact scores of meals sold (mean difference between control and intervention sites: -1.4%, 95%CI: -33.6%, + 30.8%). …”

A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures by Morrill Gavarró, L, Couturier, D, Markowetz, F

“…Results: We propose a mixed-effects Dirichlet-multinomial model: within-patient correlations are taken into account with random effects, possible correlations between signatures by making such random effects multivariate, and a group-specific dispersion parameter can deal with particularities of the groups. …”

Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Medical chemists still have many challenges because of the high side effects, increasing tumor resistance, and low selectivity of new chemotherapeutic medications despite the enormous effort put out to extract, develop, and synthesize them. …”
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Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

“…Systemic injection of most cytokines has only shown modest clinical benefits, while associated with significant side-effects akin to chronic inflammation. Local, targeted delivery of cytokines in tumour sites is beneficial to achieve high therapeutic dose within tumour while limiting systemic dose. …”
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Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…Combination therapies that exploit different ways to treat cancer cells, while minimising adverse side-effects, have gained increased traction in recent years. …”

Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Oral squamous cell carcinoma (OSCC), a major oral cancer, significantly challenges treatments and impacts patient quality of life; current therapies often cause severe side effects, highlighting the urgent need for gentler alternatives. …”
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Unexpected anthropogenic emission decreases explain recent atmospheric mercury concentration declines by Feinberg, Aryeh, Selin, Noelle E., Braban, Christine F., Chang, Kai-Lan, Custódio, Danilo, Jaffe, Daniel A., Kyllönen, Katriina, Landis, Matthew S., Leeson, Sarah R., Luke, Winston, Molepo, Koketso M., Murovec, Marijana, Nerentorp Mastromonaco, Michelle G., Aspmo Pfaffhuber, Katrine, Rüdiger, Julian, Sheu, Guey-Rong, St. Louis, Vincent L.

“…Here, we assess the observed trends in gaseous elemental mercury (Hg0) in the NH and apply biogeochemical box modeling and chemical transport modeling to understand the trend drivers. Using linear mixed effects modeling of observational data from 51 stations, we find negative Hg0 trends in most NH regions, with an overall trend for 2005 to 2020 of −0.011 ± 0.006 ng m−3 y−1 (±2 SD). …”
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Formulation and in-vitro release study of drug loaded liposomes for treating dry eye disease by Chua, Yan Ni

“…In addition, there is a need to also ensure a controlled release of drug in order to minimise drug toxicity which may lead to side effects in the body. In this project, we will be reporting the use of liposomal drug delivery system, to encapsulate the hydrophobic drug (Senicapoc) in its hydrophobic bilayer and aim to administer this formulation as an eye drop for the management of Dry Eye Disease (DED). …”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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