Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…Combination therapies that exploit different ways to treat cancer cells, while minimising adverse side-effects, have gained increased traction in recent years. …”

Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Oral squamous cell carcinoma (OSCC), a major oral cancer, significantly challenges treatments and impacts patient quality of life; current therapies often cause severe side effects, highlighting the urgent need for gentler alternatives. …”
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Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis by von Mässenhausen, Anne, Schlecht, Marlena Nastassja, Beer, Kristina, Maremonti, Francesca, Tonnus, Wulf, Belavgeni, Alexia, Gavali, Shubhangi, Flade, Karolin, Riley, Joel S., Zamora Gonzalez, Nadia, Brucker, Anne, Becker, Jorunn Naila, Tmava, Mirela, Meyer, Claudia, Peitzsch, Mirko, Hugo, Christian, Gembardt, Florian, Angeli, Jose Pedro Friedmann, Bornstein, Stefan R., Tait, Stephen W. G., Linkermann, Andreas

“…Finally, as ferroptosis contributes to a variety of pathophysiological processes, we cannot exclude side effects in human siRNA-based therapeutical concepts that should be clinically tested.…”
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Hospitalised patients as stewards of their own antibiotic therapy: a qualitative analysis informing the strategic design of interventions to encourage shared decision-making in ter... by Guo, Huiling, Lye, David C., Ng, Tat Ming, Somani, Jyoti, Kwa, Andrea Lay Hoon, Chung, Jasmine Shimin, Chow, Angela

“…Highlighting potential side effects of antibiotics could motivate them to ask questions about their antibiotic therapies. …”
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Formulation and in-vitro release study of drug loaded liposomes for treating dry eye disease by Chua, Yan Ni

“…In addition, there is a need to also ensure a controlled release of drug in order to minimise drug toxicity which may lead to side effects in the body. In this project, we will be reporting the use of liposomal drug delivery system, to encapsulate the hydrophobic drug (Senicapoc) in its hydrophobic bilayer and aim to administer this formulation as an eye drop for the management of Dry Eye Disease (DED). …”
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Phytochemical analysis and cytotoxic effects of mango (Mangifera indica L) kernel on breast cancer cell lines by Abdullah, Al-Shwyeh Hussah

“…These findings suggest that M. indica kernel extract, with antiproliferative properties towards cancer cells, while relatively innocuous to normal cells, is a good candidate as an alternative to or for supplementation for current chemotherapies in the treatment of breast cancers, without showing the side-effects associated with these anticancer drugs.…”
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"Meta-atomless" architecture based on an irregular continuous fabric of coupling-tuned identical nanopillars enables highly efficient and achromatic metasurfaces by Yaǧcl, H. Bilge, Demir, Hilmi Volkan

“…However, to date, a pending and fundamental problem of this approach has been the low device efficiency that such resulting metasurface components suffer, an unwanted side effect of large lattice constants that are used for preventing intercoupling of their meta-atoms. …”
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Design, synthesis, structural characterization, cytotoxicity and computational studies of Usnic acid derivative as potential anti-breast cancer agent against MCF7 and T47D cell lin... by Roney, Miah, Wong, Kelvin Khai Voon, Uddin, Md. Nazim, Rullah, Kamal, Septama, Abdi Wira, Antika, Lucia Dwi, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Development of novel inhibitors is necessary to counteract the rising prevalence of breast cancer (BC) in women in recent years, as evidenced by the side-effect profiles of a few clinically approved inhibitors. …”
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Effects of ifenprodil treatment on pain behaviour, inflammation, and nociceptive responses in the spinal cord of complete freund’s adjuvant-induced chronic polyarthritis rat by Noh, Ain’ Sabreena Mohd

“…This study aimed to investigate the effect of Ifenprodil as a selective NMDAR-2B antagonist on pain behaviour, inflammation, and nociceptive responses in the spinal cord of CFA-induced polyarthritis, as well as its possible side effect on memory function. Arthritic rats received intrathecal treatment of either Ifenprodil (0.5 or 1.0 μg/μL) or Sodium Diclofenac (6 μg) (positive control) whereas arthritic (A) and non-arthritic (C) control groups were administered with 0.9% normal saline for 7 days (day-16 to -22 post-arthritic induction). …”
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Formulation, optimization and characterization of palm kernel oil esters nanoemulsion system containing sodium diclofenac by Rezaee, Malahat

“…Transdermal administration is a suitable route for sodium diclofenac to prevent its adverse side effects which exhibited in other routes. Palm kernel oil esters (PKOEs) were selected as the oil phase for the preparation of nanoemulsion formulations containing sodium diclofenac. …”
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Thermal-disrupting interface mitigates intercellular cohesion loss for accurate topical antibacterial therapy by Hu, Benhui, Berkey, Christopher, Feliciano, Timothy, Chen, Xiaohong, Li, Zhuyun, Chen, Chao, Amini, Shahrouz, Nai, Mui Hoon, Lei, Qun-Li, Ni, Ran, Wang, Juan, Leow, Wan Ru, Pan, Shaowu, Li, Yong-Qiang, Cai, Pingqiang, Miserez, Ali, Li, Shuzhou, Lim, Chwee Teck, Wu, Yun-Long, Odom, Teri W., Dauskardt, Reinhold H., Chen, Xiaodong

“…Finally, endowing wound dressing with the TRIM effect via in vivo studies in S. aureus infected mice demonstrates a promising strategy for mitigating the side effects of photothermal therapy against a wide spectrum of bacterial infections, promoting future biointerface design for antibacterial therapy.…”
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Translated and culturally adapted internet-delivered cognitive therapy for social anxiety disorder in Japanese clinical settings: study protocol for a randomised controlled trial by Yoshinaga, N, Thew, G, Hayashi, Y, Tanoue, H, Nakai, M, Clark, DM

“…The primary analyses will be conducted on an intent-to-treat basis, comparing the primary and secondary outcome measures between groups using linear mixed-effect models, along with additional mediation analysis. …”

Mujeres a la fuga: narrativa del viaje como vehículo de resistencia para las mujeres en tránsito por México = Women on the run: narrative of the journey as a vehicle of resistance... by López, María E., Díaz de León, Alejandra, Castro Sam, Ana Sabina

“…Despite the growing literature on the dangers faced by migrant women and children in transit through Mexico, the authorities and much of the academic community continue to treat migrant women as passive subjects and the specific violence they face in Mexico as a side effect of other problems in the country related to the increasing activity of organized crime. …”
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Robotic assisted upper limb training post stroke : a randomized control trial using combinatory approach toward reducing workforce demands by Budhota, Aamani, Chua, Karen S. G., Hussain, Asif, Kager, Simone, Cherpin, Adèle, Contu, Sara, Vishwanath, Deshmukh, Kuah, Christopher W. K., Ng, Chwee Yin, Yam, Lester H. L., Loh, Yong Joo, Rajeswaran, Deshan Kumar, Xiang, Liming, Burdet, Etienne, Campolo, Domenico

“…There were no training-related adverse side effects. In conclusion, time matched combinatory training incorporating H-Man RAT produced similar outcomes compared to conventional therapy alone. …”
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Synthesis and characterization of reduced graphene oxide-based composites by Wu, Shixin

“…The amount of chlorine precursor (CuCl2) in the electrolyte has two-sided effects on the doping of Cl-Cu2O/rGO composites as it determines donor concentration and simultaneously affects the surface coverage of Cu2O crystals on the rGO electrode. …”
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Variable selection in parametric and semiparametric models by Lin, Bingqing

“…There are relatively less papers discussing model selection problems in some special but important parametric and semiparametric models, such as linear mixed-effects model, partially varying-coefficient single-index model and single-index-coefficient regression model. …”
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Relative importance of soil properties and functional diversity to the spatial pattern of the forest soil nitrogen by Kang, Jian, Deng, Zebang, Zhang, Zhongrui, Chen, Shuilian, Huang, Jianguo, Ding, Xiaogang

“…However, few studies have investigated the factors influencing SN. The linear mixing effect and generalized additivity model were used to investigate the spatial patterns and influencing factors of SN by collecting and measuring the total nitrogen content of forest soil samples in the middle and lower reaches of the Xijiang River Basin (XRB). …”
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The relationship between viral clearance rates and disease progression in early symptomatic COVID-19: a systematic review and meta-regression analysis by Singh, S, Boyd, S, Schilling, WHK, Watson, JA, Mukaka, M, White, NJ

“…The relationship between the clinical and virological treatment effects was assessed by mixed-effects meta-regression.</p> <p><strong>Results:&nbsp;</strong>From 57 potentially eligible RCTs, VCRRs were derived for 44 (52 384 participants); 32 had &ge;1 clinical endpoint in each arm. …”

Sudden gains in internet cognitive therapy for social anxiety disorder in routine clinical practice by Yim, SH, Clark, DM, Salkovskis, PM, Thew, GR

“…Of 193 treated patients, 146 provided sufficient data to permit analysis. Linear mixed effects models were used to examine the impact of sudden gains on clinical outcomes, and examine changes in negative social cognitions, self-focused attention, and depressed mood.…”

Testing the effect of ecolabels on the environmental impact of food purchases in worksite cafeterias: a randomised controlled trial by Luick, M, Stewart, C, Clark, M, Bateman, P, Biggs, E, Cook, B, Little, M, Wren, GM, Jebb, SA, Pechey, R

“…The mean weekly environmental impact scores of hot meal options over the full 12-week trial period were assessed using hierarchical mixed effects models. Results: There was no significant effect of the intervention on the environmental impact scores of meals sold (mean difference between control and intervention sites: -1.4%, 95%CI: -33.6%, + 30.8%). …”