The protocol of a clinical effectiveness trial comparing standard step-up care, early combination DMARD therapy and early use of TNF inhibitors for the treatment of moderate to sev... by Watson, M, Tillett, W, Jadon, D, Massa, MS, Francis, A, Gullick, N, Rombach, I, Sinomati, Y, Tucker, L, Coates, LC

“…Combination csDMARDs have shown some superiority over single therapies but there are limited data and concerns about side effects. Early use of biologics has also been shown to be superior to methotrexate but these drugs are costly and not usually funded first line. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. Conclusion: Our study underscores the critical importance of community-based screening in detecting undiagnosed hypertension. …”

Anti-ageing properties of edible bird's nest ascertained by in vitro and in vivo studies in animal model by Hou, Zhiping

“…Hormone replacement therapy (HRT) has been used to restore postmenopausal hormonal levels in order to relieve menopausal problems, but its associated side effects including development of cancers and cardiovascular diseases have necessitated the search for other alternatives such as natural food supplementation. …”
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Design, fabrication and characterization of a tunnel FET by Chen, Zhixian.

“…This report details and demonstrates a vertical silicon nanowire (SiNW) based tunneling field-effect transistor (TFET) using CMOS compatible technology. …”
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Ohmic contact formation to β-Ga2O3 nanosheet transistors with Ar-containing plasma treatment by Chen, Jinxin, Liu, Bingyan, Gu, Yang, Li, Bin

“…With the optimal plasma pre-treatment (i.e., Ar plasma, 100 W, 60 s), the resulting β-Ga2O3 nanosheet field-effect transistors (FETs) show effective Ohmic contact (i.e., contact resistance RC of 104 Ω·mm) without any post-annealing, which leads to competitive device performance such as a high current on/off ratio (>107), a low subthreshold swing (SS, 249 mV/dec), and acceptable field-effect mobility ((Formula presented.), ~21.73 cm2 V−1 s−1). …”
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Design, characterization and properties of nitrogen-containing novel organic N-type materials by Wu, Yuechao.

“…In past decades,organic semiconductors have caused a lot of interests because of their potential applications in field-effect transistors(FET),organic-light-emitting devices(OLED)and photovoltaic cells.Among them,developing high-efficient n-type organic materials for organic field-effect transistors(OFETs)is very urgent.Currently, p-type organic semiconductors are well-developed and their mobility can go as high as4.8 cm2V-1S-1.Since p-type and n-type materials are equally important for the fabrication of p-n junctions and complementary logic circuits,the demand to find the promising n-type counterparts is necessary. …”
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Part I : Peptide functionalized materials for gram-negative bacteria targeted PDT and LPS sensing. Part II : Small peptide and membrane lipid based self-assembled nanostructures fo... by Liu, Fang

“…Generally, Gram-negative bacterial pathogens have additional outer membranes mainly composed of highly conserved and unique lipopolysaccharide (LPS) molecules, which serve as permeability barriers to prevent the cell bodies from toxic antimicrobial molecules1-2 including many photosensitizers, which have been successfully used in photoinactivation of Gram-positive strains.3-4 Furthermore, LPS, a potent inducer to human innate immune systems, hence called endotoxin, is now primarily responsible for sepsis associated with the infections of Gram-negative pethogens.5-6 Therefore, the most promising strategy is use of LPS neutralizing peptide as the binding ligand to deliver antibacterial agents meanwhile minimize the side effects.7 The first objective of the research in part I is the design and synthesis of photosensitizer-peptide conjugates for multivalent targeted cellular imaging and photodynamic inactivation (PDI) against Gram-negative bacterial strains. …”
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Effects of a participatory-art based intervention on holistic health outcomes of Singapore older community dwellers: the Singapore a-health study by Ho, Reen Wan Li

“…Intervention group participants were hypothesised to experience unique improvements in frailty, wellbeing and quality of life over the 12 weeks. Linear mixed-effect models did not find quantitative evidence for intervention effects, though a thematic analysis uncovered four themes pointing to benefits of the intervention: promoting cognitive stimulation, enhancing perceived self-efficacy, enabling social involvement and fostering art appreciation. …”
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Improved effective channel length extraction method for 0.09-0.13 mm CMOS by Eng, Chee Wee

“…In fact, an original and new method of Leff extraction has been developed through the discovery of new device physics for state-of-the-art metal-oxide-semiconductor field-effect-transistors (MOSFETs) with ultra-thin gate oxide (? …”
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Helicobacter pylori infection can affect energy modulating hormones and body weight in germ free mice by Loke, Mun Fai, Vadivelu, Jamuna, Tan, Tuan Lin, Wong, Whye Yen, Khosravi, Yalda, Seow, Shih Wee, Amoyo, Arlaine Anne, Chiow, Kher Hsin, Poh, Qian Hui, Sentosa, Ignatius Mario Doli, Bunte, Ralph M., Pettersson, Sven

“…Further investigations of possible additional side effects of H. pylori are highly warranted.…”
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Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases by Baek, Jong-Suep, Yeo, Eng Wan, Lee, Yin Hao, Tan, Nguan Soon, Loo, Say Chye Joachim

“…Therefore, this delivery system is a promising platform to control the delivery of NSAIDs to combat inflammatory diseases, thereby protecting against possible gastrointestinal side effects that may arise from the overuse of NSAIDs.…”
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Virtual reality as a countermeasure for astronaut motion sickness during simulated post-flight water landings by Lonner, T. L., Allred, A. R., Bonarrigo, L., Gopinath, A., Smith, K., Kravets, V., Groen, E. L., Oman, C., DiZio, P., Lawson, B. D., Clark, T. K.

“…Anticholinergic pharmaceuticals (e.g., Meclizine) are often taken prior to landing; however, they have operationally adverse side effects (e.g., drowsiness). There is a need to develop non-pharmaceutical countermeasures to EMS. …”
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Identification of potent new brain cancer EGFR inhibitor from usimine A and usimine B: computer-aided drug design perspective by Roney, Miah, Issahaku, Abdul Rashid, Wilhelm, Anke, Mohd Fadhlizil Fasihi, Mohd Aluwi

“…Medical chemists still have many challenges because of the high side effects, increasing tumor resistance, and low selectivity of new chemotherapeutic medications despite the enormous effort put out to extract, develop, and synthesize them. …”
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Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

“…Systemic injection of most cytokines has only shown modest clinical benefits, while associated with significant side-effects akin to chronic inflammation. Local, targeted delivery of cytokines in tumour sites is beneficial to achieve high therapeutic dose within tumour while limiting systemic dose. …”
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Investigating the impact of growth arrest mechanisms on tumour growth and responses to radiotherapy and hyperthermia by Colson, C

“…Combination therapies that exploit different ways to treat cancer cells, while minimising adverse side-effects, have gained increased traction in recent years. …”

Cytotoxic effect of Bajong LN rice methanol extract on human squamous cell Carcinoma, ORL-48 by Vivi Noryati Ahmad, Nur Aliana Hidayah Mohamed, Zulkhairi Amom, Khor, Goot Heah, Nurhayati Mohamad Zain, Indah Mohd Amin

“…Oral squamous cell carcinoma (OSCC), a major oral cancer, significantly challenges treatments and impacts patient quality of life; current therapies often cause severe side effects, highlighting the urgent need for gentler alternatives. …”
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Treatment with siRNAs is commonly associated with GPX4 up-regulation and target knockdown-independent sensitization to ferroptosis by von Mässenhausen, Anne, Schlecht, Marlena Nastassja, Beer, Kristina, Maremonti, Francesca, Tonnus, Wulf, Belavgeni, Alexia, Gavali, Shubhangi, Flade, Karolin, Riley, Joel S., Zamora Gonzalez, Nadia, Brucker, Anne, Becker, Jorunn Naila, Tmava, Mirela, Meyer, Claudia, Peitzsch, Mirko, Hugo, Christian, Gembardt, Florian, Angeli, Jose Pedro Friedmann, Bornstein, Stefan R., Tait, Stephen W. G., Linkermann, Andreas

“…Finally, as ferroptosis contributes to a variety of pathophysiological processes, we cannot exclude side effects in human siRNA-based therapeutical concepts that should be clinically tested.…”
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Hospitalised patients as stewards of their own antibiotic therapy: a qualitative analysis informing the strategic design of interventions to encourage shared decision-making in ter... by Guo, Huiling, Lye, David C., Ng, Tat Ming, Somani, Jyoti, Kwa, Andrea Lay Hoon, Chung, Jasmine Shimin, Chow, Angela

“…Highlighting potential side effects of antibiotics could motivate them to ask questions about their antibiotic therapies. …”
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The characterization of reflectin protonic conductivity by Reyes, Jacob

“…Through hydration and swelling/deswelling of thin-film layers of these reflectin proteins, this study’s main focus is to explore the optical and electrical properties of SlRF-B1 thin films. Field-Effect Transistor devices were also constructed to test whether colour change within SlRF-B1 thin films could be induced electrically, thereby paving way for further research into eco-friendly biophotonic devices and coatings.…”
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Development of optical transceiver by Sim, Sebastian Shih Wei.

“…The characterization of the photodiode and the Metal Oxide Semiconductor Field Effect Transistor (MOSFET) structures will be performed using the apparatus in the Nanophotonic Laboratory. …”
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