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    Nuclei sorting-based genome-wide CRISPR screens to identify novel regulators of hepatic insulin signalling by Martin Perez, E

    Published 2024
    “…Amongst the top differentially enriched genes were binding partners TMED2 and TMED10. I carried out validation and mechanistic studies that confirmed that loss of TMED2 and TMED10 results in nuclear FoxO1-Clover retention following insulin treatment, as well as aberrant AKT phosphorylation. …”
    Thesis