Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Fernandez, LG, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, SR, Patil, KD, Gairola, S, Dunachie, S, Merchant, HA, Stokes, R, Kuwana, R, Maes, A, Charrier, J, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, PN, Zitzmann, N, Gangadharan, B

“…Furthermore, even if a falsified product contained polysorbate 80 at the same concentration as used in the genuine vaccine, the characteristic spectral profile of polysorbate 80 used in genuine products is a reliable internal marker for vaccine authenticity. Our findings demonstrate that MALDI-ToF MS analysis of extracts from vial labels and the vaccine excipients themselves can be used independently to detect falsified vaccines. …”

Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model by Emmerson, JT, Do Carmo, S, Lavagna, A, Huang, C, Wong, TP, Martinez-Trujillo, JC, Cuello, AC

“…As anticipated, at more advanced stages, the APPxhTau bigenic rats exhibited aggravated tau and amyloid pathologies, cognitive decline, increased neuroinflammation, and tau-driven neuronal loss compared to monogenic rat models of Alzheimer’s-like amyloid and tau pathologies. The present findings propose that the early accumulation of phosphorylated tau may have a transient protective impact on the evolving amyloid pathology-derived synaptic impairments.…”

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Marques, IF, Domènech-Panicello, C, Geurtsen, ML, Hoang, TT, Richmond, R, Polinski, K, Sirignano, L, Page, CM, Binter, A, Everson, T, Burt, A, Deuschle, M, Gilles, M, Streit, F, Mumford, SL, Magnus, P, Reiss, IKM, Vermeulen, MJ, Witt, SH, Chaves, I, Yeung, E, London, SJ, Guxens, M, Felix, JF

“…Conclusion: Maternal night shift work during pregnancy was associated with newborn DNA methylation at 3 CpGs. Top findings overlapped with those in a mouse model of gestational jet lag. …”

Molecular mechanisms relevant to the maintenance of locomotor control by Guo, F

“…Excitingly, this significantly rescued the hyperlocomotor phenotype of the <em>Trkb</em>^PENK-KO mice. These findings add knowledge to the molecular mechanisms underlying normal locomotor maintenance, and they also highlight related pathway as a potential target for the development of novel treatments to movement disorders.…”

Myocardial ischaemia following COVID-19: a cardiovascular magnetic resonance study by Arnold, JR, Yeo, JL, Budgeon, CA, Shergill, S, England, R, Shiwani, H, Artico, J, Moon, JC, Gorecka, M, Roditi, G, Morrow, A, Mangion, K, Shanmuganathan, M, Miller, CA, Chiribiri, A, Alzahir, M, Ramirez, S, Lin, A, Swoboda, PP, McDiarmid, AK, Sykes, R, Singh, T, Bucciarelli-Ducci, C, Dawson, D

“…Myocardial ischaemia was present in ~ 20% of patients recently hospitalised with COVID-19 and with elevated cardiac troponin, but this was not different to matched comorbid controls. This finding coupled with the lack of an association between ischaemia and myocardial scar suggests that coronary artery abnormalities are unlikely to be the predominant mechanism underlying COVID-19 induced myocardial injury. …”

Plasma trimethylamine N-oxide (TMAO): associations with cognition, neuroimaging, and dementia by Yaqub, A, Vojinovic, D, Vernooij, MW, Slagboom, PE, Ghanbari, M, Beekman, M, van der Grond, J, Hankemeier, T, van Duijn, CM, Ikram, MA, Ahmad, S

“…<p><b>Conclusions</b></p> Plasma choline, as opposed to TMAO, was found to be associated with cognitive decline, brain atrophy, and markers of cerebral small vessel disease. These findings illustrate the complexity of relationships between TMAO and its precursors, and emphasize the need for concurrent study to elucidate gut-brain mechanisms.…”

Effectiveness and safety of COVID-19 vaccination in people with blood cancer by Copland, E, Hirst, J, Mi, E, Patone, M, Chen, D, Coupland, C, Hippisley-Cox, J

“…</p> <br> <p><strong>Findings:</strong> The cohort comprised 12,274,948 individuals, of whom 81,793 had blood cancer. …”

An aerodynamic investigation of a high-pressure turbine using rotor casing static pressure measurements at engine representative conditions with different tip designs, tip gaps, an... by Singh, D, Beard, PF, Cardwell, D, Staelens, V, Bahulekar, P, Stokes, M, Bather, S, Chana, K

“…However, the majority of the present findings are based on linear cascade or low-speed rotational studies, due to the high cost of the experiments and difficulty in instrumentation at engine conditions. …”

Maternal postpartum six-week check and short-term health outcomes for women with hypertensive disorders in pregnancy: an observational study using the Clinical Practice Research Da... by Ramakrishnan, R, Korb, D, Li, Y, Knight, M, Carson, C

“…</p> <br> <p><strong>Conclusions:</strong> There may be missed opportunities in postpartum care among women with HDP. Our findings highlight the need to ensure that general postpartum care is not overlooked in women with specific morbidities in pregnancy.…”

Functional characterisation of multiple sclerosis-­associated single nucleotide polymorphisms in the Eomesodermin region by Leach, O

“…Despite observing significant differences in expression between genotype groups in a pilot study, findings in a larger cohort did not reach the threshold for significance. …”

The effects of angiotensin-receptor blockade on mood and vigilance behaviour in a gamified foraging task by Morse, L

“…Additionally, we replicated the finding that task environment impacts mood ratings and suggest this task may therefore be useful for investigating mood in future studies.…”

International healthcare workers’ experiences and perceptions of the 2022 multi-country mpox outbreak by Apea, V, Titanji, BK, Dakin, FH, Hayes, R, Smuk, M, Kawu, H, Waters, L, Levy, I, Kuritzkes, DR, Gandhi, M, Rockstroh, J, Schechter, M, Holt, M, Palich, R, Cortes, CP, Nozza, S, Mussini, C, Calmy, A, Crabtree-Ramirez, BE, Blanco, JL, Bhagani, S, Dewsnap, C, Orkin, C, On Behalf of the Mpox SHARE-NET Writing Group

“…Where offered, there were high levels of uptake across all regions. The findings highlight a critical need for addressing the profound gaps in HCW knowledge about re-emerging diseases with pandemic potential. …”

Key transcriptional regulators of neutrophil function in inflammation by Ai, Z

“…KLF6 and RUNX1 deficient neutrophils also displayed impaired transmigration properties. Consistent with findings in the Hoxb8 in vitro model, conditional deletion of RUNX1 in myeloid populations produced lower mature neutrophils in the bone marrow.…”

Participation and cooperation in global climate governance by Rowan, SS

“…Second, patterns of participation are associated with the ambition of countries’ greenhouse gas mitigation targets in the Paris Agreement. These findings help illuminate debates about how states use dense institutional environments, why states join institutions, and the depth of cooperation.…”

Molecular and physiological consequences of prematurity and blood pressure elevation on the young adult left ventricular stress response by Huckstep, O

“…Collectively, these findings suggest preterm-born young adults have reduced myocardial functional reserve which likely contributes to risk of future disease including heart failure. …”

Techniques for analysis and integration of histology data and agent-based modelling of T cell-tumour interactions by Stephens, R

“…In the final part of the thesis we develop a new on-lattice ABM which builds on the findings of our first model, and use it to identify conditions under which spatial statistics enable us to make earlier and more accurate predictions of tumour responses to immunotherapy.…”

Accessibility, inclusivity, and implementation of COVID-19 clinical management guidelines early in the pandemic: a global survey by Pilbeam, C, Malden, D, Newell, K, Dagens, A, Kennon, K, Michelen, M, Gobat, N, Sigfrid, L

“…<br><strong> Conclusion: </strong>Our findings highlight important gaps in COVID-19 CMG development and implementation challenges during a pandemic, particularly affecting at-risk populations and lower resourced settings. …”

Performance and validation of a digital memory test across the Alzheimer’s disease continuum by Toniolo, S, Attaallah, B, Maio, MR, Tabi, YA, Slavkova, E, Klar, VS, Saleh, Y, Idris, MI, Turner, V, Preul, C, Srowig, A, Butler, C, Thompson, S, Manohar, SG, Finke, K, Husain, M

“…Memory imprecision was able to predict cognitive decline on standard cognitive tests over one year. Overall, these findings show how it might be possible to use a digital memory test in clinics and clinical trial contexts to stratify and track performance across the Alzheimer’s disease continuum.…”

Foreign language learning in the age of the internet: A comparison of informal acquirers and traditional classroom learners in central Brazil by Cole, J

“…The evidence suggests this type of motivation, significantly more associated with FASILs than CTLs, led users to engage deeply with the linguistic details of informal sources.</p> <p>The findings challenge dominant paradigms in several fields of SLA which prioritize expert regulation over independent discovery and controlled, collaborative environments over real-world contexts of use entered into for personal reasons.…”

Characterization of ubiquitin-activated DNA-protein crosslink repair in vitro by Zhu, X

“…</p> <p><strong><em>Conclusion:</em></strong> Our study has demonstrated that ubiquitination of the DPC substrates is a key pathway in regulating SPRTN activity. These findings will not only contribute to the understanding of the mechanisms by which SPRTN proteolysis in DPCs repair, but also provide a powerful <em>in vitro</em> approach for drug screening to develop new cancer treatment strategies.…”