Tumor cell-intrinsic signals promoting tolerance and adaptation to oncogenic kinase inhibition by Flower, Cameron Timothy

“…However, many patients still fail to show a clinically meaningful response to kinase inhibitors prescribed on the basis of tumor genotype, and nearly all responsive patients eventually develop resistance, limiting the curative potential of these agents. …”
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Tumor-targeted nano-assemblies for energy-blocking cocktail therapy in cancer by Chen, Manling, Liu, Yidu, Li, Yang, Liu, Xue

“…In human lung tumor cells, the half-maximal inhibitory concentration (IC50) of 2-DG@MA-dots was significantly lower than that of either metformin or 2-DG alone, showing a nearly 100-fold and 30-fold reduction in IC50 values to 11.78 µg mL-1, from 1159 µg mL-1 and 351.20 µg mL-1, respectively. …”
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Investigation of Synthetic Proteins Produced via Automated Fast-Flow Peptide Synthesis by Cowfer, Amanda Elizabeth

“…Since the introduction of solid phase peptide synthesis (SPPS), the peptide community has endeavored to combine the convenience of flow chemistry with the iterative steps associated with peptide elongation in SPPS. Nearly one decade ago, members of the Pentelute lab envisioned and developed a flow-based peptide synthesizer, the Automated Fast-Flow Peptide Synthesizer, or AFPS for short. …”
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Macrobrachium rosenbergii De Man nodavirus recombinant capsid protein production and its interactions with RNA by Goh, Zee Hong

“…Macrobrachium rosenbergii nodavirus (MrNv) is a causative agent of white tail disease (WTD) causing nearly 100% mortality in post-larvae of giant freshwater prawns. …”
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Effectiveness of clinician client-centered counseling on knowledge, attitudes and sexual bahaviors of antiretroviral therapy patients in Yola, Nigeria by Martins, Olutayo Folashade

“…An estimated 34.0 million people are living with HIV/AIDS globally. Nearly one in twenty adults (4.9%) are living with HIV in Sub- Saharan Africa accounting for about 69% of the global burden. …”
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A cross-layer payload-dropping scheme for improving CSMA/CA throughput in interference-limited co-channel cells by Jayabal, Raymond J.

“…For transceivers which do not support CST, PD-CSMA/CA adequately mitigates the exposed node problem, thereby allowing nodes to enjoy nearly the maximum throughput as provided by CSMA/CA in the single cell scenario. …”
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Optimized GPU algorithms for sparse data problems by Pham, Nguyen Quang Anh

“…Our SpGEMM algorithm efficiently enumerates all the work done during a computation to achieve perfect load balancing, and also uses a randomized algorithm to nearly optimally partition the matrix into pieces small enough to be operated on using the fast but limited amount of shared memory. …”
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Maternal Death Surveillance and Response in Sudan: an evidence-based, context-specific optimisation to improve maternal care by Altijani Osman Abbakar, N

“…Analysis of the latest SHHS showed that village and community midwives [trained birth attendants] attended nearly half of all births [55.5%], followed by doctors, health visitors, and nurse-midwives [skilled birth attendants] [22.8%], and the remainder [21.7%] were not attended by a health provider. …”

Genetic analysis of normal human phenotypes within the people of the British Isles by Meena, D

“…For normal hair pigmentation, nearly all of the well documented pigmentation genes were replicated, including <em>MC1R, SLC45A2, TYR, IRF4, HERC2, KITLG</em> and <em>SLC24A4</em> and results generally agreed with studies performed in the past. …”

Establishment of optimise strategies in production of recombinant Hepatitis B surface antigen for chip-based antibody detection approach by Tam, Yew Joon

“…The use of the pPIC3.5K-HBsAg plasmid in the Mut+ phenotype enhanced the expression of HBsAg by a nearly 13 times higher volumetric productivity in the first 24 h and 35 times higher at peak production concentration. …”
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Compositionally graded alloys fabricated using the laser powder bed fusion technique by Wei, Siyuan

“….% Ni was proved to be the lower threshold for fabricating nearly full-density Cu-Ni binary alloy. Cu-7.6Ni-3Al (wt.%) was further designed and fabricated. …”
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Fabrication and characterization of graphene and carbon nanotube reinforced bioceramic nanocomposites by Hu, Huanlong

“…The maximum wear track deformation and wear volume loss demonstrated nearly perfect quadratic and linear relations, respectively. …”
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