Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I by Liu, X, Zhang, Z, Aguirre, T, Shipton, ML, Fu, L, Du, J, Furkert, D, Qi, J, Chin, AC, Riley, AM, Liu, T, Zhang, X, Potter, BVL, Fiedler, D, Zhu, Y, Fu, C

“…Depleting 5PP-InsP₅ by deleting IP6K1 or blocking IP6K1 activity disrupts the interaction between UBE4A and apoA-I, preventing apoA-I degradation, leading to increased production of apoA-I. …”

Potent antimyeloma activity of the novel bromodomain inhibitors I-BET151 and I-BET762 by Chaidos, A, Caputo, V, Gouvedenou, K, Liu, B, Marigo, I, Chaudhry, M, Rotolo, A, Tough, DF, Smithers, NN, Bassil, AK, Chapman, TD, Harker, NR, Barbash, O, Tummino, P, Al-Mahdi, N, Haynes, AC, Cutler, L, Le, B, Rahemtulla, A, Roberts, I, Kleijnen, M, Witherington, J, Parr, NJ, Prinjha, RK, Karadimitris, A

“…In contrast, transcriptional upregulation of HEXIM1 is BRD2-4 independent. Finally, preclinical studies show that I-BET762 has a favorable pharmacologic profile as an oral agent and that it inhibits myeloma cell proliferation, resulting in survival advantage in a systemic myeloma xenograft model. …”

China : one year after September 11 by Tang, Shiping

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One-step disposable optical waveguide immunosensors by Zhou, Yan, Lam, Yee Loy

“…To develop one-step disposable optical waveguide immunosensors.…”
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Singapore One : multimedia broadband infrastructure for everyone by Tan, Chin Tuan.

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Free-standing one-dimensional plasmonic nanostructures by Jiang, Lin, Sun, Yinghui, Huo, Fengwei, Zhang, Hua, Qin, Lidong, Li, Shuzhou, Chen, Xiaodong

“…In this feature article, a category of chemically nanofabricated, unique free-standing one-dimensional (1D) plasmonic nanostructures has been summarized. …”
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Evaluation of population immunity against SARS-CoV-2 variants, EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1 using samples from two health demographic surveillance systems in Kenya by Lugano, D, Kutima, B, Kimani, M, Sigilai, A, Gitonga, J, Karani, A, Akech, D, Karia, B, Ziraba, AK, Maina, A, Lambisia, A, Omuoyo, D, Mugo, D, Lucinde, R, Owuor, S, Konyino, G, Newman, J, Bailey, D, Nduati, E, Githinji, G, Agoti, CN, Bejon, P, Scott, JAG, Agweyu, A, Warimwe, GM

“…Our data show that antibodies from individuals in the general population in Kenya were less effective against the recent prevalent SARS-CoV-2 omicron variants (i.e. EG.5.1, FY.4, BA.2.86, JN.1, JN.1.4, and KP.3.1.1) compared to the ancestral wildtype strain. …”

Temperature-dependent ultrafast carrier and phonon dynamics of topological insulator Bi1.5Sb0.5Te1.8Se1.2 by Cheng, Liang, La-o-vorakiat, Chan, Tang, Chi Sin, Nair, Saritha K., Xia, Bin, Wang, Lan, Zhu, Jian-Xin, Chia, Elbert E. M.

“…Using ultrafast optical pump-probe technique, we studied the temperature-dependent carrier and phonon dynamics of the topological insulator Bi1.5Sb0.5Te1.8Se1.2 single-crystal from 10 K to 300 K. …”
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Preparation of 1T′-phase ReS2xSe2(1‑x) (x = 0−1) nanodots for highly efficient electrocatalytic hydrogen evolution reaction by Lai, Zhuangchai, Chaturvedi, Apoorva, Wang, Yun, Tran, Thu Ha, Liu, Xiaozhi, Tan, Chaoliang, Luo, Zhimin, Chen, Bo, Huang, Ying, Nam, Gwang-Hyeon, Zhang, Zhicheng, Chen, Ye, Hu, Zhaoning, Li, Bing, Xi, Shibo, Zhang, Qinghua, Zong, Yun, Gu, Lin, Kloc, Christian, Du, Yonghua, Zhang, Hua

“…Here, by combining chemical vapor transport and Li-intercalation, we have prepared a series of 1T′-phase ReS2xSe2(1-x) (x = 0–1) nanodots to achieve high-performance HER in acid medium. …”
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…The effect was maximal when KCa3.1 activation and Kv11.1 inhibition were combined. …”
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Development of applications for mobile devices I by Panganiban, Nicole Dale

“…Although such service was already available online, as the technology continues to progress developers looked into the ease of use of portable digital devices such as mobile phones. Smart phones became a necessity to most people. …”
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Fatigue behaviors of square-to-square hollow section T-joint with corner crack I : experimental studies by Chiew, Sing Ping, Ji, Hong Li, Lee, Chi King, Lie, Seng Tjhen

“…Fatigue test results and crack geometry measurements showed that under cyclic loading, cracks will be initiated at one of the four corners of the brace-chord intersection and propagate mainly in the direction parallel to the chord wall. …”
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Functional roles of transforming growth factor activated Kinase-1 (TAK1) in skin wound healing by Tan, Siew Hwey

“…We show here that during wound healing, TAK1 activates von Hippel-Lindau tumor suppressor (pVHL) expression in keratinocytes which, in turn, represses the expression of PDGF-B and, integrins beta1 and beta5 via inhibition of the Sp1-mediated transcription. …”
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Development of iBeacon application 3 by Choar, Choong Leong

“…This project mainly focuses on the development of the iBeacon, which is one of the components in IoT to create a more comprehensive automation system. …”
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Preparation of Single-Layer MoS2xSe2(1-x) and MoxW1-xS2 Nanosheets with High-Concentration Metallic 1T Phase by Tan, Chaoliang, Zhao, Wei, Chaturvedi, Apoorva, Fei, Zhen, Zeng, Zhiyuan, Chen, Junze, Huang, Ying, Ercius, Peter, Luo, Zhimin, Qi, Xiaoying, Chen, Bo, Lai, Zhuangchai, Li, Bing, Zhang, Xiao, Yang, Jian, Zong, Yun, Jin, Chuanhong, Zheng, Haimei, Kloc, Christian, Zhang, Hua

Subjects: “…MoS2xSe2(1−x)…”
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A standardised fraction 1 (SF1) from clinacanthus nutans attenuates the stemness of cervical cancer stem-like cells via inhibition of notch1 signalling by Ismail, Faridah

“…This implies that SF1 may act by promoting proteasomal degradation of Notch1 protein or disrupting its translation process. …”
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Arthroscopic Bone Block and Arthroscopic Latarjet for Anterior Shoulder Dislocation—Technical Note with Tricks and Tips for Conversion and Successful Surgery by Longo, Umile Giuseppe, Marcello, Gianmarco, Nazarian, Ara, DeAngelis, Joseph, D’Hooghe, Margaux, D’Hooghe, Pieter

“…Even though the indication to perform a free bone block or a Latarjet procedure may be given preoperatively, in cases where the choice between the two procedures is unclear, the decision can be made intraoperatively, given the possibility to switch from one to another. …”
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“I’m cantonese but I speak hokkien” : a case study of a Chinese Singaporean family. by Ng, Li Yan.

“…A case study was carried out by conducting semi-structured interviews with members of one particular family in which both children are proficient in only one of their inherited dialects – Hokkien. …”
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Functional characterization of plasmodium falciparum reticulocyte binding like protein homologue 1 (PfRH1) by Yap, Sally Shu Lin

“…Human malaria parasites, Plasmodium falciparum, invade human erythrocytes through multiple ligand-receptor interactions. One of the protein families involved in invasion, reticulocyte binding like protein homologues (PfRHs) has been suggested to be involved in host cell selection. …”
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Thank God, I've finally found the one : dating culture of Christian young adults in Singapore by Ho, Gabriel Chee Chuan, Ho, Shu Hui, Khong, Zoey

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