Structural and functional characterisation of chikungunya virus replication complex dynamics by Tan, Yaw Bia

“…Through mosquito bites, the infected victims develop Chikungunya Fever (CHIKF) associated with symptoms like acute fever and painful polyarthritis. Unfortunately, there are no current effective antiviral drugs and vaccine treatments against CHIKV and many other +ssRNA viruses due to the inadequacy of biological information of its replication complex (RC) formations and the process of viral replications. …”
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A population-based cohort study examining the incidence and impact of psychotic experiences from childhood to adulthood, and prediction of psychotic disorder by Sullivan, SA, Kounali, D, Cannon, M, David, AS, Fletcher, PC, Holmans, P, Jones, H, Jones, PB, Linden, DEJ, Lewis, G, Owen, MJ, O'Donovan, M, Rammos, A, Thompson, A, Wolke, D, Heron, J, Zammit, S

“…<p><strong>Methods:</strong></p> This was a population-based cohort study using the semistructured Psychosis-Like Symptoms Interview at ages 12, 18, and 24 (N=7,900 with any data). …”

Addressing inequities in research for early to mid-career women scientists in low- and middle-income countries: “Supporting Women in Science” programme by Das, JK, Raza, M, Padhani, ZA, Hussain, NF, Villar, J, Kennedy, S, Bhutta, ZA

“…Capacity-building initiatives like SWIS are crucial interventions to empower women scientists, foster equitable representation in academia, and create inclusive research environments and the programme acts as a steppingstone for future global leaders.…”

The critical role of IL-23 receptor positive T cells in the pathogenesis of anterior uveitis associated with spondyloarthropathy by Hedley, R

“…Consistent with the concept of IL-23 being a unifying factor in SpA, I show that like the gut, skin, and joints - IL-23 can also act locally on a resident IL-23 responsive cells to drive pathology within the eye.…”

Exploring the composition of placental microbiome and its potential origin in preterm birth by Saadaoui, M, Djekidel, MN, Murugesan, S, Kumar, M, Elhag, D, Singh, P, Kabeer, BSA, Marr, AK, Kino, T, Brummaier, T, McGready, R, Nosten, F, Chaussabel, D, Terranegra, A, Al Khodor, S

“…Additionally, it’s unclear whether the placental microbiome differs between healthy pregnancies and those with complications like preterm birth (PTB), which remains a leading cause of neonatal morbidity and mortality worldwide. …”

Paradoxical choice and the value of information in animals by Ajuwon, V

“…</p> <br> <p>In Chapter 4, I use <em>GoFish</em> and the paradoxical choice protocol to explore non-instrumental information-seeking in fish (goldfish) for the first time. Like in birds and mammals, fish learned the programmed contingencies and showed rational preferences between stimuli predicting differing reward probabilities, but, unlike the other vertebrates studied so far, this did not translate into a preference for signalled outcomes.…”

Profiling the growth conditions and persistent organic pollutants (POPS) tolerance of Phenoliferia glacialis USM-PSY62 by Ain Nur Afifah Azman, Shazilah Kamaruddin, Quay, Doris Huai Xia, Farah Diba Abu Bakar, Noor Haza Fazlin Hashim, Abdul Munir Abdul Murad, Izwan Bharudin

“…These microorganisms have special adaptations to extreme cold and low-nutrient conditions. Some extremophiles, like psychrophiles can thrive in these harsh environments. …”
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Multi-Objective Multi-Exemplar Particle Swarm Optimization Algorithm with Local Awareness by Noori, Mustafa Sabah, Sahbudin, Ratna K.Z., Sali, Aduwati, Hashim, Fazirulhisyam

“…One of these MOO algorithms Multi-Objective Particle Swarm Optimization (MOPSO) extends it to handle problems with multiple objectives simultaneously, but like many swarm-based algorithms, MOPSO can suffer from premature convergence or local optima solutions. …”
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Maximizing the performance of badminton athletes through core strength training: Unlocking their full potential using machine learning (ML) modeling by Ma, Shuzhen, Geok Soh, Kim, Japar, Salimah, Xu, Simao, Zhicheng, Guo

“…A comprehensive literature review was conducted to explore the biomechanical demands of badminton and how core musculature contributes to movements like serving, smashing, and lunging. Studies assessing the effects of core training programs in related racquet sports were also examined. …”
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Fluorescent imaging and bio-cellular uptake assessment of gold-near infrared dye conjugated cockle shell calcium carbonate nanoparticles by Kiranda, H.K., Mahmud, R.B., Mahmood, S.K., Zakaria, Z.A.

“…Biocompatibility of Au-CsCaCO3NPs in cultured human breast carcinoma cells MCF-7 and mouse embryonic fibroblast cells NIH3T3 was evaluated using bioassays like Lactate Dehydrogenase LDH and Reactive Oxygen Species ROS for toxic examination. …”
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Enhancing indoor positioning accuracy with WLAN and WSN: a QPSO hybrid algorithm with Surface tessellation by Scavino, Edgar, Abd Rahman, Mohd Amiruddin, Farid, Zahid, Ahmad, Sadique, Asim, Muhammad

“…Moreover, satellite-based Global Positioning System (GPS) signals are likely to be unusable in deep indoor spaces, and technologies like WiFi and Bluetooth are susceptible to signal noise and fading effects. …”
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Aerodynamic Effects of High-Speed Train Positions During Tunnel Exit Under Crosswind Conditions Using Computational Fluid Dynamics by Rajendran, S, Ishak, I. A, Arafat, M, Mohammad, A. F, Salleh, Z. M, Samiran, N. A, Ja’a, M. N. M, Sulaiman, S

“…Strong crosswinds can cause catastrophic accidents like overturning and derailment in extreme circumstances, therefore the train's capacity to tolerate their impacts is crucial. …”
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A feedforward neural network based indoor-climate control framework for thermal comfort and energy saving in buildings by Chaudhuri, Tanaya, Soh, Yeng Chai, Li, Hua, Xie, Lihua

“…Proposed framework exhibits an energy saving potential of 36.5%. It is found that 25 °C is the ideal air temperature for desired comfort with minimum energy expense in the tropical buildings. …”
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Sequence- and structure-specific probing of RNAs by short nucleobase-modified dsRNA-binding PNAs incorporating a fluorescent light-up uracil analog by Krishna, Manchugondanahalli Shivakumar, Toh, Desiree-Faye Kaixin, Meng, Zhenyu, Ong, Alan Ann Lerk, Wang, Zhenzhang, Lu, Yunpeng, Xia, Kelin, Prabakaran, Mookkan, Chen, Gang

“…Compared to DNA and RNA, peptide nucleic acids (PNAs) are chemically stable and have a neutral peptide-like backbone, and thus, they show significantly enhanced binding to natural nucleic acids. …”
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A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system by Shen, Yunbing, Jiang, Long, Iyer, Vaishnavi Srinivasan, Raposo, Bruno, Dubnovitsky, Anatoly, Boddul, Sanjaykumar V., Kasza, Zsolt, Wermeling, Fredrik

“…As proof of principle, we present examples studying various aspects related to hematopoietic cells (T cell development in vivo and activation in vitro, differentiation of macrophages and dendritic cells, as well as a leukemia-like phenotype induced by overexpressing a proto-oncogene). …”
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Investigating the role of self-sacrificing prosociality in intragroup and intergroup contexts by Katna, Dashalini P.

“…Studies 4 (N = 299) and 5 (N = 376) revealed indirect effects of U.S. identity salience on restrictive policies toward outgroups like radical Islamic groups and malicious foreign organisations, that emerged through increased self-sacrificial readiness and anticipated outgroup hostility. …”
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A machine-learned approach for reducing airborne delays and environmental impact in terminal manoeuvring area using extended arrival management by Lim, Zhi Jun

“…Results show that $65\%$ of TMA delays can be shifted to the cruise phase, saving 1.5 tonnes of fuel and reducing carbon dioxide emissions by 4.8 tonnes for one day’s arrivals. …”
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Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum by Song, Yutong, Zhao, Zhihao, Xu, Linyu, Huang, Peiyuan, Gao, Jiayang, Li, Jingxuan, Wang, Xuejie, Zhou, Yiren, Wang, Jinhui, Zhao, Wenting, Wang, Likun, Zheng, Chaogu, Gao, Bo, Jiang, Liwen, Liu, Kai, Guo, Yusong, Yao, Xiaoqiang, Duan, Liting

“…To fill the knowledge gap, after developing a light-inducible ER-specific mechanostimulator (LIMER), we identify that mechanostimulation of ER elicits a transient, rapid efflux of Ca2+ from ER in monkey kidney COS-7 cells, which is dependent on the cation channels transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and polycystin-2 (PKD2) in an additive manner. …”
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Induction of z-conformation in ribosomal RNA by Z-DNA binding domain Zα of the human double-stranded RNA deaminase I (ADAR1) by Zhao, Jing

“…We determined 3D solution structures of ZαADAR1 and ZαADAR1 mutant (N43A, Y47A) and compared binding modes of these two proteins to Z-DNA, short (5-32 residues) dsRNA oligonucleotides derived from rRNA and E.coli ribosomes. …”
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Identification and characterisation of novel human dendritic cell progenitors by See, Peter Chi Ee

“…Hence, this might explain why pDC when stimulated with IL-3 and CD40 ligand, were found to differentiate into cells with cDC-like morphology. We also demonstrated that pre-cDC but not pDC were able to differentiate into cDC subsets in MS5 stromal culture supplemented with the cytokines Flt3L, SCF and GM-CSF. …”
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