Transcriptomic changes in oligodendrocytes and precursor cells associate with clinical outcomes of Parkinson’s disease by Dehestani, Mohammad, Kozareva, Velina, Blauwendraat, Cornelis, Fraenkel, Ernest, Gasser, Thomas, Bansal, Vikas

“…We found a significant association of oligodendrocytes (ODCs) and oligodendrocyte precursor cells (OPCs) with PD-linked risk loci and report several dysregulated genes and pathways, including regulation of tau-protein kinase activity, regulation of inclusion body assembly and protein processing involved in protein targeting to mitochondria. …”
Get full text

Inter-laboratory comparison of eleven quantitative or digital PCR assays for detection of proviral bovine leukemia virus in blood samples by Pluta, Aneta, Jaworski, Juan P., Droscha, Casey, VanderWeele, Sophie, Taxis, Tasia M., Valas, Stephen, Brnić, Dragan, Jungić, Andreja, Ruano, María J., Sánchez, Azucena, Murakami, Kenji, Nakamura, Kurumi, Puentes, Rodrigo, De Brun, MLaureana

“…Agreement amongst different assays was linked to BLV copy numbers present in samples and the characteristics of each assay (i.e., BLV target sequence). …”
Get full text

ProtAgents: Protein discovery via large language model multi-agent collaborations combining physics and machine learning by Ghafarollahi, Alireza, Buehler, Markus J.

“…Current methodologies for protein design often rely on AI-based models, such as surrogate models that address end-to-end problems by linking protein structure to material properties or vice versa. …”
Get full text

Hidden Influence in Dynamic Networks by Erhardt, Keeley Donovan

“…These networks consist of nodes (entities) and edges (connections) that dynamically evolve, reflecting changes in relationships, the emergence of new entities, and the dissolution of old links. Unlike static networks, which offer a snapshot of connections at a specific time, dynamic networks allow for modeling processes and system-level changes over time. …”
Get full text
Get full text

Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death by Martínez, Pablo, Silva, Mónica, Abarzúa, Sebastián, Tevy, María F., Jaimovich, Enrique, Constantine-Paton, Martha, Bustos, Fernando J., van Zundert, Brigitte

“…A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxicity of MNs. …”
Get full text

Effect of a high strength chemical industry wastewater on microbial community dynamics and mesophilic methane generation by Venkatakrishnan, Harish, Tan, Youming, Majid, Maszenan bin Abdul, Pathak, Santosh, Sendjaja, Antonius Yudi, Li, Dongzhe, Liu, Jerry Jian Lin, Zhou, Yan, Ng, Wun Jern

“…This study suggested that the degradation of organic components within the high strength industrial wastewater is closely linked with the activity of certain niche microbial communities within eubacteria and methanogens.…”
Get full text
Get full text

3D carbon/cobalt-nickel mixed-oxide hybrid nanostructured arrays for asymmetric supercapacitors by Zhu, Jianhui, Jiang, Jian, Sun, Zhipeng, Luo, Jingshan, Fan, Zhanxi, Huang, Xintang, Zhang, Hua, Yu, Ting

“…Two such supercapacitors linked in series can simultaneously power four distinct light-emitting diode indicators; they can also drive the motor of remote-controlled model planes. …”
Get full text
Get full text

Ultracompact high-sensitivity biosensing based on regenerable laminated bio-conjugation in integrated photonic circuits by Li, Z. Y., Chen, Y. Y., Xiong, S., Truc, N. K., Xiong, Q. H., Liu, Ai Qun

“…LOD can be improved to 30 ng/mL after linking the detection antibody. After associating with the layer-by-layer structure composed by HRP and anti-HRP antibody on the sandwich assay, LOD can be improved to several pg/mL. …”
Get full text

Identification of RNA-Tis11b complexes in activated B cells. by Tang, Ngang Heok.

“…Our data suggest that Tis11b may play a role during B cell activation processes and SB1/56.6 antibody could be used in cross-linking immunoprecipitation (CLIP) experiment to identify full spectrum of RNA targets of Tis11b. …”
Get full text

The relationship between self-perceived burden, depression, medication adherence, and health-related quality of life in coronary heart disease patients by Lim, Benjamin Chee Chong

“…Although self-perceived burden has been consistently linked to health-related quality of life (HRQOL), its underlying mechanisms remain unexplored, particularly in coronary heart disease (CHD) patients. …”
Get full text

Continuous treatment of the organic fraction of municipal solid waste in an anaerobic two-stage membrane process with liquid recycle by Trzcinski, A.P., Stuckey, David Campbell

“…The operation was not sustainable below this HRT due to a membrane flux limitation at 0.5–0.8 L/m2 h (LMH), which was linked to the increasing MLTSS. SCOD in the recycled permeate did not build up indicating a slow degradation of recalcitrants over time. …”
Get full text
Get full text

MEG Insight into the Spectral Dynamics Underlying Steady Isometric Muscle Contraction by Bourguignon, Mathieu, Piitulainen, Harri, Smeds, Eero, Zhou, Guangyu, Jousmäki, Veikko, Hari, Riitta

“…Thus, ∼20 Hz coherence between cortex and periphery is tightly linked to the presence of ∼20 Hz bursts in SM1 and peripheral activity. …”
Get full text
Get full text

Cross-reactive dengue human monoclonal antibody prevents severe pathologies and death from Zika virus infections by Kam, Yiu-Wing, Lee, Cheryl Yi-Pin, Teo, Teck-Hui, Howland, Shanshan W., Siti Naqiah Amrun, Lum, Fok-Moon, See, Peter, Kng, Nicholas Qing-Rong, Huber, Roland G., Xu, Mei-Hui, Tan, Heng-Liang, Choo, Andre, Maurer-Stroh, Sebastian, Ginhoux, Florent, Fink, Katja, Wang, Cheng-I, Ng, Lisa F.P., Rénia, Laurent

“…Zika virus (ZIKV) infections have been linked with neurological complications and congenital Zika syndrome. …”
Get full text
Get full text

Taste and see: real presence as revelation in Heideggerian perspective by Olson, JW

“…Heidegger’s notion of Being-in-the-world opens up a new definition of understanding, where what is primary is praxis in the form of worldly involvement, so that understanding in the form of habits, mood, and know-how becomes foundational for any knowledge of the beings with which we interact. Language is then linked up with this pre-reflective understanding, first as discourse and then later as poetry, both of which disclose a fundamental world-orientation to language.…”

Mapping the extent and exploring the drivers of cocoa agroforestry in Nigeria, insights into trends for climate change adaptation by Koralewicz, A, Vlcek, J, Oliveras-Menor, I, Hirons, M, Akinyugha, A, Sikiru Olowoyo, O, Oluyemi, M, Owen, O

“…In Nigeria, modernization efforts promoting full-sun cocoa have been linked to deforestation and biodiversity loss. The promotion of traditional cocoa agroforestry methods are regaining interest as an approach to climate adaptation and forest restoration. …”

An exploratory study on the development of a sensory wheel affiliated with the emotional lexicon for chrysanthemum infusion by Xia, Y, Hou, J, Chen, J, Spence, C, Qian, J, Zhao, F, Dong, G, Zhong, F

“…However, sensory attributes such as bitterness, astringency, and vegetal aroma were linked to negative emotions and were sometimes associated with feelings of activity. …”

The influence of tropical cyclones on mixed-population flood frequency analysis by Wang, L, Gu, X, Slater, LJ, Li, J, Lai, Y, Zhang, X, Dai, J, Chen, Y

“…Our results show that TC-induced floods in inland areas are not always found along the TC path but can be located about 1000 km ahead, which is linked to TC-induced predecessor rain events. Extreme floods associated with TCs are generally larger in coastal areas compared to those in inland areas, whereas TC-induced floods in some inland areas tend to be more extreme relative to their local flood magnitude. …”

External validation of the QCovid 2 and 3 risk prediction algorithms for risk of COVID-19 hospitalisation and mortality in adults: a national cohort study in Scotland by Kerr, S, Millington, T, Rudan, I, McCowan, C, Tibble, H, Jeffrey, K, Fagbamigbe, AF, Simpson, CR, Robertson, C, Hippisley-Cox, J, Sheikh, A

“…Primary care data were linked to reverse-transcription PCR virology testing, hospitalisation and mortality data. …”

Mapping the extent and exploring the drivers of cocoa agroforestry in Nigeria, insights into trends for climate change adaptation by Koralewicz, A, Vlcek, J, Menor, IO, Hirons, M, Akinyugha, A, Olowoyo, OS, Ajayi-Ebenezer, M, Owen, O

“…In Nigeria, modernization efforts promoting full-sun cocoa have been linked to deforestation and biodiversity loss. The promotion of traditional cocoa agroforestry methods are regaining interest as an approach to climate adaptation and forest restoration. …”

Oxazolidinone antibiotics impair ex vivo megakaryocyte differentiation from hematopoietic progenitor cells and their maturation into platelets by Milosevic, TV, Vertenoeil, G, Vainchenker, W, Tulkens, PM, Constantinescu, SN, Van Bambeke, F

“…Pharmacological interventions to prevent this toxicity might therefore be difficult as mitochondrial toxicity is most probably inherently linked to their antibacterial activity.…”