Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1 by Stubna, Michael William

“…TDMD underlies the instability of many miRNAs in diverse cell lines and animals. In this work, I probe the biological scope of TDMD as a regulatory mechanism in the nematode Caenorhabiditis elegans, which tolerates homozygous loss of the ZSWIM8 ortholog, EBAX-1, and expresses some miRNAs that are subject to rapid, developmentally regulated decay. …”
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Development of immunomodulatory RNA therapeutics for immune disorders by Iyer, Vaishnavi Srinivasan

“…We show that these ASOs can modulate T cell behavior in human cell lines and human primary cells, validating the potential of ASOs as a therapeutic approach for immune diseases. …”
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Data-driven distributionally robust CVaR portfolio optimization under a regime-switching ambiguity set by Pun, Chi Seng, Wang, Tianyu, Yan, Zhenzhen

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Financial forecasting using meta-cognitive fuzzy neural networks by Singh Akhand Pratap

“…The primary meta-cognitive strategies are Sample deletion, Sample Learning and Sample Reserve. Following on the lines of Technical Analysis carried out by traders and investors on the historical prices of a company’s stock, the project makes use of various Financial Indicators to decide whether a particular instance of time is good for investment, disinvestment or to remain idle. …”
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Taliban resurgence in Afghanistan : the role of post-conflict reconstruction by Sadia Sulaiman

“…Under the auspices of Bonn-I, the international community initiated a process of post-conflict reconstruction on both security and non-security lines. Bonn-I provided a framework for setting up an interim government tasked with drafting a constitution, convening a Loya Jirga (grand assembly), holding presidential and parliamentary elections by 2005, strengthening the Afghan police and military forces, and establishing a judicial system. …”
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Multi-spectral polarimetry imaging for early gastric cancer diagnosis by Wang, Wenfeng

“…Gastric cancer, which develops from the lining of stomach, is the fifth most severe disease worldwide. …”
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The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells by Pillozzi, Serena, D'Amico, Massimo, Bartoli, Gianluca, Gasparoli, Luca, Petroni, Giulia, Crociani, Olivia, Marzo, Tiziano, Guerriero, Angela, Messori, Luigi, Severi, Mirko, Udisti, Roberto, Wulff, Heike, Chandy, Kanianthara George, Becchetti, Andrea, Arcangeli, Annarosa

“…Methods: The functional expression of Ca2+-activated (KCa3.1, also known as KCNN4) and voltage-dependent (Kv11.1, also known as KCNH2 or hERG1) K+ channels was determined in two CRC cell lines (HCT-116 and HCT-8) by molecular and electrophysiological techniques. …”
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Design and Synthesis of Stimuli-Responsive Polymers with Programmable Cleavability by Zafar, Hadiqa

“…The second chapter reports the first synthesis of peptide-containing bivalent bottlebrush (co)polymers (BBPs), featuring caspase-3-cleavable peptides linked to fluorogenic probes that provide a “turnon” signal upon enzymatic cleavage. …”
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Mapping the Cellular Landscape of the Brain: A Scalable Approach to Comprehensive Microscopy Data Analysis by Kim, Minyoung E.

“…Given that cellular morphology is strongly linked to distinct functional states of cells, in-depth morphological analysis of such data offers immense potential for understanding their roles in brain development and disease. …”
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Design of Cleavable Monomers and Cross-Linkers for the Synthesis of Degradable Polymer Architectures by Cardoso da Costa, Leticia

“…A brief introduction to the current strategies utilized to impart chemical deconstruction to cross-linked polymer networks prepared by radical polymerization is presented (Chapter 4). …”
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Phonological and semantic influences on auditory word perception in children with and without reading impairments using magnetoencephalography (MEG) and electroencephalography (EEG... by Wehner, Daniel T

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新加坡和 “一带一路” ：国家与社会的视角和策略 = Singapore and the belt and road initiative : perspectives and strategies from the state and society by 范昕 Fan, Xin

“…It argues that the two key factors for Singapore’s fruitful participation in the BRI are the state’s leadership and the transnational network’s coordination. These are in turn linked with effective institutional mechanisms and smooth implementation of transnational networks. …”
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Organic solvent-assisted control of hydrogel structures and properties by Zhou, Quan

“…Hydrogels are three-dimensional (3D) cross-linked polymeric networks containing a significant amount of water and have found their applications in various fields, including tissue engineering, drug delivery, etc. …”
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Distributed droop schemes for standalone and interlinked AC microgrids by Inam Ullah

“…The formed microgrids can certainly be controlled by centralized management systems, but for widely dispersed DGs where communication links are not viable, autonomous droop schemes might be more appropriate. …”
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Gene expression regulation by well-known non-coding RNAs by Tan, Jiazi

“…In one project, we attempted to insert a second Xist gene into the single X chromosome of male murine embryonic stem (ES) cells to cause ectopic XCI upon differentiation, leading to cell lethality as important X-linked genes were inactivated. From there, we could screen for genes important for XCI by rescuing the differentiated transgenic ES cells by gene silencing. …”
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Robust cooperative control and optimization of multi-agent systems by Sun, Chao

“…Nodes connected with a positive edge can be viewed as “friends” and linked with a negative edge can be viewed as “enemies”. …”
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An epigenetic locus associated with loss of smell in COVID-19 by Aslan, Elif Sibel, White, Kenneth, Meral, Gulsen, Akcay, Zeyneb Nur, Altundag, Aytug, Gur, Savas, Dokur, Mehmet, Baktir, Mehmet Akif, Batur, Lutfiye Karcioglu

“…Previous studies, including genome-wide association studies (GWAS), have identified genetic variants near the UGT2A1 and UGT2A2 genes that are linked to anosmia in COVID-19 patients. However, the role of epigenetic changes in the development and persistence of smell loss has not been well explored. …”
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Impact of co-morbid common mental disorder symptoms in people with epilepsy in Ethiopia on quality of life and functional disability: cohort study by Tsigebrhan, R, Medhin, G, Belina, M, Newton, C, Hanlon, C

“…Structural equation modelling (SEM) was employed to examine direct and indirect pathways linking co-morbid CMD symptoms with QoL or functional disability.…”

Joint modelling of longitudinal data: a scoping review of methodology and applications for non-time to event data by Ouko, RK, Mukaka, M, Ohuma, EO

“…The random effect was the most commonly applied association structure for linking two sub-models (63 studies; 85%). Estimation of model parameters was commonly done using Markov Chain Monte Carlo with Gibbs sampler algorithm (10 studies; 38%) for the Bayesian approach, whereas maximum likelihood was the most common (33 studies; 68.75%) for the frequentist approach. …”

Health economic aspects of childhood excess weight by Onyimadu, O

“…Additionally, electronic health records extracted from the Clinical Practice Research Datalink (CPRD), linked with Hospital Episode Statistics (HES), were analysed to estimate direct healthcare costs attributable to childhood excess weight.…”