Reverse translational approaches to population neuroimaging: using rodent models to interpret genetic associations with MRI by Tisca, C

“…The genetic similarity between humans and mice means we can measure and compare equivalent phenotypes across species. …”

Dysfunctional cardiac energy transduction, mitochondrial oxidative stress, oncogenic and apoptotic signaling in DiNP-induced asthma in murine model by Kehinde, Samuel Abiodun, Olajide, Abosede Temitope, Fatokun, Tolulope Peter, Faroud, Dalia, Hadi, Najah R., Elgazzar, Ahmed M., James, Adewale Segun, Ashour, Mohamed H. Mazhar

“…In the current study, we assessed the crosstalk between DiNP-induced asthma and cardiac cellular respiration, oxidative stress, apoptotic potential, and induction of oncogenic factors. Ten male BALB/c mice with a weight range of 20–30 g were divided into two groups, each comprising five mice. …”
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Determination of the life span of inflammatory dendritic cells by Tay, Yong Long

“…Due to the lack of a proper Plet-1 knockout mice model previously, cell ablation study of Plet-1+ DCs was not possible. …”
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Experimental studies of melting PCM in a heat sink by Muhammad Azrin Sa'ad.

“…The heat sink design that was the focus of this study is based on the pin finned heat sink design. Experiments mainly pertaining to the characteristics of the melting PCM in the heat sinks were observed and recorded to further understand the behaviours and characteristics of the melting PCM. …”
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Pharmacological PPARβ/δ activation upregulates VLDLR in hepatocytes by Zarei, Mohammad, Barroso, Emma, Palomer, Xavier, Escolà-Gil, Joan Carles, Cedó, Lidia, Wahli, Walter, Vázquez-Carrera, Manuel

“…Finally, treatment with another PPARβ/δ agonist increased VLDLR levels in the liver of wild-type mice, but not PPARβ/δ-deficient mice, confirming the regulation of hepatic VLDLR by this nuclear receptor. …”
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Lasting dynamic effects of the psychedelic 2,5-dimethoxy-4- iodoamphetamine ((±)-DOI) on cognitive flexibility by Sabanovic, M, Lazari, A, Blanco Pozo, M, Tisca, C, Tachrount, M, Martins Bach, A, Lerch, J, Walton, M, Bannerman, D

“…Strikingly, (±)-DOI-treated mice started learning from reward omissions, a unique strategy not typically seen in mice in this task, suggesting heightened sensitivity to previously overlooked cues. …”

Investigation of the effects of Anti-Müllerian Hormone on preventing Doxorubicin-induced primordial follicle loss by Wei, X

“…Follicular damage caused by DXR was also demonstrated in adult mouse ovaries in vivo but not in human pre-pubertal ovarian tissue xenotransplanted into mice. Although there were trends, there was no significant effect of AMH treatment alone on inhibiting primordial follicle activation in mouse ovarian tissue (in vitro and in vivo) or human ovarian tissue (xenotransplanted into mice). …”

PPARβ/δ prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism by Salvadó, Laia, Barroso, Emma, Gómez-Foix, Anna Maria, Palomer, Xavier, Michalik, Liliane, Wahli, Walter, Vázquez-Carrera, Manuel

“…Methods Studies were conducted in mouse C2C12 myotubes, in the human myogenic cell line LHCN-M2 and in skeletal muscle from wild-type and PPARβ/δ-deficient mice and mice exposed to a high-fat diet. Results The PPARβ/δ agonist GW501516 prevented lipid-induced ER stress in mouse and human myotubes and in skeletal muscle of mice fed a high-fat diet. …”
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Bacteria-mediated anti-cancer therapy by Bhave, Madhura Satish

“…Notably, when the IB-treated mice were subsequently re-challenged with CT26 cells, the immune mediated-response prevented the establishment of a second tumor in the mice. …”
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Enantiomeric glycosylated cationic block co-beta-peptides eradicate Staphylococcus aureus biofilms and antibiotic-tolerant persisters by Zhang, Kaixi, Du, Yu, Si, Zhangyong, Liu, Yang, Turvey, Michelle E., Raju, Cheerlavancha, Keogh, Damien, Ruan, Lin, Jothy, Subramanion Lachumy, Reghu, Sheethal, Marimuthu, Kalisvar, De, Partha Pratim, Ng, Oon Tek, Mediavilla, José R., Kreiswirth, Barry N., Chi, Robin Yonggui, Ren, Jinghua, Tam, Kam C., Liu, Xue-Wei, Duan, Hongwei, Zhu, Yabin, Mu, Yuguang, Hammond, Paula T., Bazan, Guillermo C., Pethe, Kevin, Chan-Park, Mary Bee Eng

“…Its antibacterial activity is superior to that of vancomycin in MRSA mouse and human ex vivo skin infection models, with no acute in vivo toxicity in repeated dosing in mice at above therapeutic levels. The copolymer displays bacteria-activated surfactant-like properties, resulting from contact with the bacterial envelope. …”
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Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging by Xie, Chen, Zhen, Xu, Lei, Qunli, Ni, Ran, Pu, Kanyi

“…The small size and structurally stable nanostructure, in conjunction with a dense PEG shell, allow SPAs to passively target tumors of living mice after systemic administration, permitting both PA and fluorescence imaging of the tumors at signals that are ≈1.5-fold higher than that of liver. …”
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A semiconducting polymer nano-prodrug for hypoxia-activated synergetic photodynamic cancer therapy by Cui, Dong, Huang, Jiaguo, Zhen, Xu, Li, Jingchao, Jiang, Yuyan, Pu, Kanyi

“…The well-defined and compact nanostructure of SPNpd (30 nm) enables accumulation in the tumor of living mice. Owing to these features, SPNpd exerts synergistic photodynamic and chemo-therapy, and effectively inhibits tumor growth in a xenograft tumor mouse model. …”
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High expression of MnSOD promotes survival of circulating breast cancer cells and increases their resistance to doxorubicin by Fu, Afu, Ma, Shijun, Wei, Na, Tan, Blanche Xiao Xuan, Tan, Ern Yu, Luo, Kathy Qian

“…Cancer cells with high levels of manganese superoxide dismutase (MnSOD) exhibited stronger resistance to shear force-induced apoptosis and formed more lung metastases in mice. These metastasized cells further displayed higher resistance to chemotherapeutic agent doxorubicin, which also generates superoxide in mitochondria. …”
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Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics by Li, Jingchao, Zhen, Xu, Lyu, Yan, Jiang, Yuyan, Huang, Jiaguo, Pu, Kanyi

“…The homologous targeting mechanism allows the activated fibroblast cell membrane coated SPN (AF-SPN) to specifically target cancer-associated fibroblasts, leading to enhanced tumor accumulation relative to the uncoated and cancer cell membrane coated counterparts after systemic administration in living mice. As such, AF-SPN not only provides stronger NIR fluorescence and photoacoustic (PA) signals to detect tumors, but also generates enhanced cytotoxic heat and single oxygen to exert combinational photothermal and photodynamic therapy, ultimately leading to an antitumor efficacy higher than the counterparts. …”
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Hybrid biometric authentication for automatic teller machine by Arokiasamy, Steven R., Tomal, Md Raihanul Islam, Moorthy, Kohbalan, Mohd Daud, Kauthar

“…Unlike traditional password or PIN-based methods, biometric authentication uses unique physical characteristics, such as fingerprints, to verify identity. …”
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Investigating viral glycosylation pathways for drug and vaccine development by Brun, J

“…Chapter 4 focuses on the site-specific glycosylation occupancy, and N- and O-glycan structures attached to virion derived SARS-CoV-2 spike glycoproteins. This glycan signature was compared to a stabilised prefusion trimeric spike, to a monomeric subunit of spike (S1) and to an antigen of a non-stabilised vaccine candidate, revealing subunit shedding of the S1 glycoprotein for the vaccine candidate. …”

Comparative effects of domain-specific human monoclonal antibodies against LGI1 on neuronal excitability by Sell, J, Rahmati, V, Kempfer, M, Irani, SR, Ritzau-Jost, A, Hallermann, S, Geis, C

“…However, only the LRR-specific mAbs increased the number of action potential firing together with enhanced initial instantaneous frequency and promoted spike-frequency adaptation, which were less pronounced after the EPTP mAb. …”

Design of a dual band planar inverted-F antenna for GMS/DCS mobile handset by Fang, Jun

“…This project involved the study of size miniaturization of microstrip antenna techniques: shorting pin and shorting wall, loading, shorted spiral printed antenna and stacked shorted patch antenna are fully discussed.…”
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Study on the wear characteristics of aluminium metal matrix composite with 15% Al2O3 and 20% Al2O3 by Chua, Swu Chun.

“…The objective of this dissertation was to study the wear characteristics and behaviour of aluminium metal matrix composite materials (MMCs), namely Duralcan 286 and Duralcan 284 as a pin material when mated against three types of dics materials.…”
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OCT Intensity of the Region between Outer Retina Band 2 and Band 3 as a Biomarker for Retinal Degeneration and Therapy by Zeng, Yong, Gao, Shasha, Li, Yichao, Marangoni, Dario, De Silva, Tharindu, Wong, Wai T., Chew, Emily Y., Sun, Xun, Li, Tiansen, Sieving, Paul A., Qian, Haohua

“…Gene replacement therapy in Rs1KO mice reverted the ORB pattern to one resembling WT and increased the Dip ratio. …”
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