Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms by Sun, Yang, Chung, Hwa Hwa, Woo, Amanda Rui En, Lin, Valerie C.-L.

“…In conclusion, PRMT6 requires its methyltransferase activity to enhance ERα's ligand-induced activity, but its effect on ligand-independent activity is likely mediated through competing with Hsp90 for binding to the C-terminal domain of ERα. …”
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The theoretical direct-band-gap optical gain of Germanium nanowires by Xiong, Wen, Wang, Jian-Wei, Fan, Weijun, Song, Zhigang, Tan, Chuan Seng

“…When taking into account free-carrier absorption loss, the calculated results show that a positive net peak gain is most likely to occur in the heavily doped nanowires with smaller diameters. …”
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Fluid fluxing and accumulation drive decadal and short-lived explosive basaltic andesite eruptions preceded by limited volcanic unrest by Utami, Sri Budhi, Costa, Fidel, Lesage, Ph., Allard, P., Humaida, H.

“…The textures and compositional zoning of orthopyroxene and plagioclase do not support intrusion of more primitive magma as the driver for the eruption, and we instead propose that pre-eruptive fluid accumulation and hightemperature fluid fluxing from depth (likely dominated by CO2) played a major role in priming the eruption to occur. …”
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Insertion of core CpG island element into human CMV promoter for enhancing recombinant protein expression stability in CHO cells by Mariati, Yeo, Jessna H. M., Koh, Esther Y. C., Ho, Steven C. L., Yang, Yuansheng

“…The human cytomegalovirus promoter (hCMV) is susceptible to gene silencing in CHO cells, most likely due to epigenetic events, such as DNA methylation and histone modifications. …”
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Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility by Kurochkin, Igor V., Alkuraya, Fowzan S., Iwasa, Hiroyasu, Akita, Masumi, Tsukui, Tohru, Ito, Chizuru, Shimozawa, Nobuyuki, Iseki, Mioko, Mizuno, Yumi, Ninomiya, Yuichi, Nakachi, Yutaka, Toshimori, Kiyotaka, Nishimukai, Megumi, Hara, Hiroshi, Maeba, Ryouta, Okazaki, Tomoki, Alodaib, Ali Nasser Ali, Amoudi, Mohammed Al, Jacob, Minnie, Horai, Yasushi, Watanabe, Mitsuhiro, Motegi, Hiromi, Wakana, Shigeharu, Noda, Tetsuo, Mizuno, Yosuke, Schönbach, Christian, Okazaki, Yasushi

“…These phenotypic features are most likely the result of changes in the molecular species composition of choline and ethanolamine plasmalogens. …”
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Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics by Wilde, Joshua T., Springs, Stacy, Wolfrum, Jacqueline M., Levi, Retsef

“…Additionally, HMMScan indicates the particular lots most likely to be related to risky states of the manufacturing or supply chain condition. …”
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Insights from an Experiment Crowdsourcing Data from Thousands of US Amazon Users: The importance of transparency, money, and data use by Berke, Alex, Mahari, Robert, Pentland, Sandy, Larson, Kent, Calacci, Dana

“…Age, race, education, and gender also played a role, where female and less-educated participants were more likely to share. Our study design enables a unique empirical evaluation of the “privacy paradox”, where users claim to value their privacy more than they do in practice. …”
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Facilitating gamified lower-extremity rehabilitation through novel VR MI-BCI system by Pramotedham, Chavalit

“…Additionally, while the difference in BCI performance in VR vs. 2D was not deemed to be statistically significant (p = 0.38), this is likely due to the extremely small sample size (n = 12) within this preliminary study. …”
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3D confined jet scour at a wall by Chee, Wei Hong

“…Beyond the jet outlet location, the scoured sediment bed was observed to be uneven likely due to the recirculating flow affected by the ridges formed. …”
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Island area and remoteness shape plant and soil bacterial diversity through land use and biological invasion by Xu, Mingshan, Yang, Anna, Yang, Xiaodong, Cao, Wenting, Zhang, Zengke, Li, Zengyan, Zhang, Yu, Zhang, Huaguo, You, Wenhui, Yan, En-Rong, Wardle, David A.

“…Soil bacterial diversity was directly negatively impacted by island remoteness, and indirectly negatively impacted by island remoteness through increased soil electrical conductivity likely caused by greater salinity from sea spray. …”
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Sustainable structural design optimization - prestressed concrete beams by Ng, Kok Hang

“…The case study revealed that for an 18 m wide bridge, a 3-beam layout generates lesser overall EC than a 4-beam layout and a beam length (thus column spacing) of 20 to 26 m is likely to produce the lowest EC for the bridge system. …”
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Three essays on corporate finance by Sun, Rui

“…Special features of private firms – more concentrated equity ownership, more powerful shareholders with a strong desire for liquidity and diversification, and higher agency costs associated with debt finance are very likely to play a vital role in shaping their cash flow allocation. …”
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Rapid and punctuated Late Holocene recession of Siling Co, central Tibet by Shi, Xuhua, Kirby, Eric, Furlong, Kevin P., Meng, Kai, Robinson, Ruth, Lu, Haijian, Wang, Erchie

“…Mapping and surveying of lacustrine shorelines coupled with optically stimulated luminescence dating of associated deposits indicate protracted occupation of a highstand elevation from >8 ka to 4 ka, followed by rapid recession that was likely punctuated by several stillstands of centennial-scale duration. …”
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Morphology control and thermal stability of binderless-graphene aerogels from graphite for energy storage applications by Nguyen, Son Truong, Nguyen, Hoa Tien, Rinaldi, Ali, Nguyen, Nam P. V., Fan, Zeng, Duong, Hai Minh

“…Of all the challenges facing human beings in the near future, energy related issues are likely to be the grandest. To achieve a more sustainable society with adequate renewable energy and less environmental pollution, more versatile, robust and efficient approaches in electric energy storage and conversion are needed. …”
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Characterising the T cell responses to SARS-CoV-2 including variants of concern induced by natural infection and vaccines by Adele, S

“…Notably, Omicron’s high mutation count challenges antibody responses, yet T cell responses remain comparatively maintained, likely mitigating severe outcomes during Omicron waves.…”

A comparison of sodium-glucose co-transporter 2 inhibitor kidney outcome trial participants with a real-world chronic kidney disease primary care population by Forbes, AK, Hinton, W, Feher, MD, Elson, W, Ordóñez-Mena, JM, Joy, M, Fan, X, Banerjee, D, Cole, NI, Munro, N, Whyte, M, Suckling, RJ, Swift, PA, de Lusignan, S

“…Females were under-represented and less likely to be eligible for the trials.</p> <br> <p><strong>Conclusion:</strong> SGLT2 inhibitor kidney outcome trials represent a subgroup of people with CKD at high risk of adverse kidney events. …”

The influence of nicotinic acid adenine dinucleotide phosphate (NAADP) signalling and the significance of the organization of lysosomes in cardiac myocytes by Aston, D

“…</p> <p>Calcium released from the lysosome in response to NAADP action at TPC2 is thought to modulate calcium release from the SR. This process is likely to require a close spatial relationship between these organelles. …”

HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…<p>Anti-IgLON5 disease is a rare and likely underdiagnosed subtype of autoimmune encephalitis. …”

Environmental risk factors for self-harm during imprisonment: a prospective cohort study by Stephenson, T, Harris, I, Armstrong, C, Fazel, S, Short, R, Blackwood, N

“…Findings regarding staff-prisoner ratio and self-harm most likely reflect a reverse causal relationship. Replication in larger cohort studies is required to address the limitations of this pilot study.…”

The impact of social isolation on delayed hospital discharges of older hip fracture patients and associated costs by Landeiro, F, Leal, J, Gray, A

“…Patients who were admitted from an institution were less likely to have delayed discharges (OR 0.2) with 5.5 fewer days of delay. …”