Assembly of multicyclic isoquinoline scaffolds from pyridines : formal total synthesis of fredericamycin A by Wang, Fang-Xin, Yan, Jia-Lei, Liu, Zhixin, Zhu, Tingshun, Liu, Yingguo, Ren, Shi-Chao, Lv, Wen-Xin, Jin, Zhichao, Chi, Robin Yonggui

“…The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. …”
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Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency by Bao, Caroline

“…This elevated immune response is likely receptor-specific and we have demonstrated that it cannot be attributed to the sensors RIG-I, MDA5, TLR3, or PKR.…”
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Is backsliding possible on Xunzi’s view? by Sung, Winnie

“…Backsliding is possible and likely. I rule out this interpretation because it is inconsistent with other aspects of Xunzi’s thought. …”
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The Origins of the East Greenland Coastal Current on the Northeast Greenland Shelf: a Comparison of Two Reanalysis Products by Vianco, Sara L.

“…The EGCC in RARE is primarily buoyancy-driven, though the along-coast winds likely play a major role in maintaining the density front that supports the EGCC. …”
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The level of knowledge, attitude and practice towards Covid-19 immunisation among medical students in public medical schools in Malaysia by Mohamad Zainal, Nurul Hayati, Mohammed Ayyub, Safiyya, Yi, Chang Fang, Zaman, Arif Najmi Shahrir, Mohd Nor, Nurul Huda, Omar, Norsuhana, Ku Mohd Noor, Ku Mastura, Hamimi Wahid, Hanan

“…From the total of 427 respondents, 60.2 had good knowledge whereby clinical students 67.0 had a higher proportion of good knowledge as compared to preclinical students 53.5 (p = 0.004). Respondents in the age group of 21 to 24 years old (p < 0.001) and 25 to 29 years old (p = 0.016), and Indian ethnicity (p = 0.006) were more likely to have good knowledge. …”
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Next-generation transgenic mice for optogenetic analysis of neural circuits by Feng, Guoping, Asrican, Brent, Augustine, George J., Berglund, Ken, Chen, Susu, Chow, Nick, Gloss, Bernd, Deisseroth, Karl, Mancuso, James, Hira, Riichiro, Hoffmann, Carolin, Tan, Gregory, Kasai, Haruo, Katarya, Malvika, Kim, Jinsook, Kudolo, John, Lee, Li Ming, Lo, Shun Qiang, Matsuzaki, Masanori, Nakajima, Ryuichi, Qiu, Li, Tang, Yanxia, Ting, Jonathan T., Tsuda, Sachiko, Wen, Lei, Zhang, Xuying, Zhao, Shengli

“…Here we characterize several new lines of transgenic mice useful for optogenetic analysis of brain circuit function. …”
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Online arts and culture for mental health in young people: a qualitative interview study by Syed Sheriff, R, Bergin, L, Bonsaver, L, Riga, E, O'Dell, B, Adams, H, Glogowska, M

“…Participants described that human connection was the feature of OAC most likely to benefit mental health and emphasised the importance of representation. …”

Delay-and-pay: prolonging pharmaceutical patent protection without paying the ‘price’ by Foss-Solbrekk, K

“…My doctrinal analysis establishes that the generic/biosimilar defendants’ loss is likely undercompensated and the money that national health authorities spent purchasing the more expensive, patented drug whilst the interim injunction remained in effect is not usually compensated following a patent revocation and discharged injunction. …”

Molluscum contagiosum and associations with atopic eczema in children: a retrospective longitudinal study in primary care by Olsen, JR, Piguet, V, Gallacher, J, Francis, NA

“…Children were found to be more likely to have an MC consultation if they had previously consulted a GP with AE (OR 1.13; 95% CI = 1.11 to 1.16; P<0.005).…”

Canadians' opinions towards COVID-19 data-sharing: a national cross-sectional survey by Savić Kallesøe, SA, Rabbani, T, Gill, EE, Brinkman, F, Griffiths, EJ, Zawati, M, Liu, H, Palmour, N, Joly, Y, Hsiao, WWL

“…Vaccination status was the most influential predictor of data-sharing opinion, with respondents who were ever vaccinated being 4.20 times more likely (95% CI 3.21 to 5.48, p=0.000) to be generally supportive of data-sharing than those unvaccinated. …”

The effect of pH on the production and composition of short- and medium-chain fatty acids from food waste in a leachate bed reactor at room temperature by Radadiya, Pooja, Latika, Ashika, Fei, Xunchang, Lee, Jangho, Mishra, Saurabh, Hussain, Abid

“…This study evaluated the hydrolysis and acidogenesis of food waste at different operating pHs (uncontrolled, 5.5, 6.5, 7.5, 8.5) in a leachate bed reactor (LBR) at room temperature. …”
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MAAD: A Model and Dataset for "Attended Awareness" in Driving by Gopinath, Deepak, Rosman, Guy, Stent, Simon, Terahata, Katsuya, Fletcher, Luke, Argall, Brenna, Leonard, John

“…In order to test our model, we capture a new dataset with a high-precision gaze tracker including 24.5 hours of gaze sequences from 23 subjects attending to videos of driving scenes. …”
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Self-Assembly of Semiconducting Polymer Amphiphiles for In Vivo Photoacoustic Imaging by Xie, Chen, Zhen, Xu, Lei, Qunli, Ni, Ran, Pu, Kanyi

“…Despite the advantages of semiconducting polymer nanoparticles (SPNs) over other inorganic nanoparticles for photoacoustic (PA) imaging, their synthetic method is generally limited to nanoprecipitation, which is likely to cause the issue of nanoparticle dissociation. …”
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Immune Checkpoint Blockade sensitivity and Progression-Free Survival associates with baseline CD8+ T cell clone size and cytotoxicity by Watson, R, Tong, O, Taylor, C, Kumar Sharma, P, Verge De Los Aires, A, Mahe, E, Ruffieux, H, Nassiri, I, Middleton, M, Fairfax, B

“…Cytotoxic effector clones were more likely to persist long-term following ICB and overlapped with public tumour-infiltrating lymphocyte clonotypes. …”

Insights from an Experiment Crowdsourcing Data from Thousands of US Amazon Users: The importance of transparency, money, and data use by Berke, Alex, Mahari, Robert, Pentland, Sandy, Larson, Kent, Calacci, Dana

“…This paper shares an innovative approach to crowdsourcing user data to collect otherwise inaccessible Amazon purchase histories, spanning 5 years, from more than 5,000 U.S. users. We developed a data collection tool that prioritizes participant consent and includes an experimental study design. …”
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Quality seaport : model building and empirical validation by Phang, Louise Foong Hung.

“…The survey was sent out to a total of 350 Freight Forwarders, Shipping Lines and Cargo Owners who are main users of the Singapore Port that we are focusing our study on for simplification purposes. …”
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Injectable cell transplantation system for cytokine-based cancer immunotherapy by Gerard Nathanael Adrianus.

“…The construct was able to exert toxicity to two malignant cell lines, MCF-7 and HepG2, but no effect was observed in HeLa and H1229 cells. …”
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Evaluation and selection of rice mutants for high yield and quality fodder production by Abisola, Oladosu Yusuff

“…Evaluation over two locations, mutant lines ML21, ML10, ML4, ML6 and ML9 performed better in terms of yield production compared to other mutants. …”
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A 15-year review of dengue hospitalizations in Singapore : reducing admissions without adverse consequences, 2003 to 2017 by Ang, Li Wei, Thein, Tun-Linn, Ng, Yixiang, Boudville, Irving Charles, Chia, Po Ying, Lee, Vernon Jian Ming, Leo, Yee-Sin

“…Further studies are needed to optimize dengue management in older adults who are more likely to be hospitalized with greater disease severity, given the higher proportions of hospitalizations and severe disease among older adults.…”
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16.31 Feedback Control Systems, Fall 2001 by How, Jonathan P.

“…By the end of the course, students should be able to design controllers using state-space methods and evaluate whether these controllers are "robust," that is, if they are likely to work well in practice.…”
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