Exploring the therapeutic potential of 5-fluorouracil-loaded calcium carbonate nanoparticles combined with natural compound thymoquinone for colon cancer treatment by Deng, Xi, Yang, Zhongming, Chan, Kim Wei, Abu Bakar, Md Zuki

“…These results provide evidence for 5FU-CaCO3np as a novel regimen against colon cancer. Combining 5FU-CaCO3np and TQ may offer a new perspective for colon cancer therapy.…”
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Rifaximin potentiates clarithromycin against Mycobacterium abscessus in vitro and in zebrafish by Goh, Boon Chong, Larsson, Simon, Dam, Linh Chi, Ling, Sharon Yan Han, Chua, Patrina Wei Lin, Abirami, R., Singh, Samsher, Ong, Ernest Jun Long, Teo, Jeanette W. P., Ho, Peiying, Ingham, Philip William, Pethe, Kevin, Dedon, Peter C.

“…Because of its extensive innate resistance to numerous antibiotics, treatment options are limited, often resulting in poor clinical outcomes. Current treatment regimens usually involve a combination of antibiotics, with clarithromycin being the cornerstone of NTM treatments.…”
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Exploring and Exploiting Ribonuclease 1: from Protein Biochemistry to Protein Engineering by Wralstad, Evans Christian

“…RNase 1 and its bovine homologue RNase A exhibit ubiquitous expression across tissues, a catalytic efficiency within the diffusion-limited regime, and minimal substrate sequence requirements. …”
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High cycle fatigue characterisation and modelling of 316L stainless steel processed by laser powder bed fusion by Zhang, Meng

“…In the presence of tensile mean stress, variations in the plastic deformation properties, as demonstrated by the effects of build orientation and post-processing treatments (annealing or hot isostatic pressing), were found to induce cyclic plasticity, which led to strong fatigue-ratcheting interactions in the high cycle fatigue regime. The simultaneous actions of ratcheting and fatigue generate complex nonlinear relationships between the stress amplitude and mean stress parameters, such that the fatigue properties could not be effectively predicted using traditional stress-based models. …”
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MCMC inversion of the transient and steady-state creep flow law parameters of dunite under dry and wet conditions by Masuti, Sagar, Barbot, Sylvain

“…For wet dunites in the grain-boundary sliding regime, the grain-size dependence is similar for transient creep and steady-state creep. …”
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Institutions and agricultural transformation: a study of induced innovation in the Philippine rice sector by Montesclaros, Jose Ma. Luis P.

“…Research findings supported the hypotheses that agricultural transformation was impeded by the three factors: 1) an industrialisation-inspired de-facto currency overvaluation regime removed farmers’ potential to capture export markets, the latter serving as a “carrot” for adopting innovation; 2) trade protectionist policies in the rice sector removed import competition as a “stick” for adopting innovation; and 3) industrialisation- and land reform-related capital scarcity among smallholder farmers hindered the dynamics of IIA from taking place. …”
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Free-electron crystals for enhanced X-ray radiation by Wong, Wesley Lee Wei, Shi, Xihang, Karnieli, Aviv, Lim, Jeremy, Kumar, Suraj, Carbajo, Sergio, Kaminer, Ido, Wong, Liang Jie

“…Our work highlights an unprecedented regime of free electron light emission where electron waveshaping provides multi-dimensional control over practical radiation processes like bremsstrahlung. …”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by McIlroy, G, Gaskell, C, Jackson, A, Yafai, E, Tasker, R, Thomas, C, Fox, S, Boucher, R, Ghebretinsea, F, Harrison, C, Mead, AJ, McMullin, MF

“…FEDORA uses a within-patient dose escalation regimen to ensure each patient reaches a personalised dose combination that is acceptable. …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Notably, 42.9% of the participants with known hypertension did not adhere to their antihypertensive medication regimen, citing cost, availability, side effects, and forgetfulness as common reasons. …”

GPU-Oriented Algorithms for Continuous Energy Monte Carlo Neutron Transport by Ridley, Gavin

“…Through three asymptotic arguments covering different resonant behavior regimes, we show that the normal inverse Gaussian distribution is the natural choice for modeling the total neutron cross-section distribution. …”
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Ultrafast dynamics in quantum materials probed by time-and-momentum-resolved techniques by Su, Yifan

“…Coherent phonons and CDW systems are two of the richest playgrounds in the ultrafast regime. I am going to investigate various cases where an ultrafast laser pulse decodes the intertwined degrees of freedom in quantum materials. …”
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Sociospatial reframing of walking through inclusive streets and urban heritage by Wang, Yongcheng

“…The inclusive street design regime was also found to be compatible with the notion of urban heritage in a meta-narrative review to explore the potential of urban heritage being repositioned for urban and transport planning in which the promotion of walking is a high priority. …”
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Exciton polariton interactions in Van der Waals superlattices at room temperature by Zhao, Jiaxin, Fieramosca, Antonio, Dini, Kevin, Bao, Ruiqi, Du, Wei, Su, Rui, Luo, Yuan, Zhao, Weijie, Sanvitto, Daniele, Liew, Timothy Chi Hin, Xiong, Qihua

“…The integration of TMD heterostructures in planar microcavities working in strong coupling regime is particularly important to control the light-matter interactions and form robust polaritons, highly sought for room temperature applications. …”
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Evaluation of subconjunctival liposomal steroids for the treatment of experimental uveitis by Wong, Chee Wai, Czarny, Bertrand, Metselaar, Josbert M., Ho, Candice, Ng, Si Rui, Barathi, Amutha Veluchamy, Storm, Gert, Wong, Tina T.

“…The current gold standard for treatment is topical steroids, but low ocular bioavailability and compliance issues with the intensive dosing regimen limit the efficacy of this treatment. Liposomes as a drug delivery system may help to overcome these problems. …”
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Repurposing nitroxoline to address antibiotic resistance in the production of poultry for consumption by Zhou, Y

“…<em>In-vivo</em> evaluation (Chapter 5) established an optimal dosage regimen (100 mg/kg of NTX in feed) for treating <em>Salmonella</em> infections in poultry without promoting the development of resistance. …”

Cytisine versus varenicline for smoking cessation in a primary care setting: a randomized non-inferiority trial by Oreskovic, T, Percac-Lima, S, Ashburner, JM, Tiljak, H, Rifel, J, Klemenc Ketiš, Z, Oreskovic, S

“…Given the much lower cost of cytisine treatment, its lower rate of adverse events, and higher feasibility (but its likely lower effectiveness with the standard dosage regimen), future analyses should assess the cost-effectiveness of the two treatments for health policy considerations.…”

Hepatic effects of prolonged oral administration of Aqueous extracts from Trigonella foenum-graecum (Fenugreek) seeds explored through pathology techniques by Okorie, Nnaemeka, Ibe, Onyekachi Ewa, Okekpa, Simon Imakwu, Nwakpa, Anthony Chukwudi, Agom, Dansy Daniel, Pauline, Iyke-Ogbo, Adaeze, Obi Laura, Mmesomachi, Uche Bethel, Nyirahafashimana, Valentine, Obi, Ihuoma A.

“…Materials and methods: Thirty-five Norvegicus rattus weighing 150-200g were randomly assigned to five groups, with each subjected to distinct dietary regimens containing 2%, 4%, 6%, and 8% Trigonella foenum-graecum, and a control group. …”
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Association of nucleoside reverse transcriptase inhibitors with adverse perinatal outcomes in pregnant women living with HIV: systematic review and meta-analysis by Cowdell, I, Beck, K, Hey, M, Portwood, C, Sexton, H, Kumarendran, M, Brandon, Z, Kirtley, S, Hemelaar, J

“…</p> <br> <p><strong>Interventions:</strong> ART regimes containing different NRTI drugs.</p> <br> <p><strong>Assessment of risk of bias:</strong> Newcastle-Ottawa Scale and GRADE.…”

Dynamic fracture mechanics of FRP-concrete interface by Li, Gen

“…It was found that the two bond properties were close to those of plain concrete in the quasi-static regime and showed significant dynamic enhancing effect at a loading rate of 20 mm/s. …”
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Dimensionality-dependent type-II Weyl semimetal state in Mo₀.₂₅W₀.₇₅Te₂ by Li, Peiling, Deng, Ya, Hsu, Chuang-Han, Zhu, Chao, Cui, Jian, Yang, Xue, Zhou, Jiadong, Hung, Yi-Chun, Fan, Jie, Ji, Zhongqing, Qu, Fanming, Shen, Jie, Yang, Changli, Jing, Xiunian, Lin, Hsin, Liu, Zheng, Lu, Li, Liu, Guangtong

“…Here, by selecting a special sample with the thickness gradient across two- (2D) and three-dimensional (3D) regime, we show strong evidences that Mo$_{0.25}$W$_{0.75}$Te$_{2}$ is a type-II Weyl semimetal by observing the following two dimensionality-dependent transport features: 1) A chiral-anomaly-induced anisotropic magneto-conductivity enhancement, proportional to the square of in-plane magnetic field (B$_{in}$$^{2}$); 2) An additional quantum oscillation with thickness-dependent phase shift. …”
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