Clinical outcomes and adverse events of bariatric surgery in adults with severe obesity in Scotland: the SCOTS observational cohort study по Ruth M Mackenzie, Abdulmajid Ali, Duff Bruce, Julie Bruce, Ian Ford, Nicola Greenlaw, Eleanor Grieve, Mike Lean, Robert S Lindsay, Joanne O’Donnell, Naveed Sattar, Sally Stewart, Jennifer Logue

“...They spent longer in hospital after surgery and were more likely to be readmitted to hospital. How many appointments they had or what type of health professional they saw before or after surgery did not change these results. ...”
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Optimisation of the deployment of automated external defibrillators in public places in England по Terry P Brown, Lazaros Andronis, Asmaa El-Banna, Benjamin KH Leung, Theodoros Arvanitis, Charles Deakin, Aloysius N Siriwardena, John Long, Gareth Clegg, Steven Brooks, Timothy CY Chan, Steve Irving, Louise Walker, Craig Mortimer, Sandra Igbodo, Gavin D Perkins

“...AEDs need to be placed intelligently in public settings so that they are likely to be used by bystanders. We have developed a data-driven framework to support public-access AED location decisions, using optimisation and statistical models. ...”
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A‌S‌S‌E‌S‌S‌M‌E‌N‌T O‌F S‌T‌E‌E‌L S‌T‌R‌U‌C‌T‌U‌R‌E‌S W‌I‌T‌H A D‌U‌A‌L S‌Y‌S‌T‌E‌M O‌F M‌O‌M‌E‌N‌T F‌R‌A‌M‌E W‌I‌T‌H C‌O‌N‌C‌E‌N‌T‌R‌I‌C‌A‌L‌L‌Y B‌R‌A‌C‌E I‌N‌F‌L‌U‌E‌N‌C‌I‌N‌G R‌... по N. Jahan, A.M. Heydari Tafreshi, M. Gerami

“...I‌n t‌h‌e s‌e‌i‌s‌m‌i‌c a‌c‌t‌i‌v‌e z‌o‌n‌e‌s, s‌t‌r‌u‌c‌t‌u‌r‌e‌s a‌r‌e l‌i‌k‌e‌l‌y t‌o b‌e s‌u‌b‌j‌e‌c‌t t‌o m‌u‌l‌t‌i‌p‌l‌e e‌a‌r‌t‌h‌q‌u‌a‌k‌e‌s d‌u‌e t‌o t‌h‌e c‌o‌m‌p‌l‌e‌x s‌t‌r‌e‌s‌s i‌n‌t‌e‌r‌a‌c‌t‌i‌o‌n‌s a‌m‌o‌n‌g t‌h‌e t‌e‌c‌t‌o‌n‌i‌c p‌l‌a‌t‌e‌s. ...”
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Take-home naloxone in multicentre emergency settings: the TIME feasibility cluster RCT по Helen Snooks, Jonathan Benger, Fiona Bell, Sarah Black, Simon Dixon, Helena Emery, Bridie Angela Evans, Gordon Fuller, Rebecca Hoskins, Jane Hughes, Jenna Jones, Matthew Jones, Sasha Johnston, Jaqui Long, Chris Moore, Rakshita Parab, Richard Pilbery, Fiona C Sampson, Alan Watkins

“...Other patients left before receiving a kit. Service users liked the idea of take-home naloxone kits being provided in the emergency setting but reported resistance to attending hospital following an overdose. ...”
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Does nicotine replacement therapy affect the frequency of delirium in patients after isolated myocardial revascularization? [Full text in English] по V. V. Bazylev, M. E. Evdokimov, A. A. Gornostaev, I. S. Fomina, A. A. Schegolkov, A. V. Bulygin, E. A. Malyarova

“...<em>EuroSCORE,</em> European System for Cardiac Operative Risk Evaluation;<em> NYHA</em>, The New York Heart Association</p><p><strong><img src="/public/site/images/kulinich/Table_23.jpg" alt="" /></strong></p><p><em>ICU, </em>intensive care unit</p><p><strong>Discussion</strong></p><p>Delirium is not an isolated pathology. It is highly likely a symptom of central nervous system damage, polyetiological in its nature. ...”
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Identify the Factors Affecting the Transition of Necessity Female Nascent Entrepreneurs to Established Entrepreneurship по Reza Kohanhooshnejad, Seyedeh Zahra Mousavi

“...The realization of these consequences for necessity female nascent entrepreneurs will likely lead to their transition to established entrepreneurship, thereby having positive effects on economic growth and development. ...”
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Use of selective gut decontamination in critically ill children: PICnIC a pilot RCT and mixed-methods study по Alanna Brown, Paloma Ferrando-Vivas, Mariana Popa, Gema Milla de la Fuente, John Pappachan, Brian H Cuthbertson, Laura Drikite, Richard Feltbower, Theodore Gouliouris, Isobel Sale, Robert Shulman, Lyvonne N Tume, John Myburgh, Kerry Woolfall, David A Harrison, Paul R Mouncey, Kathryn Rowan, Nazima Pathan

“...Children who were recruited to the PICnIC study were representative of similar potentially eligible patients in the study PICUs and all UK PICUs but were more likely to be male (62% vs. 56%) and with a primary diagnosis of infection (12.8% vs. 7%) when compared with all UK PICUs. ...”
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Strategies for older people living in care homes to prevent urinary tract infection: the StOP UTI realist synthesis по Jacqui Prieto, Jennie Wilson, Alison Tingle, Emily Cooper, Melanie Handley, Jo Rycroft-Malone, Jennifer Bostock, Lynne Williams, Heather Loveday

“...A mixture of purposive and convenience sampling was used to gain perspectives from individuals reflective of the different audiences likely to be interested in acting on the findings from this review. ...”
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Automated devices for identifying peripheral arterial disease in people with leg ulceration: an evidence synthesis and cost-effectiveness analysis по Dwayne Boyers, Moira Cruickshank, Lorna Aucott, Charlotte Kennedy, Paul Manson, Paul Bachoo, Miriam Brazzelli

“...The decision to structure the mixed Markov model similarly to the arterial-only model was based on discussion with clinical experts who explained that, in clinical practice, the arterial component of disease is likely to take priority in the patient’s care pathway. ...”
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A cloud-based medical device for predicting cardiac risk in suspected coronary artery disease: a rapid review and conceptual economic model по Marie Westwood, Nigel Armstrong, Eline Krijkamp, Mark Perry, Caro Noake, Apostolos Tsiachristas, Isaac Corro-Ramos

“...When offering treatment, specialist heart doctors are likely to consider a person’s symptoms and other risk factors (such as family history of heart disease, diabetes and smoking history), as well as how much narrowing of the arteries has happened. ...”
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The efficacy of sildenafil therapy in dismal prognosis early-onset intrauterine growth restriction: the STRIDER RCT по Andrew Sharp, Christine Cornforth, Richard Jackson, Jane Harrold, Mark A Turner, Louise Kenny, Philip N Baker, Edward D Johnstone, Asma Khalil, Peter von Dadelszen, Aris T Papageorghiou, Brigitte Vollmer, Zarko Alfirevic

“...On current evidence, the researchers do not believe that there is likely to be any beneficial effect on fetal growth, perinatal outcomes or neurodevelopment in this patient group and would advise that further use of sildenafil in this population should be stopped. ...”
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Impact of interventions to improve recovery of older adults following planned hospital admission on quality-of-life following discharge: linked-evidence synthesis по Debbie Kinsey, Samantha Febrey, Simon Briscoe, Dylan Kneale, Jo Thompson Coon, Daniele Carrieri, Christopher Lovegrove, John McGrath, Anthony Hemsley, GJ Melendez-Torres, Liz Shaw, Michael Nunns

“...These patients are more likely to experience difficulties, such as urinary infections or falls, whilst in hospital, so should not spend more time in hospital than necessary. ...”
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Cognitive remediation therapy to enhance cognition and improve recovery in early psychosis: the ECLIPSE research programme including an RCT по Til Wykes, Eileen Joyce, Emese Csipke, Dominic Stringer, Andrew Pickles, Paul McCrone, Matteo Cella, Rumina Taylor, Rose Tinch-Taylor, Janet Boadu, Gregory Aarons, Max Birchwood, Sue Dopson, David Fowler, Kathryn Greenwood, Sonia Johnson, Jesus Perez, Rosa Ritunnano, Andrew Thompson, Rachel Upthegrove, Jon Wilson, Clare Reeder

“...Overall, cognitive remediation was acceptable and well liked by service users, so all our data suggest that it should be more easily accessible in the National Health Service. ...”
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Revisiting the Ethical Framework Governing Water Fluoridation and Food Fortification по Ahmad Shakeri, Howsikan Kugathasan

“...Ginter et al. strongly suggested that statins should not be added to public water supplies as they will most likely cause detrimental health effects to those not suffering from high cholesterol or heart disease [5]. ...”
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Prehospital early warning scores for adults with suspected sepsis: the PHEWS observational cohort and decision-analytic modelling study по Steve Goodacre, Laura Sutton, Kate Ennis, Ben Thomas, Olivia Hawksworth, Khurram Iftikhar, Susan J Croft, Gordon Fuller, Simon Waterhouse, Daniel Hind, Matt Stevenson, Mike J Bradburn, Michael Smyth, Gavin D Perkins, Mark Millins, Andy Rosser, Jon Dickson, Matthew Wilson

“...Most early warning scores, used at a recommended threshold, are likely to prioritise an unmanageable number of cases unless they are only used to prioritise cases with a paramedic diagnostic impression of infection or sepsis. ...”
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The Resilience Hub approach for addressing mental health of health and social care workers during the COVID-19 pandemic: a mixed-methods evaluation по Filippo Varese, Kate Allsopp, Lesley-Anne Carter, Gemma Shields, Daniel Hind, Linda Davies, Alan Barrett, Gita Bhutani, Katherine McGuirk, Fay Huntley, Joanne Jordan, Aleix Rowlandson, May Sarsam, Hein Ten Cate, Holly Walker, Ruth Watson, Jack Wilkinson, Jenni Willbourn, Paul French

“...Keyworkers were more likely to access Hub support when they understood it, differentiated it from other types of support, and felt supported by managers to access it. ...”
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Clinical and cost‐effectiveness of pessary self‐management versus clinic-based care for pelvic organ prolapse in women: the TOPSY RCT with process evaluation по Carol Bugge, Suzanne Hagen, Andrew Elders, Helen Mason, Kirsteen Goodman, Melanie Dembinsky, Lynn Melone, Catherine Best, Sarkis Manoukian, Lucy Dwyer, Aethele Khunda, Margaret Graham, Wael Agur, Suzanne Breeman, Jane Culverhouse, Angela Forrest, Mark Forrest, Karen Guerrero, Christine Hemming, Doreen McClurg, John Norrie, Ranee Thakar, Rohna Kearney

“...Future research on pessary self-management is needed to look at possible links between pessary continuation and complications, including which specific complications are more likely to lead to discontinuation. Study registration This study is registered as ISRCTN62510577. ...”
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Posterior cervical foraminotomy versus anterior cervical discectomy for Cervical Brachialgia: the FORVAD RCT по Simon Thomson, Gemma Ainsworth, Senthil Selvanathan, Rachel Kelly, Howard Collier, Ruben Mujica-Mota, Rebecca Talbot, Sarah Tess Brown, Julie Croft, Nikki Rousseau, Ruchi Higham, Yahia Al-Tamimi, Neil Buxton, Nicholas Carleton-Bland, Martin Gledhill, Victoria Halstead, Peter Hutchinson, James Meacock, Nitin Mukerji, Debasish Pal, Armando Vargas-Palacios, Anantharaju Prasad, Martin Wilby, Deborah Stocken

“...The corresponding median scores were 0.210 (IQR –0.01 to 0.60) and 0.689 (IQR 0.66–0.69). This is likely to have played a role in the larger observed gains from baseline in postoperative EuroQol-5 Dimensions (EQ-5D) scores for participants in the PCF group than in the ACD group [median change at 6 weeks of 0.10 (IQR 0.00–0.13) and 0.02 (IQR –0.03 to 0.06), respectively]. ...”
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The effects and safety of testosterone replacement therapy for men with hypogonadism: the TestES evidence synthesis and economic evaluation по Moira Cruickshank, Jemma Hudson, Rodolfo Hernández, Magaly Aceves-Martins, Richard Quinton, Katie Gillies, Lorna S Aucott, Charlotte Kennedy, Paul Manson, Nicholas Oliver, Frederick Wu, Siladitya Bhattacharya, Waljit S Dhillo, Channa N Jayasena, Miriam Brazzelli

“...New studies are needed to find out whether some groups of men (such as older or younger men) are more likely to benefit from testosterone replacement therapy more than others. ...”
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Immunogenicity and seroefficacy of pneumococcal conjugate vaccines: a systematic review and network meta-analysis по Shuo Feng, Julie McLellan, Nicola Pidduck, Nia Roberts, Julian PT Higgins, Yoon Choi, Alane Izu, Mark Jit, Shabir A Madhi, Kim Mulholland, Andrew J Pollard, Simon Procter, Beth Temple, Merryn Voysey

“...Our results using individual-level data from a global meta-analysis provide the first estimates of the comparative protection afforded by different pneumococcal vaccines and show that for many serotypes, carriage events are less common after PCV13 than PCV10, likely due to a higher antibody response. In addition, we quantify the relationship between the immune response to vaccination and protection against infection, measured serologically, and show that higher antibody responses in infants are associated with greater protection from infection. ...”
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