Showing 1,021 - 1,040 results of 7,888 for search '(((((spinala OR (spinae OR sspinae)) OR binaa) OR min) OR (find OR pinned)) OR (yong OR link))', query time: 0.21s Refine Results
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    The novel quinoline derivative SKA-346 as a KCa3.1 channel selective activator by Wong, Brandon Han Siang, Shim, Heesung, Goay, Stephanie Shee Min, Ong, Seow Theng, Nur Ayuni Binte Muhammad Taib, Chai, Kelila Xin Ye, Lim, Kerry, Huang, Dachuan, Ong, Choon Kiat, Vaiyapuri, Thamil Selvan, Cheah, Yeong Cheng, Wang, Yulan, Wulff, Heike, Webster, Richard David, Shelat, Vishalkumar G., Verma, Navin Kumar

    Published 2025
    “…SKA-346 (30 mg kg-1), tolerated by mice after intra-peritoneal administration, exhibited a peak plasma concentration of 6.29 μg mL-1 (29.2 μM) at 15 min and a circulating half-life (t 1/2) of 2.8 h. …”
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    Journal Article
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    Materials cartography: A forward-looking perspective on materials representation and devising better maps by Torrisi, Steven B., Bazant, Martin Z., Cohen, Alexander E., Cho, Min Gee, Hummelshøj, Jens S., Hung, Linda, Kamat, Gaurav, Khajeh, Arash, Kolluru, Adeesh, Lei, Xiangyun, Ling, Handong, Montoya, Joseph H., Mueller, Tim, Palizhati, Aini, Paren, Benjamin A., Phan, Brandon, Pietryga, Jacob, Sandraz, Elodie, Schweigert, Daniel, Shao-Horn, Yang, Trewartha, Amalie, Zhu, Ruijie, Zhuang, Debbie, Sun, Shijing

    Published 2024
    “…We present several promising directions for future research: devising representations of varied experimental conditions and observations, the need to find ways to integrate machine learning into laboratory practices, and making multi-scale informatics toolkits to bridge the gaps between atoms, materials, and devices.…”
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    Article
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    Mitofusins Mfn1 and Mfn2 are required to preserve glucose- but not incretin-stimulated β-cell connectivity and insulin secretion by Georgiadou, Eleni, Muralidharan, Charanya, Martinez, Michelle, Chabosseau, Pauline, Akalestou, Elina, Tomas, Alejandra, Yong, Fiona Su Wern, Stylianides, Theodoros, Wretlind, Asger, Legido-Quigley, Cristina, Jones, Ben, Lopez-Noriega, Livia, Xu, Yanwen, Gu, Guoqiang, Alsabeeh, Nour, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Ali, Yusuf, Soleimanpour, Scott A., Linnemann, Amelia K., Rodriguez, Tristan A., Rutter, Guy A.

    Published 2022
    “…Mitochondrial fusion and fission cycles are thus essential in the β-cell to maintain normal glucose, but not incretin, sensing. These findings broaden our understanding of the roles of mitofusins in β-cells, the potential contributions of altered mitochondrial dynamics to diabetes development, and the impact of incretins on this process.…”
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    Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study by Suphavilai, Chayaporn, Ko, Karrie Kwan Ki, Lim, Kar Mun, Tan, Mei Gie, Boonsimma, Patipan, Chu, Joash Jun Keat, Goh, Sui Sin, Rajandran, Prevena, Lee, Lai Chee, Tan, Kwee Yuen, Bushra Binte Shaik Ismail, Aung, May Kyawt, Yang, Yong, Sim, Jean Xiang Ying, Venkatachalam, Indumathi, Cherng, Benjamin Pei Zhi, Spruijtenburg, Bram, Chan, Kian Sing, Oon, Lynette Lin Ean, Tan, Ai Ling, Tan, Yen Ee, Wijaya, Limin, Tan, Ban Hock, Ling, Moi Lin, Koh, Tse Hsien, Meis, Jacques F., Tsui, Clement Kin Ming, Nagarajan, Niranjan

    Published 2024
    “…We further implemented Bayesian logistic regression models to classify isolates into known clades and simulate the automatic detection of isolates belonging to novel clades as their WGS data became available. Findings: The three investigated isolates were separated by at least 37 000 SNPs (range 37 000–236 900) from all existing C auris clades. …”
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