Enhanced expression of codon optimized interferon gamma in CHO cells by Yusufi, Faraaz N. K., Yang, Yuansheng, Lee, Dong-Yup, Chung, Bevan Kai-Sheng, Mariati

“…However, our RNA-Seq based transcriptome profiling indicated that the ICU and CC distribution patterns of different gene expression classes in CHO cell are relatively similar, unlike other microbial expression hosts, Escherichia coli and Saccharomyces cerevisiae. This finding was further corroborated through the in vivo expression of various ICU and CC optimized IFN-γ in CHO cells. …”
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Colloidal semiconductor nanocrystals for light-emitting devices : from materials to device perspectives by Shendre, Sushant

“…The results found in this work nudge the direction of future research towards the mitigation of the disadvantages posed by Auger processes in QLED operation. The findings of this thesis indicate that the synthesis of advanced nanocrystals and understanding of their active device operation will enable us to make high-efficiency colloidal devices to compete as an alternative to their thin-film counterparts.…”
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Surface-Enhanced Raman Scattering (SERS) of Nitrothiophenol isomers chemisorbed on TiO2 by Teguh, Jefri S., Liu, Fang, Xing, Bengang, Yeow, Edwin Kok Lee

“…The DFT calculation determined that the HOMO and the LUMO of NTP bound to TiO2 were located entirely on the adsorbate and the semiconductor, respectively, thereby supporting the experimental findings that a molecule-to-TiO2 mechanism was the driving force behind the observed SERS effect.…”
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Genome-wide gene expression profiling of the Angelman syndrome mice with Ube3a mutation by Low, Daren., Chen, Ken-Shiung.

“…Consistent with this finding, expression of small interfering RNA that targets Ube3a in P19 cells caused down-regulation of Mc1r and Nr4a2, whereas overexpression of Ube3a results in the up-regulation of Mc1r and Nr4a2 when compared to mock transfected cells. …”
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Metabolomic characterisation of low-density lipoproteins isolated from iodixanol and KBr-based density gradient ultracentrifugation by Webb, Richard, Lodge, John, Scott, Sophie, Davies, Ian

“…Differences were shown in the molecular composition of LDL prepared using SBUC and IGUC; in positive mode ionisation, the PLS-DA model showed reasonable fit and discriminatory power (R2 = 0.63, Q2 = 0.58, accuracy 0.88) and permutation testing was significant (p < 0.001). Conclusions: The findings reveal distinct differences in the small molecule composition of LDL prepared using the two methods, with IGUC exhibiting greater variation. …”
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Advancing cyber incident timeline analysis through retrieval-augmented generation and large language models by Loumachi, Fatma Yasmine, Ghanem, Mohamed Chahine, Ferrag, Mohamed Amine

“…The proposed framework was tested on synthetic cyber incident events in a controlled environment, with results assessed using DFIR-tailored, context-specific metrics designed to evaluate the framework’s performance, reliability, and robustness, supported by human evaluation to validate the accuracy and reliability of the outcomes. Our findings demonstrate the practical power of LLMs in advancing the automation of cyber-incident timeline analysis, a subfield within DFIR. …”
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The great problems are in the street : a phenomenology of men's stranger intrusions on women in public spaces by Vera-Gray, Fiona

“…Firstly it develops the reciprocal practice of translating philosophy into the vernacular of women’s experiences of VAWG, finding that a philosophical perspective assists a feminist reframing of medical/legal models of VAWG. …”
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A pilot study on peptidylarginine deiminases and protein deimination in animal cancers across vertebrate species by Inal, Jameel, Hristova, Mariya, Lange, Sigrun

“…Both PAD2 and PAD3 were the most predominantly expressed PADs across all of the cancers assessed, while PAD1, PAD4, and PAD6 were overall expressed at lower, albeit varying, levels. The findings from this pilot study provide novel insights into PAD-mediated roles in different cancers across a range of vertebrate species and may aid in the understanding of cancer heterogeneity and cancer evolution.…”
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Sustainable performance through digital supply chains in industry 4.0 era: amidst the pandemic experience by Joshi, Sudhanshu, Sharma, Manu

“…The study calls for firms to employ multiple DSCs once they have set clear strategic priorities. The overall findings of the work fill the literature gaps of studies in the digitalization of supply chains.…”
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How counselling psychologists address issues of race with clients from black Asian and minority ethnic backgrounds: a discourse analysis by Madre de Deus de Sousa, Filipe Alexandre, Banbury, Samantha, Phillips, Olaide, Lusher, Joanne

“…The first two discourses alluded to similar repertoires present in the discussions of white counselling psychologist participants, whereas the discourse challenging systemic racism was constructed by BAME counselling psychologists. Findings indicate that becoming attuned and open to discussing race-related difficulties supports favorable outcomes in practice when engaging with BAME individuals. …”
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The relationship between the moderate–heavy boundary and critical speed in running by Hunter, Ben, Meyler, Samuel, Maunder, Ed, Cox, Tobias H., Muniz-Pumares, Daniel

“…Conclusions: The study highlights some uncertainty in the fraction of T1 relative to CS, influenced by inconsistent approaches in determining both boundaries. However, our findings serve as a foundation for remote analysis and prescription of exercise intensity, although testing is recommended for more precise applications.…”
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Accelerating black objects and their holographic duals by Boido, A

“…</p> <p>We illustrate our findings with many examples throughout, including an explicit solution obtained in 5d STU gauged supergravity and uplifted on a five-sphere.…”

Agamben's understanding of time and its implications for Christology by Wright, O

“…But in the case of Agamben’s work, the discussion of temporality finds a new form of textual presentation: Agamben seeks to orchestrate other ‘texts’ (St Paul’s letters, Franciscan Rules of Life, poetry, art) to create an experience in his reader of his understanding of time. …”

Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood by Rammos, A, Sullivan, SA, Kounali, D, Jones, HJ, Hammerton, G, Hines, LA, Lewis, G, Jones, PB, Cannon, M, Thompson, A, Wolke, D, Heron, J, Zammit, S

“…</p> <br> <p><strong>Conclusions:</strong> These findings indicate that the same risk factors are associated with incidence as with persistence of psychotic experiences. …”

A comparative analysis of vitrification and two slow freezing methods for gonocyte-containing neonatal calf testicular tissue and subsequent in vitro culture by Tang, S, Jones, C, Davies, J, Lane, S, Coward, K

“…Collectively, these findings propose vitrification as a promising alternative cryopreservation method for immature testicular tissue (ITT) in clinical applications. …”

Pan-European atmospheric lead pollution, enhanced blood lead levels, and cognitive decline from Roman-era mining and smelting by McConnell, JR, Chellman, N, Plach, A, Wensman, SM, Plunkett, G, Stohl, A, Smith, N, Vinther, BM, Dahl-Jensen, D, Steffensen, JP, Fritzsche, D, Brugger, SO, McDonald, BT, Wilson, AI

“…Here we determined potential health effects of this air pollution using Arctic ice core measurements of Roman-era lead pollution, atmospheric modeling, and modern epidemiology-based relationships between air concentrations, blood lead levels, and cognitive decline. Findings suggest air lead concentrations exceeded 150 ng/m3 near metallurgical emission sources, with average enhancements of &gt;1.0 ng/m3 over Europe during the Pax Romana apogee of the Roman Empire. …”

Hormone replacement therapy and cancer survival: a longitudinal cohort study: protocol paper by Ranger, TA, Burchardt, J, Clift, AK, Mei, WX, Coupland, C, Tan, PS, Dixon, S, Cardwell, CR, Hippisley-Cox, J

“…We intend to the submit the findings for peer-reviewed publication in an academic journal and disseminate them to the public through Cancer Research UK.…”

Factors influencing macrophage phagocytosis and killing of Gram negative bacteria by Kurzyp, K

“…I showed that the effect of the GPR84 agonist 6-OAU was GPR84 specific in murine macrophages; in human macrophages, all three novel agonists tested were GPR84 specific.</p> <p>My findings provide novel tools and insights into factors involved in the interaction of <em>N. gonorrhoeae</em> and <em>E. coli</em> with macrophages, and suggest how macrophage receptors could be exploited to enhance bacterial killing for immune adjuvant therapy of infection.…”

Mobilising stone: investigating relations of materiality, movement and corporality in Holocene Saharan rock-art by Waldock, V

“…</p> <p>Other significant findings include detailed information on the role and identity of the image-maker, revisionist data on the amount of effort and skill expended in carving processes, and an examination of the ways in which rock-art was used to manifest social emotional concerns. …”

Symptom flares in women with chronic pelvic pain: questionnaire study within a cohort study (translational research in pelvic pain (TRiPP)) by Coxon, L, Lugt, C, Horne, AW, Evans, E, Abreu- Mendes, P, Arendt-Nielsen, L, Aziz, Q, Becker, CM, Birch, J, Charrua, A, Demetriou, L, Ferreira-Gomes, J, Hoffman, A, Hummelshoj, L, Krassowski, M, Lunde, CE, Meijlink, J, Missmer, SA, Perro, D, Zondervan, KT, Sieberg, CB, Cruz, F, Nagel, J, Vincent, K

“…Clinical practice should include an enquiry into flares with the aim of finding strategies to lessen their burden.</p>…”