Factors influencing macrophage phagocytosis and killing of Gram negative bacteria by Kurzyp, K

“…</p> <p>Bacterial factors influencing gonococcal interactions with human macrophages have not been studied extensively. I investigated the impact of gonococcal LOS glycans on uptake of bacteria by macrophages. …”

Legitimate priority-setting: refining accountability for reasonableness and its application within NICE by Rand, L

“…<p>In this dissertation, I examine Daniels and Sabin’s theory for fair and legitimate procedures, accountability for reasonableness (AFR), and its relationship to the National Institute for Health and Care Excellence (NICE). AFR has been widely adopted as an exemplar model of procedural decision-making for healthcare limit-setting. …”

Most of the world's largest flowers (genus Rafflesia) are now on the brink of extinction by Malabrigo Jr, P, Tobias, AB, Witono, J, Mursidawati, S, Susatya, A, Siti-Munirah, MY, Wicaksono, A, Raihandhany, R, Edwards, S, Thorogood, CJ

“…<br><strong> Summary<br></strong> The genus Rafflesia, which includes the world's largest flowers, has aroused curiosity among scientists for centuries and features prominently in local culture across Southeast Asia. The plant has long been used in ethnobotanical medicine and, more recently, as a source of revenue from ecotourism. …”

Essays on the market for corporate bonds by Levonmaa, A

“…Realized measures of volatility have been shown to be important in modelling and forecasting equity, exchange rate, and Treasury bill return volatility. …”

Adaptation of the WHO AWaRe (Access, Watch, Reserve) antibiotic classification to support national antimicrobial stewardship priorities in the UK: findings from a modified Delphi a... by Bou-Antoun, S, Oettle, RC, Leanord, A, Seaton, RA, Cooper, BS, Muller-Pebody, B, Conlon-Bingham, G, Kerr, F, Hand, KS, Sandoe, JAT, Llewelyn, MJ, Fleming, N, Brown, NM, Reid, N, Howard, P, Mckinstry, S, Malcolm, W, Demirjian, A, Ashiru-Oredope, D

“…Conclusions: An adapted UK-AWaRe list has been suggested through a consensus-reaching process. …”

Long COVID and cardiovascular disease: a prospective cohort study by Lawson, CA, Moss, AJ, Arnold, JR, Bagot, C, Banerjee, A, Berry, C, Greenwood, J, Hughes, AD, Khunti, K, Mills, NL, Neubauer, S, Raman, B, Sattar, N, Leavy, OC, Richardson, M, Elneima, O, McAuley, HJ, Shikotra, A, Singapuri, A, Sereno, M, Saunders, R, Harris, V, Houchen-Wolloff, L, Greening, NJ, Harrison, E, Docherty, AB, Lone, NI, Quint, JK, Chalmers, J, Ho, L-P, Horsley, A, Marks, M, Poinasamy, K, Evans, R, Wain, LV, Brightling, C, McCann, GP

“…<p><strong>Background:</strong> Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known.…”

Genotype-phenotype maps for gene networks: from evolution to computation by Camargo, FQ

“…However, most of these properties have only been studied for self-assembling systems, such as protein complexes or RNA folding. …”

Understanding the disease mechanisms of cerebellar ataxia through induced pluripotent stem cell models by Wong, M

“…Although numerous causative genes have been identified, the underlying pathogenic mechanisms remain incompletely understood, due to the limited availability of human brain tissue and the lack of reliable disease models. …”

Barriers and opportunities for WHO ‘best buys’ non-communicable disease policy adoption and implementation from a political economy perspective: a complexity systematic review by Loffreda, G, Arakelyan, S, Bou-Orm, I, Holmer, H, Allen, LN, Witter, S, Ager, A, Diaconu, K

“…These policies have traditionally been treated as technical solutions, neglecting the critical influence of political economy dynamics. …”

‘An unimaginable challenge’: a cross-cultural qualitative study of ethics and decision-making around tracheostomy ventilation in patients with amyotrophic lateral sclerosis by Ozeki-Hayashi, R, Wilkinson, D

“…Previous studies have shown that doctors' values may affect decisionmaking. There have been no previous international qualitative comparisons of medical decision-making process for TIV or why practice varies. …”

Identifying falsified COVID-19 vaccines by analysing vaccine vial label and excipient profiles using MALDI-ToF mass spectrometry by Arman, BY, Clarke, R, Bharucha, T, Fernandez, LG, Walsby-Tickle, J, Deats, M, Mosca, S, Lin, Q, Banerjee, S, Chunekar, SR, Patil, KD, Gairola, S, Dunachie, S, Merchant, HA, Stokes, R, Kuwana, R, Maes, A, Charrier, J, Probert, F, Caillet, C, Matousek, P, McCullagh, J, Newton, PN, Zitzmann, N, Gangadharan, B

“…However, these developments are associated with the risk of a surge of substandard and falsified (SF) vaccines, as illustrated by the 184 incidents with SF and diverted COVID-19 vaccines which have been reported during the pandemic in 48 countries, with a paucity of methods for their detection in supply chains. …”

Associations of maternal night shift work during pregnancy with DNA methylation in offspring: a meta-analysis in the PACE consortium by Marques, IF, Domènech-Panicello, C, Geurtsen, ML, Hoang, TT, Richmond, R, Polinski, K, Sirignano, L, Page, CM, Binter, A, Everson, T, Burt, A, Deuschle, M, Gilles, M, Streit, F, Mumford, SL, Magnus, P, Reiss, IKM, Vermeulen, MJ, Witt, SH, Chaves, I, Yeung, E, London, SJ, Guxens, M, Felix, JF

“…Background: Night shift work during pregnancy has been associated with differential DNA methylation in placental tissue, but no studies have explored this association in cord blood. …”

Molecular mechanisms relevant to the maintenance of locomotor control by Guo, F

“…Preferential degeneration of the <em>Penk</em>+ MSNs has been observed at early stage of Huntington disease (HD). …”

A separation-of-powers model for a trustworthy and open cloud computing ecosystem by Ruan, A

“…Trusted Cloud models have been proposed, which establish a Root-of-Trust inside the cloud and vouch for the trustworthiness of the cloud services. …”

From the Andes to the coast: human mobility and diet in the Atacama desert during the late intermediate period (ad 900-1450) by Santana Sagredo, F

“…<p>The Late Intermediate Period in northern Chile has been strongly influenced by the mobility models of vertical archipelago and the gyratory mobility. …”

Prussian Blue analogue materials for magnetic and energy storage applications by Schart, M

“…Over the years since, many multifunctional properties have been discovered in its analogue materials. Members of the Prussian Blue analogue (PBA) family have shown promise for a wide variety of technological applications, ranging from energy and gas storage to catalysis and information storage. …”

Sudden gains in internet cognitive therapy for social anxiety disorder in routine clinical practice by Yim, SH, Clark, DM, Salkovskis, PM, Thew, GR

“…<p><strong>Background:</strong>&nbsp;Sudden gains are large symptom improvements between consecutive therapy sessions. They have been shown to occur in randomised controlled trials of internet-delivered psychological interventions, but little is known about their occurrence when such treatments are delivered in routine clinical practice.…”

Pathway and network analysis of more than 2500 whole cancer genomes by Reyna, MA, Haan, D, Paczkowska, M, Verbeke, LPC, Vazquez, M, Kahraman, A, Pulido-Tamayo, S, Barenboim, J, Wadi, L, Dhingra, P, Shrestha, R, Getz, G, Lawrence, MS, Pedersen, JS, Rubin, MA, Wheeler, DA, Brunak, S, Izarzugaza, JMG, Khurana, E, Marchal, K, von Mering, C, Sahinalp, SC, Valencia, A, PCAWG Drivers and Functional Interpretation Working Group, Reimand, J, Stuart, JM, Raphael, BJ, PCAWG Consortium

“…However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT promoter mutations, have been reported. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancer across 38 tumor types, we perform multi-faceted pathway and network analyses of non-coding mutations across 2583 whole cancer genomes from 27 tumor types compiled by the ICGC/TCGA PCAWG project that was motivated by the success of pathway and network analyses in prioritizing rare mutations in protein-coding genes. …”

The anatomy of Westlothiana lizziae and a novel phylogenetic analysis of early amniotes by Igielman, B

“…<em>Westlothiana</em> has been recovered in various phylogenetic positions, including as a sister taxon to amniotes, to lepospondyls, or to a lepospondyl-amniote clade. …”

Brain markers of cumulative stress response and allostatic load in the ageing Whitehall II cohort by Zsoldos, E

“…Since 1985, rich socio-demographic, health and life-style measures have been acquired every 2-5 years. Eight hundred participants were randomly selected from the remaining 6,308 participants of Phase 11 for magnetic resonance imaging (MRI) and further examination in Oxford (2012-14).…”