Development of the CHARIOT Research Register for the Prevention of Alzheimer’s Dementia and Other Late Onset Neurodegenerative Diseases by Larsen, Mark E., Curry, Lisa, Mastellos, Nikolaos, Robb, Catherine, Car, Josip, Middleton, Lefkos T.

“…Invitations were posted to individuals aged between 60 and 85 years, without a diagnosis of dementia. Upon consent, a minimum data set of demographic and contact details was extracted from the patient’s electronic health record. …”
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Infections diagnosed in children and young people screened for malaria in UK emergency departments: a retrospective multi-centre study by Bird, C, Hayward, GN, Turner, PJ, Wasala, D, Merrick, V, Lyttle, MD, Mullen, N, Fanshawe, TR

“…</p> <br> <p><strong>Methods:</strong> This is a retrospective, multi-centre, observational study nested in a diagnostic accuracy study for malaria rapid diagnostic tests. Any CYP less than 16 years presenting to a participating ED with a history of fever and travel to a malaria-endemic area between 1 January 2016 and 31 December 2017 and who had a malaria screen as a part of standard care were included. …”

Using feminist methodologies to explore female genital mutilation/cutting and child marriage in low- and middle-income contexts by Jones, N, Pincock, K, Alheiwidi, S

“…Eliminating harmful practices, which are rooted in gender inequality and have myriad life-course consequences for those who experience them, has become a global priority in recent years. However, dominant conceptualizations of the drivers and consequences of child marriage and FGM/C often fail to adequately engage with or reflect adolescent girls' own nuanced experiences and perceptions. …”

Mechanistic insights into the HPF1/PARP1 complex by Zobel, FFH

“…While PARP1 was originally described to modify target substrates on glutamate and aspartate sites, it has become apparent in recent years that the presence of another protein, histone PARylation factor 1 (HPF1), switches its preference to serine target sites. …”

HLA-DQB1*05 subtypes and not DRB1*10:01 mediates risk in anti-IgLON5 disease by Yogeshwar, SM, Muñiz-Castrillo, S, Sabater, L, Peris-Sempere, V, Mallajosyula, V, Luo, G, Yan, H, Yu, E, Zhang, J, Lin, L, Fagundes Bueno, F, Ji, X, Picard, G, Rogemond, V, Pinto, AL, Heidbreder, A, Höftberger, R, Graus, F, Dalmau, J, Santamaria, J, Iranzo, A, Schreiner, B, Giannoccaro, MP, Liguori, R, Shimohata, T, Kimura, A, Ono, Y, Binks, S, Mariotto, S, Dinoto, A, Bonello, M, Hartmann, CJ, Tambasco, N, Nigro, P, Prüss, H, McKeon, A, Davis, MM, Irani, SR, Honnorat, J, Gaig, C, Finke, C, Mignot, E

“…This association was further reflected in an increasingly later age of onset across each genotype group, with a delay of up to 11 years, while HLA-DQ-dosage dependent effects were also suggested by reduced risk in the presence of non-predisposing DQ1 alleles. …”

Experiences, perceptions and ethical considerations of the malaria infection study in Thailand by Naemiratch, B, Kulpijit, N, Ruangkajorn, S, Day, NPJ, Prachumsri, J, Cheah, PY

“…However, due to cross-border movements over the past 5 years, reported malaria cases in Thailand have risen. …”

Self-supervised machine learning to characterise step counts from wrist-worn accelerometers in the UK Biobank by Small, SR, Chan, S, Walmsley, R, von Fritsch, L, Acquah, A, Mertes, G, Feakins, BG, Creagh, A, Strange, A, Matthews, CE, Clifton, DA, Price, AJ, Khalid, S, Bennett, D, Doherty, A

“…Our data indicate an inverse dose-response association, where taking 6,430-8,277 daily steps was associated with 37% [25-48%] and 28% [20-35%] lower risk of fatal CVD and all-cause mortality up to seven years later, compared to those taking fewer steps each day.…”

Validating the ratio of insulin like growth factor binding protein 4 to sex hormone binding globulin as a prognostic predictor of preterm birth in Viet Nam: a case-cohort study by Hirst, JE, Boniface, JJ, Le, DP, Polpitiya, AD, Fox, AC, Vu, TTK, Dang, TT, Fleischer, TC, Bui, NTH, Hickok, DE, Kearney, PE, Thwaites, G, Kennedy, SH, Kestelyn, E, Le, TQ

“…Optimal performance (AUC 0.74) was seen within 19-20 weeks’ gestation, for BMI &gt;21 kg/m2 and age 20-35 years. <p><strong> Conclusion</strong></p> We have validated a novel serum biomarker for PTB risk stratification in a very different setting to the original study. …”

Multicenter double-blind study evaluating AI-driven detection of proximal deep vein thrombosis by Curry, N, Allen, E, Silsby, L, Goodacre, S, Deane, C, Deary, A, Foster, A, Griffiths, J, Sharma, R, Thomas, H, Mischewitz, S, Al-Noor, F

“…</p> <br> <p><strong>Methods:</strong> Eleven regional hospital DVT diagnostic clinics enrolled adult patients, 18 years of age or older, who were referred for investigation of symptoms suggestive of DVT, including a compression ultrasound. …”

Associations between snoring, body mass index and coronary artery diseases: observational and mendelian randomization study in Asia by Zhu, Y, Lan, Y, Lv, J, Sun, D, Pei, P, Yang, L, Millwood, IY, Walters, RG, Chen, Y, Du, H, Wang, J, Yang, X, Stevens, R, Chen, J, Chen, Z, Li, L, Yu, C

“…<p><strong>Results</strong></p> During a median follow-up of 12.32 years, 48,997 participants developed CAD. Snoring and habitual snoring were associated with incident CAD and myocardial infarction (MI), habitual snoring was also associated with stable angina pectoris (SAP). …”

May measurement month 2022: an analysis of blood pressure screening findings from Sierra Leone by Jalloh, MB, Williams, CEE, Jegede, OG, Malijan, GMB, Naveed, A, Kanu, A, Bah, AK, Jalloh, F, Jalloh, A, Faulkner, MMJ, Agboola, K, Baldeh, M, Russell, JBW, Oladapo, OO

“…Results: Among the participants (mean age 38.0 years, predominantly Black), the prevalence of hypertension was 25.7% (210 out of 818 participants). …”

Frailty, multimorbidity and polypharmacy: exploratory analyses of the effects of empagliflozin from the EMPA-KIDNEY trial by Mayne, KM, Sardell, R, Staplin, N, Judge, P, Zhu, D, Sammons, E, Wanner, C, Emberson, J, Preiss, D, Landray, M, Baigent, C, Haynes, R, Herrington, W

“…</p> <br> <p><strong>Methods:</strong> The EMPA-KIDNEY trial randomized 6609 patients with CKD (estimated glomerular filtration rate [eGFR] ≥20<45 mL/min/1.73m2 , or ≥45<90 mL/min/1.73m2 with urinary albumin-to-creatinine ratio ≥200 mg/g) to receive either empagliflozin 10 mg daily or matching placebo and followed for two years (median). Additional characteristics analysed in subgroups were multimorbidity, polypharmacy and health-related quality of life (HRQoL) at baseline. …”

The geomorphic work of the European mole (Talpa europaea): long-term monitoring of molehills using structure-from-motion photogrammetry by Baxter, T, Woor, S, Coombes, M, Viles, H

“…</em><em>europaea</em> over larger spatial scales (e.g. river catchments) and longer timescales (e.g. years‒decades) to determine its importance in relation to other bioturbators and within the wider sediment system.…”

The mediating role of health literacy between the presence of chronic disease and psychological distress among older persons in Xian City of China by Guo, Kun, Ouyang, Jing, Minhat, Halimatus Sakdiah

“…Methods: This study employs a quantitative research design using a cross-sectional survey of 300 older persons over 60 years living in the six urban districts of Xi’an city. …”
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Distributed consensus of second-order multi-agent systems by Yu, Zhong

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Mastering Voice Interfaces : Creating Great Voice Apps for Real Users / by Thymé-Gobbel, Ann, author 642940, Jankowski, Charles, author 642941

“…We start with the basics of voice interfaces, and how they are different from others, then dive into basic design principles that we're learned in many years building these apps in the industry. As we cover a design principle, we'll also demonstrate how to implement it with one of the established voice platforms (Google Home), and show how, though the tools are great, you don't have to go too far to have to do some custom work to get what you really want. …”

Behave The Biology of Humans at Our Best and Worst / by Sapolsky, Robert M., author 656050, Penguin Random House (Online service) 655978

“…And on and on, back to evolutionary factors millions of years old. The result is one of the most dazzling tours d'horizon of the science of human behavior ever attempted, a majestic synthesis that harvests cutting-edge research across a range of disciplines to provide a subtle and nuanced perspective on why we ultimately do the things we do...for good and for ill. …”
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Low-Cost Electronic Microfluidics for Multiplexed Point-of-Care Biomarker Detection by Kikkeri, Kruthika

“…As we have seen in recent years, point-of-care (PoC) systems are vital elements in healthcare, as they can aid in disease detection, monitoring, and treatment, and even inform public policy. …”
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From Shipyard to Sea: A Flexible System Design Approach to the Transition from Shipbuilding to Operations A Case Study Using the United States Coast Guard Offshore Patrol Cutter P... by Kime, Jeremy A.

“…At the same time, the Coast Guard is engaged in its largest shipbuilding effort since World War II, with seven acquisition programs scheduled to deliver 134 new ships over the next 15 years. In light of these factors the current approach, which places significant strain on crews, escalates costs, and delays operational use of the Coast Guard’s newest assets, warrants thorough examination. …”
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Tectonic influences on late Holocene relative sea levels from the central-eastern Adriatic coast of Croatia by Shaw, Timothy Adam, Plater, Andrew J., Kirby, Jason R., Roy, Keven, Holgate, Simon, Tutman, Pero, Cahill, Niamh, Horton, Benjamin Peter

“…Here, we compare reconstructions of RSL from the central-eastern Adriatic coast of Croatia with ICE-7G_NA (VM7) glacial-isostatic model RSL predictions to assess underlying driving mechanisms of RSL change during the past ∼ 2700 years. Local standardized published sea-level index points (n = 23) were combined with a new salt-marsh RSL reconstruction and tide-gauge measurements. …”
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