Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype by de Vos, Ivo J. H. M., Goggi, Julian L., Wilson, Gabrielle R., Stegmann, Alexander P. A., Amor, David J., Dunn, Norris Ray, Carney, Thomas James, Lockhart, Paul J., Coull, Barry J., van Steensel, Maurice A. M., Tao, Evelyn Yaqiong, Ong, Sheena Li Ming, Scerri, Thomas, Low, Chernis Guai Mun, Wong, Arnette Shi Wei, Grussu, Dominic, van Geel, Michel, Janssen, Renske, Bahlo, Melanie

“…Notably, the zebrafish model will be a valuable tool for developing novel therapeutic approaches to a devastating bone disorder.…”
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First clinical experience following the consensus guide for calibrating a proton stopping power ratio curve in a new proton centre by Koh, Calvin Wei Yang, Lew, Kah Seng, Wibawa, Andrew, Master, Zubin, Yeap, Ping Lin, Chua, Clifford Ghee Ann, Lee, James Cheow Lei, Tan, Hong Qi, Park, Sung Yong

“…Results: The results show a WET difference of less than 3.5% except for the result in the Bone region between Schneider's and ESTRO's methods. …”
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Development of image-based method for the quantitative assessment of cartilage damage from CT as a biomarker in osteoarthritis by Zheng, J-Q

“…In OA, cartilage damage and subchondral bone deformations are critical indicators. Therefore, this thesis introduces and validates two innovative frameworks for automated OA assessment, centering on the image analysis of cartilages and subchondral bones.…”

Improving detection of chromosomal abnormalities in multiple myeloma using fluorescence in situ hybridization by Naw, Wah Wah

“…D13S319/LAMP1 and IGH@/MAF, interphase FISH probes for del13q14 and t(14;16)(q32;q23) respectively, are used in this study to detect multiple myeloma cells in bone marrow aspirate of 20 patients. While CC could not detect del13q14 and t(14;16)(q32;q23) in any of the 20 patients, interphase FISH detected these chromosomal abnormalities in half (10/20) of the patients. …”
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Automated detection and segmentation of vertebral bodies in volumetric abdominal magnetic resonance images by Lin, Dehui.

“…Detection and segmentation of the column of vertebral bodies are intermediate steps required to identify the bone marrow which is considered as the wrongly labeled visceral adipose tissue in the assessment of abdominal obesity. …”
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Optimization of culture conditions in HS5 stroma suppported hematopoietic culture. by Goh, Carlye Qian Ling.

“…Stroma cells play an essential role in the bone marrow niche, the environment where hematopoietic cells and progenitors self-renew and differentiate into multiple lineage. …”
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Microfluidics based cell-cell interaction model by Bak Thavatchalam, Subhashree

“…In this study such a microfuidic chip has been developed whereby the bone marrow stromal cells have been cultured within the chip in a 3D microenvironment. …”
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Activated invariant NKT cells regulate osteoclast development and function by Hu, M, Bassett, JHD, Danks, L, Howell, PGT, Xu, K, Spanoudakis, E, Kotsianidis, I, Boyde, A, Williams, GR, Horwood, N, Roberts, I, Karadimitris, A

“…Because these same progenitors give rise to osteoclasts (OCs), which also mediate the egress of hematopoietic progenitors and orchestrate bone remodeling, we hypothesized that iNKT cells would extend their myeloid cell regulatory role to the development and function of OCs. …”

Structural insights into human brachyury DNA recognition and discovery of progressible binders for cancer therapy by Newman, JA, Gavard, AE, Imprachim, N, Aitkenhead, H, Sheppard, HE, te Poele, R, Clarke, PA, Hossain, MA, Temme, L, Oh, HJ, Wells, CI, Davis-Gilbert, ZW, Workman, P, Gileadi, O, Drewry, DH

“…Brachyury is a transcription factor that plays an essential role in tumour growth of the rare bone cancer chordoma and is implicated in other solid tumours. …”

CASTERS OF EVERVILLE / by Yap, Cherilyn, author 655829, Ikram Wazir, editor 655732

“…Wyn, a demon fairy with a heart of gold, is accused of a mysterious illness that spreads across the small town of Everville. Honey, his childhood friend, is determined to find a cure and put her life on the line in order to save her friend. …”

Mechanical characterization of an endoprosthesis. by Tan, Xue Yu.

“…Loss of mandibular bone as a result of trauma, inflammatory diseases and benign or malignant tumors demonstrated the need of mandibular reconstruction. …”
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Automatic knee segmentation from multi-contrast MR images by Zhang, Kunlei

“…The automatic segmentations of knee bones, cartilages and menisci are evaluated on a comprehensive multi-contrast MRI database. …”
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Clinical, genetic and omics-based biomarkers that might support the identification of the development of psoriatic arthritis in individuals with psoriasis – a narrative review of t... by Grohmann, T, Vivekanantham, A, Coates, L, Pennington, S, FitzGerald, O

“…Furthermore, there are considerable delays in diagnosis and treatment of PsA, which lead to joint and bone deformation and chronic pain. It is therefore important to develop more precise diagnostic and screening tools. …”

BMP signaling promotes zebrafish heart regeneration via alleviation of replication stress by Vasudevarao, MD, Posadas Pena, D, Ihle, M, Bongiovanni, C, Maity, P, Geissler, D, Mohammadi, HF, Rall-Scharpf, M, Niemann, J, Mommersteeg, MTM, Redaelli, S, Happ, K, Wu, C, Beisaw, A, Scharffetter-Kochanek, K, D’Uva, G, Malek Mohammadi, M, Wiesmüller, L, Geiger, H, Weidinger, G

“…Pharmacological inhibition of ATM and ATR kinases revealed that DNA damage response signaling is essential for zebrafish heart regeneration. Manipulation of Bone Morphogenetic Protein (BMP)-Smad signaling using transgenics and mutants showed that BMP signaling alleviates cardiomyocyte replication stress. …”

Tropism of subgroup J avian leukosis virus as detected by in situ hybridization by Arshad, S. S., Smith, L. M., Howes, K., Russell, P. H., Venugopal, K., Payne, L. N.

“…Viral gene expression could not be detected in the bone marrow or tumour tissues using this test. Higher levels of viral gene expression in the bursa of Fabricius infected with RAV-1, but not with HPRS-103, might help explain the inability of the latter virus to induce lymphoid leukosis.…”
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Effects of dehydrothermal treatment on collagen by Yeo, Sherrill Yan Ling.

“…Collagen is the most fundamental unit of the extra cellular matrix and is found in most mammal tissues such as the tendon, cartilage, bone and skin. Due to its excellent biocompatibility, collagen is often used as a matrix for cell infiltration in many tissue regenerative applications. …”
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Synthesis and application of titanium dioxide nanotube and composites by Liang, Kun

“…Two different applications were explored using TiO2 nanotube structures and its composites: bone morphogenetic protein-2 (BMP-2) delivery and photocatalytic for water purification. …”
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Ontogeny of intestinal intratumoural macrophages and their contribution in cancer regulation by Soncin, Irene

“…In contrast to their LP counterparts, the intratumoural F4/80(hi) macrophages are able to self-renew and lose the bone marrow dependency. Since their depletion via CSF1R blockade diminishes the tumour burden, our data underline the potential of these tumour-promoting intestinal macrophages as an attractive target for successful cancer immunotherapies.…”
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Elucidation of the EP defect in Diamond-Blackfan anemia by characterization and prospective isolation of human EPs by Iskander, D, Psaila, B, Gerrard, G, Chaidos, A, Foong, HE, Harrington, Y, Karnik, LC, Roberts, I, de la Fuente, J, Karadimitris, A

“…By combining flow cytometry, cell-sorting, and single-cell clonogenic assays, we identified Lin(-)CD34(+)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(-)CD36(-) bone marrow cells as EEP giving rise to BFU-E, and Lin(-)CD34(+/-)CD38(+)CD45RA(-)CD123(-)CD71(+)CD41a(-)CD105(+)CD36(+) cells as LEP giving rise to CFU-E, in a hierarchical fashion. …”

Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria by Gargiulo, L, Papaioannou, M, Sica, M, Talini, G, Chaidos, A, Richichi, B, Nikolaev, AV, Nativi, C, Layton, M, de la Fuente, J, Roberts, I, Luzzatto, L, Notaro, R, Karadimitris, A

“…The mechanism of bone marrow failure (BMF) in paroxysmal nocturnal hemoglobinuria (PNH) is not yet known. …”